![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: MFSD12 |
Gene summary for MFSD12 |
![]() |
Gene information | Species | Human | Gene symbol | MFSD12 | Gene ID | 126321 |
Gene name | major facilitator superfamily domain containing 12 | |
Gene Alias | C19orf28 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000101 | UniProtAcc | Q6NUT3 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
126321 | MFSD12 | P37T-E | Human | Esophagus | ESCC | 8.20e-30 | 7.20e-01 | 0.1371 |
126321 | MFSD12 | P38T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.78e-01 | 0.127 |
126321 | MFSD12 | P39T-E | Human | Esophagus | ESCC | 5.49e-05 | 1.04e-01 | 0.0894 |
126321 | MFSD12 | P40T-E | Human | Esophagus | ESCC | 7.66e-09 | 2.52e-01 | 0.109 |
126321 | MFSD12 | P42T-E | Human | Esophagus | ESCC | 2.02e-05 | 2.79e-01 | 0.1175 |
126321 | MFSD12 | P44T-E | Human | Esophagus | ESCC | 5.38e-04 | 1.34e-01 | 0.1096 |
126321 | MFSD12 | P47T-E | Human | Esophagus | ESCC | 1.83e-05 | 1.47e-01 | 0.1067 |
126321 | MFSD12 | P48T-E | Human | Esophagus | ESCC | 1.13e-03 | 7.90e-02 | 0.0959 |
126321 | MFSD12 | P52T-E | Human | Esophagus | ESCC | 4.56e-18 | 4.05e-01 | 0.1555 |
126321 | MFSD12 | P54T-E | Human | Esophagus | ESCC | 7.93e-12 | 2.49e-01 | 0.0975 |
126321 | MFSD12 | P61T-E | Human | Esophagus | ESCC | 2.93e-12 | 1.39e-01 | 0.099 |
126321 | MFSD12 | P62T-E | Human | Esophagus | ESCC | 3.18e-08 | 1.86e-01 | 0.1302 |
126321 | MFSD12 | P74T-E | Human | Esophagus | ESCC | 1.53e-10 | 1.44e-01 | 0.1479 |
126321 | MFSD12 | P75T-E | Human | Esophagus | ESCC | 3.78e-15 | 2.82e-01 | 0.1125 |
126321 | MFSD12 | P76T-E | Human | Esophagus | ESCC | 4.44e-09 | 1.62e-01 | 0.1207 |
126321 | MFSD12 | P80T-E | Human | Esophagus | ESCC | 1.33e-16 | 4.44e-01 | 0.155 |
126321 | MFSD12 | P82T-E | Human | Esophagus | ESCC | 5.47e-04 | 2.07e-01 | 0.1072 |
126321 | MFSD12 | P83T-E | Human | Esophagus | ESCC | 2.23e-15 | 4.34e-01 | 0.1738 |
126321 | MFSD12 | P89T-E | Human | Esophagus | ESCC | 7.42e-04 | 2.17e-01 | 0.1752 |
126321 | MFSD12 | P91T-E | Human | Esophagus | ESCC | 2.50e-13 | 7.22e-01 | 0.1828 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00461482 | Esophagus | ESCC | pigment biosynthetic process | 40/8552 | 62/18723 | 2.14e-03 | 9.54e-03 | 40 |
GO:00434731 | Esophagus | ESCC | pigmentation | 59/8552 | 98/18723 | 2.64e-03 | 1.12e-02 | 59 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:00424401 | Esophagus | ESCC | pigment metabolic process | 50/8552 | 84/18723 | 7.34e-03 | 2.64e-02 | 50 |
GO:19016172 | Liver | HCC | organic hydroxy compound biosynthetic process | 129/7958 | 237/18723 | 1.32e-04 | 1.08e-03 | 129 |
GO:0042440 | Liver | HCC | pigment metabolic process | 51/7958 | 84/18723 | 5.74e-04 | 3.65e-03 | 51 |
GO:0046148 | Liver | HCC | pigment biosynthetic process | 37/7958 | 62/18723 | 4.73e-03 | 2.02e-02 | 37 |
GO:0008643 | Liver | HCC | carbohydrate transport | 80/7958 | 152/18723 | 7.34e-03 | 2.92e-02 | 80 |
GO:19016173 | Oral cavity | OSCC | organic hydroxy compound biosynthetic process | 115/7305 | 237/18723 | 1.73e-03 | 8.18e-03 | 115 |
GO:00461481 | Oral cavity | OSCC | pigment biosynthetic process | 36/7305 | 62/18723 | 1.82e-03 | 8.57e-03 | 36 |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MFSD12 | SNV | Missense_Mutation | novel | c.983N>G | p.Ser328Cys | p.S328C | Q6NUT3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AC-A3W6-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
MFSD12 | SNV | Missense_Mutation | novel | c.443N>A | p.Ser148Tyr | p.S148Y | Q6NUT3 | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-C8-A8HP-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR |
MFSD12 | deletion | Frame_Shift_Del | novel | c.1358delN | p.Val453GlyfsTer31 | p.V453Gfs*31 | Q6NUT3 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
MFSD12 | SNV | Missense_Mutation | c.146N>G | p.Ser49Trp | p.S49W | Q6NUT3 | protein_coding | tolerated(0.18) | probably_damaging(0.959) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | |
MFSD12 | deletion | Frame_Shift_Del | c.766delC | p.Leu256CysfsTer30 | p.L256Cfs*30 | Q6NUT3 | protein_coding | TCGA-EA-A3HU-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |||
MFSD12 | SNV | Missense_Mutation | rs569176426 | c.1082N>T | p.Ala361Val | p.A361V | Q6NUT3 | protein_coding | tolerated(0.34) | benign(0.005) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MFSD12 | SNV | Missense_Mutation | novel | c.323N>C | p.Phe108Ser | p.F108S | Q6NUT3 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
MFSD12 | SNV | Missense_Mutation | c.1433N>G | p.Ala478Gly | p.A478G | Q6NUT3 | protein_coding | tolerated_low_confidence(0.3) | benign(0.018) | TCGA-CA-5796-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | oxaliplatin | CR | |
MFSD12 | SNV | Missense_Mutation | c.380N>T | p.Ala127Val | p.A127V | Q6NUT3 | protein_coding | tolerated(0.12) | benign(0.326) | TCGA-DM-A28F-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
MFSD12 | SNV | Missense_Mutation | rs372325734 | c.500C>T | p.Thr167Met | p.T167M | Q6NUT3 | protein_coding | deleterious(0) | probably_damaging(0.978) | TCGA-NH-A50T-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |