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Gene: METTL2A |
Gene summary for METTL2A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | METTL2A | Gene ID | 339175 |
| Gene name | methyltransferase 2A, methylcytidine | |
| Gene Alias | METTL2 | |
| Cytomap | 17q23.2 | |
| Gene Type | protein-coding | GO ID | GO:0001510 | UniProtAcc | B3KM33 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 339175 | METTL2A | P23T-E | Human | Esophagus | ESCC | 2.29e-39 | 8.74e-01 | 0.108 |
| 339175 | METTL2A | P24T-E | Human | Esophagus | ESCC | 1.95e-12 | 3.57e-01 | 0.1287 |
| 339175 | METTL2A | P26T-E | Human | Esophagus | ESCC | 2.60e-26 | 4.93e-01 | 0.1276 |
| 339175 | METTL2A | P27T-E | Human | Esophagus | ESCC | 2.85e-14 | 2.73e-01 | 0.1055 |
| 339175 | METTL2A | P28T-E | Human | Esophagus | ESCC | 3.38e-18 | 3.96e-01 | 0.1149 |
| 339175 | METTL2A | P30T-E | Human | Esophagus | ESCC | 4.64e-13 | 4.42e-01 | 0.137 |
| 339175 | METTL2A | P31T-E | Human | Esophagus | ESCC | 7.90e-15 | 3.45e-01 | 0.1251 |
| 339175 | METTL2A | P32T-E | Human | Esophagus | ESCC | 5.79e-30 | 6.63e-01 | 0.1666 |
| 339175 | METTL2A | P36T-E | Human | Esophagus | ESCC | 1.39e-20 | 5.99e-01 | 0.1187 |
| 339175 | METTL2A | P37T-E | Human | Esophagus | ESCC | 1.40e-13 | 2.71e-01 | 0.1371 |
| 339175 | METTL2A | P38T-E | Human | Esophagus | ESCC | 6.52e-06 | 1.65e-01 | 0.127 |
| 339175 | METTL2A | P39T-E | Human | Esophagus | ESCC | 7.53e-11 | 2.19e-01 | 0.0894 |
| 339175 | METTL2A | P40T-E | Human | Esophagus | ESCC | 9.43e-05 | 1.52e-01 | 0.109 |
| 339175 | METTL2A | P42T-E | Human | Esophagus | ESCC | 1.61e-15 | 3.88e-01 | 0.1175 |
| 339175 | METTL2A | P47T-E | Human | Esophagus | ESCC | 7.21e-09 | 1.25e-01 | 0.1067 |
| 339175 | METTL2A | P48T-E | Human | Esophagus | ESCC | 1.46e-04 | 1.48e-01 | 0.0959 |
| 339175 | METTL2A | P49T-E | Human | Esophagus | ESCC | 2.94e-18 | 1.05e+00 | 0.1768 |
| 339175 | METTL2A | P52T-E | Human | Esophagus | ESCC | 2.21e-16 | 4.47e-01 | 0.1555 |
| 339175 | METTL2A | P54T-E | Human | Esophagus | ESCC | 8.33e-13 | 3.07e-01 | 0.0975 |
| 339175 | METTL2A | P56T-E | Human | Esophagus | ESCC | 9.83e-05 | 4.90e-01 | 0.1613 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:003447015 | Esophagus | ESCC | ncRNA processing | 300/8552 | 395/18723 | 3.09e-35 | 3.26e-32 | 300 |
| GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
| GO:00434143 | Esophagus | ESCC | macromolecule methylation | 199/8552 | 316/18723 | 3.44e-10 | 9.57e-09 | 199 |
| GO:00080333 | Esophagus | ESCC | tRNA processing | 92/8552 | 127/18723 | 7.83e-10 | 1.93e-08 | 92 |
| GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
| GO:00322592 | Esophagus | ESCC | methylation | 222/8552 | 364/18723 | 2.26e-09 | 5.09e-08 | 222 |
| GO:00094512 | Esophagus | ESCC | RNA modification | 114/8552 | 167/18723 | 2.76e-09 | 6.04e-08 | 114 |
| GO:00015101 | Esophagus | ESCC | RNA methylation | 58/8552 | 83/18723 | 6.87e-06 | 6.94e-05 | 58 |
| GO:00064002 | Esophagus | ESCC | tRNA modification | 62/8552 | 90/18723 | 7.02e-06 | 7.04e-05 | 62 |
