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Gene: MICOS13 |
Gene summary for MICOS13 |
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Gene information | Species | Human | Gene symbol | MICOS13 | Gene ID | 125988 |
Gene name | mitochondrial contact site and cristae organizing system subunit 13 | |
Gene Alias | C19orf70 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006996 | UniProtAcc | A0A140TA86 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
125988 | MICOS13 | HTA11_546_2000001011 | Human | Colorectum | AD | 8.36e-09 | 3.47e-01 | -0.0842 |
125988 | MICOS13 | HTA11_7862_2000001011 | Human | Colorectum | AD | 3.08e-04 | 1.98e-01 | -0.0179 |
125988 | MICOS13 | HTA11_866_3004761011 | Human | Colorectum | AD | 4.40e-10 | 2.39e-01 | 0.096 |
125988 | MICOS13 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.49e-08 | 4.15e-01 | 0.0446 |
125988 | MICOS13 | HTA11_8622_2000001021 | Human | Colorectum | SER | 4.45e-03 | 2.05e-01 | 0.0528 |
125988 | MICOS13 | HTA11_7663_2000001011 | Human | Colorectum | SER | 6.81e-04 | 3.09e-01 | 0.0131 |
125988 | MICOS13 | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.46e-07 | 2.81e-01 | -0.0177 |
125988 | MICOS13 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.85e-04 | 3.00e-01 | 0.0171 |
125988 | MICOS13 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.67e-11 | 2.93e-01 | 0.0338 |
125988 | MICOS13 | HTA11_7696_3000711011 | Human | Colorectum | AD | 3.52e-13 | 2.89e-01 | 0.0674 |
125988 | MICOS13 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.11e-02 | 1.82e-01 | 0.0112 |
125988 | MICOS13 | HTA11_7469_2000001011 | Human | Colorectum | AD | 3.81e-02 | 2.90e-01 | -0.0124 |
125988 | MICOS13 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.37e-04 | 1.94e-01 | 0.0588 |
125988 | MICOS13 | LZE2D | Human | Esophagus | HGIN | 1.57e-04 | 5.36e-01 | 0.0642 |
125988 | MICOS13 | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 6.95e-01 | 0.082 |
125988 | MICOS13 | LZE3D | Human | Esophagus | HGIN | 8.88e-07 | 8.48e-01 | 0.0668 |
125988 | MICOS13 | LZE4T | Human | Esophagus | ESCC | 1.48e-34 | 8.43e-01 | 0.0811 |
125988 | MICOS13 | LZE5T | Human | Esophagus | ESCC | 3.88e-21 | 1.29e+00 | 0.0514 |
125988 | MICOS13 | LZE7T | Human | Esophagus | ESCC | 1.17e-28 | 1.25e+00 | 0.0667 |
125988 | MICOS13 | LZE8T | Human | Esophagus | ESCC | 2.99e-27 | 8.95e-01 | 0.067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00070067 | Cervix | CC | mitochondrial membrane organization | 28/2311 | 116/18723 | 3.28e-04 | 3.47e-03 | 28 |
GO:00070074 | Cervix | CC | inner mitochondrial membrane organization | 11/2311 | 38/18723 | 4.94e-03 | 2.95e-02 | 11 |
GO:0007006 | Colorectum | AD | mitochondrial membrane organization | 48/3918 | 116/18723 | 4.53e-07 | 1.72e-05 | 48 |
GO:0007007 | Colorectum | AD | inner mitochondrial membrane organization | 18/3918 | 38/18723 | 2.45e-04 | 3.09e-03 | 18 |
GO:00070061 | Colorectum | SER | mitochondrial membrane organization | 38/2897 | 116/18723 | 2.66e-06 | 1.10e-04 | 38 |
GO:00070071 | Colorectum | SER | inner mitochondrial membrane organization | 14/2897 | 38/18723 | 1.06e-03 | 1.23e-02 | 14 |
GO:000700618 | Esophagus | HGIN | mitochondrial membrane organization | 37/2587 | 116/18723 | 4.61e-07 | 2.07e-05 | 37 |
GO:00070076 | Esophagus | HGIN | inner mitochondrial membrane organization | 16/2587 | 38/18723 | 1.82e-05 | 4.93e-04 | 16 |
GO:000700619 | Esophagus | ESCC | mitochondrial membrane organization | 93/8552 | 116/18723 | 2.16e-14 | 1.11e-12 | 93 |
GO:000700713 | Esophagus | ESCC | inner mitochondrial membrane organization | 31/8552 | 38/18723 | 5.93e-06 | 6.10e-05 | 31 |
GO:00424072 | Esophagus | ESCC | cristae formation | 13/8552 | 16/18723 | 4.05e-03 | 1.62e-02 | 13 |
GO:00070069 | Prostate | BPH | mitochondrial membrane organization | 35/3107 | 116/18723 | 1.98e-04 | 1.63e-03 | 35 |
GO:000700616 | Prostate | Tumor | mitochondrial membrane organization | 35/3246 | 116/18723 | 4.65e-04 | 3.48e-03 | 35 |
GO:000700620 | Skin | AK | mitochondrial membrane organization | 25/1910 | 116/18723 | 2.31e-04 | 2.56e-03 | 25 |
GO:0007006110 | Skin | cSCC | mitochondrial membrane organization | 64/4864 | 116/18723 | 2.16e-11 | 1.08e-09 | 64 |
GO:00070077 | Skin | cSCC | inner mitochondrial membrane organization | 24/4864 | 38/18723 | 1.54e-06 | 2.62e-05 | 24 |
GO:00424073 | Skin | cSCC | cristae formation | 9/4864 | 16/18723 | 9.73e-03 | 4.31e-02 | 9 |
GO:00070064 | Stomach | GC | mitochondrial membrane organization | 18/1159 | 116/18723 | 2.71e-04 | 4.44e-03 | 18 |
GO:000700611 | Stomach | CAG with IM | mitochondrial membrane organization | 18/1050 | 116/18723 | 7.92e-05 | 1.86e-03 | 18 |
GO:000700621 | Stomach | CSG | mitochondrial membrane organization | 18/1034 | 116/18723 | 6.51e-05 | 1.61e-03 | 18 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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