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Gene: MICA |
Gene summary for MICA |
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Gene information | Species | Human | Gene symbol | MICA | Gene ID | 100507436 |
Gene name | MHC class I polypeptide-related sequence A | |
Gene Alias | MIC-A | |
Cytomap | 6p21.33 | |
Gene Type | protein-coding | GO ID | GO:0001775 | UniProtAcc | Q29983 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
100507436 | MICA | P22T-E | Human | Esophagus | ESCC | 3.12e-22 | 3.45e-01 | 0.1236 |
100507436 | MICA | P23T-E | Human | Esophagus | ESCC | 4.17e-22 | 5.47e-01 | 0.108 |
100507436 | MICA | P24T-E | Human | Esophagus | ESCC | 4.93e-10 | 3.01e-01 | 0.1287 |
100507436 | MICA | P26T-E | Human | Esophagus | ESCC | 2.49e-16 | 3.78e-01 | 0.1276 |
100507436 | MICA | P27T-E | Human | Esophagus | ESCC | 6.41e-14 | 2.97e-01 | 0.1055 |
100507436 | MICA | P28T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.72e-01 | 0.1149 |
100507436 | MICA | P30T-E | Human | Esophagus | ESCC | 1.73e-09 | 4.54e-01 | 0.137 |
100507436 | MICA | P31T-E | Human | Esophagus | ESCC | 1.35e-16 | 3.78e-01 | 0.1251 |
100507436 | MICA | P32T-E | Human | Esophagus | ESCC | 5.64e-19 | 4.48e-01 | 0.1666 |
100507436 | MICA | P36T-E | Human | Esophagus | ESCC | 3.62e-13 | 4.26e-01 | 0.1187 |
100507436 | MICA | P37T-E | Human | Esophagus | ESCC | 6.37e-17 | 4.52e-01 | 0.1371 |
100507436 | MICA | P39T-E | Human | Esophagus | ESCC | 4.70e-03 | 5.18e-02 | 0.0894 |
100507436 | MICA | P40T-E | Human | Esophagus | ESCC | 9.07e-05 | 2.37e-01 | 0.109 |
100507436 | MICA | P42T-E | Human | Esophagus | ESCC | 1.58e-10 | 2.95e-01 | 0.1175 |
100507436 | MICA | P44T-E | Human | Esophagus | ESCC | 3.58e-03 | 4.05e-02 | 0.1096 |
100507436 | MICA | P47T-E | Human | Esophagus | ESCC | 1.47e-11 | 2.33e-01 | 0.1067 |
100507436 | MICA | P48T-E | Human | Esophagus | ESCC | 3.18e-16 | 2.38e-01 | 0.0959 |
100507436 | MICA | P49T-E | Human | Esophagus | ESCC | 8.39e-08 | 7.73e-01 | 0.1768 |
100507436 | MICA | P52T-E | Human | Esophagus | ESCC | 5.35e-28 | 6.67e-01 | 0.1555 |
100507436 | MICA | P54T-E | Human | Esophagus | ESCC | 4.64e-17 | 3.60e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000701510 | Cervix | CC | actin filament organization | 109/2311 | 442/18723 | 4.92e-13 | 2.45e-10 | 109 |
GO:00081549 | Cervix | CC | actin polymerization or depolymerization | 51/2311 | 218/18723 | 4.05e-06 | 1.05e-04 | 51 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00329847 | Cervix | CC | protein-containing complex disassembly | 41/2311 | 224/18723 | 6.13e-03 | 3.48e-02 | 41 |
GO:00068873 | Cervix | CC | exocytosis | 59/2311 | 352/18723 | 8.74e-03 | 4.48e-02 | 59 |
GO:0007015 | Colorectum | AD | actin filament organization | 167/3918 | 442/18723 | 1.65e-16 | 7.94e-14 | 167 |
GO:1903829 | Colorectum | AD | positive regulation of cellular protein localization | 110/3918 | 276/18723 | 4.58e-13 | 8.44e-11 | 110 |
GO:0006839 | Colorectum | AD | mitochondrial transport | 102/3918 | 254/18723 | 1.87e-12 | 3.08e-10 | 102 |
GO:0008154 | Colorectum | AD | actin polymerization or depolymerization | 90/3918 | 218/18723 | 6.14e-12 | 8.23e-10 | 90 |
GO:0072594 | Colorectum | AD | establishment of protein localization to organelle | 148/3918 | 422/18723 | 7.95e-12 | 1.04e-09 | 148 |
GO:0030041 | Colorectum | AD | actin filament polymerization | 81/3918 | 191/18723 | 1.35e-11 | 1.69e-09 | 81 |
GO:0051258 | Colorectum | AD | protein polymerization | 112/3918 | 297/18723 | 1.85e-11 | 2.27e-09 | 112 |
GO:0016197 | Colorectum | AD | endosomal transport | 90/3918 | 230/18723 | 1.88e-10 | 1.73e-08 | 90 |