| GO:00304881 | Esophagus | ESCC | tRNA methylation | 30/8552 | 41/18723 | 3.27e-04 | 1.93e-03 | 30 |
| GO:00344702 | Liver | HCC | ncRNA processing | 293/7958 | 395/18723 | 4.26e-38 | 6.76e-35 | 293 |
| GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
| GO:0008033 | Liver | HCC | tRNA processing | 87/7958 | 127/18723 | 2.66e-09 | 7.23e-08 | 87 |
| GO:00434141 | Liver | HCC | macromolecule methylation | 183/7958 | 316/18723 | 2.00e-08 | 4.72e-07 | 183 |
| GO:0032259 | Liver | HCC | methylation | 206/7958 | 364/18723 | 3.35e-08 | 7.53e-07 | 206 |
| GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
| GO:0009451 | Liver | HCC | RNA modification | 101/7958 | 167/18723 | 2.02e-06 | 2.78e-05 | 101 |
| GO:0006400 | Liver | HCC | tRNA modification | 60/7958 | 90/18723 | 3.09e-06 | 4.09e-05 | 60 |
| GO:0001510 | Liver | HCC | RNA methylation | 53/7958 | 83/18723 | 6.96e-05 | 6.29e-04 | 53 |
| GO:0030488 | Liver | HCC | tRNA methylation | 29/7958 | 41/18723 | 2.38e-04 | 1.79e-03 | 29 |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| METTL2A | SNV | Missense_Mutation | c.730G>C | p.Glu244Gln | p.E244Q | Q96IZ6 | protein_coding | tolerated(0.7) | benign(0.015) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| METTL2A | SNV | Missense_Mutation | c.415N>C | p.Glu139Gln | p.E139Q | Q96IZ6 | protein_coding | tolerated(0.12) | probably_damaging(0.946) | TCGA-OL-A5RW-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | CR | |
| METTL2A | SNV | Missense_Mutation | c.575G>A | p.Gly192Glu | p.G192E | Q96IZ6 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| METTL2A | SNV | Missense_Mutation | c.16N>T | p.Pro6Ser | p.P6S | Q96IZ6 | protein_coding | tolerated_low_confidence(0.18) | benign(0) | TCGA-AA-3858-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| METTL2A | SNV | Missense_Mutation | novel | c.331N>A | p.His111Asn | p.H111N | Q96IZ6 | protein_coding | tolerated(0.4) | benign(0) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
| METTL2A | SNV | Missense_Mutation | rs753699667 | c.434N>T | p.Ser145Leu | p.S145L | Q96IZ6 | protein_coding | tolerated(0.28) | benign(0.018) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
| METTL2A | SNV | Missense_Mutation | c.496N>G | p.Ser166Gly | p.S166G | Q96IZ6 | protein_coding | tolerated(0.37) | benign(0.01) | TCGA-G4-6628-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| METTL2A | SNV | Missense_Mutation | c.496N>C | p.Ser166Arg | p.S166R | Q96IZ6 | protein_coding | tolerated(0.37) | benign(0.068) | TCGA-AG-3728-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | folinic | CR | |
| METTL2A | SNV | Missense_Mutation | rs757983960 | c.295N>A | p.Glu99Lys | p.E99K | Q96IZ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| METTL2A | SNV | Missense_Mutation | novel | c.1058N>G | p.Asn353Ser | p.N353S | Q96IZ6 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-A5-A0VP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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