GO:0045216 | Colorectum | AD | cell-cell junction organization | 80/3918 | 200/18723 | 5.57e-10 | 4.58e-08 | 80 |
GO:0022411 | Colorectum | AD | cellular component disassembly | 147/3918 | 443/18723 | 8.53e-10 | 6.76e-08 | 147 |
GO:1904951 | Colorectum | AD | positive regulation of establishment of protein localization | 112/3918 | 319/18723 | 2.55e-09 | 1.80e-07 | 112 |
GO:0051222 | Colorectum | AD | positive regulation of protein transport | 106/3918 | 303/18723 | 8.45e-09 | 5.08e-07 | 106 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0098876 | Colorectum | AD | vesicle-mediated transport to the plasma membrane | 57/3918 | 136/18723 | 2.30e-08 | 1.27e-06 | 57 |
GO:0032984 | Colorectum | AD | protein-containing complex disassembly | 81/3918 | 224/18723 | 9.41e-08 | 4.65e-06 | 81 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05167211 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0516738 | Esophagus | ESCC | Kaposi sarcoma-associated herpesvirus infection | 136/4205 | 194/8465 | 4.28e-09 | 4.22e-08 | 2.16e-08 | 136 |
hsa0516721 | Liver | HCC | Kaposi sarcoma-associated herpesvirus infection | 111/4020 | 194/8465 | 3.78e-03 | 1.16e-02 | 6.45e-03 | 111 |
hsa0516731 | Liver | HCC | Kaposi sarcoma-associated herpesvirus infection | 111/4020 | 194/8465 | 3.78e-03 | 1.16e-02 | 6.45e-03 | 111 |
hsa0516729 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
hsa05167113 | Oral cavity | OSCC | Kaposi sarcoma-associated herpesvirus infection | 125/3704 | 194/8465 | 3.67e-09 | 3.84e-08 | 1.96e-08 | 125 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MICA | SNV | Missense_Mutation | rs746669979 | c.173G>A | p.Arg58His | p.R58H | protein_coding | tolerated(1) | benign(0.009) | TCGA-A2-A1FW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
MICA | SNV | Missense_Mutation | c.507G>C | p.Leu169Phe | p.L169F | protein_coding | tolerated(0.06) | possibly_damaging(0.624) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | ||
MICA | insertion | Frame_Shift_Ins | novel | c.517_518insGAGAAGT | p.Ala173GlyfsTer89 | p.A173Gfs*89 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |||
MICA | insertion | Frame_Shift_Ins | novel | c.518_519insACTGCTGGGTGGGGGCAGGCTTG | p.Met174LeufsTer9 | p.M174Lfs*9 | protein_coding | TCGA-AQ-A04J-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |||
MICA | SNV | Missense_Mutation | c.360N>C | p.Glu120Asp | p.E120D | protein_coding | tolerated(0.05) | possibly_damaging(0.835) | TCGA-DG-A2KM-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD | ||
MICA | SNV | Missense_Mutation | novel | c.73N>T | p.Pro25Ser | p.P25S | protein_coding | tolerated(0.55) | possibly_damaging(0.887) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
MICA | SNV | Missense_Mutation | novel | c.982C>A | p.Leu328Ile | p.L328I | protein_coding | tolerated_low_confidence(0.13) | benign(0.052) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
MICA | SNV | Missense_Mutation | novel | c.98N>T | p.Thr33Met | p.T33M | protein_coding | deleterious(0.04) | benign(0.11) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MICA | SNV | Missense_Mutation | novel | c.545N>A | p.Ala182Asp | p.A182D | protein_coding | tolerated(0.25) | possibly_damaging(0.887) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD | |
MICA | SNV | Missense_Mutation | novel | c.82C>T | p.Leu28Phe | p.L28F | protein_coding | deleterious(0.05) | probably_damaging(0.999) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
100507436 | MICA | EXTERNAL SIDE OF PLASMA MEMBRANE, CELL SURFACE | HSP70 | 17911639 |
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