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Gene: MANBAL |
Gene summary for MANBAL |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | MANBAL | Gene ID | 63905 |
| Gene name | mannosidase beta like | |
| Gene Alias | MANBAL | |
| Cytomap | 20q11.23 | |
| Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9NQG1 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 63905 | MANBAL | P20T-E | Human | Esophagus | ESCC | 1.16e-55 | 1.24e+00 | 0.1124 |
| 63905 | MANBAL | P21T-E | Human | Esophagus | ESCC | 5.48e-68 | 1.97e+00 | 0.1617 |
| 63905 | MANBAL | P22T-E | Human | Esophagus | ESCC | 7.30e-45 | 9.53e-01 | 0.1236 |
| 63905 | MANBAL | P23T-E | Human | Esophagus | ESCC | 1.42e-37 | 1.07e+00 | 0.108 |
| 63905 | MANBAL | P24T-E | Human | Esophagus | ESCC | 9.15e-22 | 6.47e-01 | 0.1287 |
| 63905 | MANBAL | P26T-E | Human | Esophagus | ESCC | 1.02e-76 | 1.50e+00 | 0.1276 |
| 63905 | MANBAL | P27T-E | Human | Esophagus | ESCC | 1.68e-24 | 5.98e-01 | 0.1055 |
| 63905 | MANBAL | P28T-E | Human | Esophagus | ESCC | 9.74e-18 | 3.56e-01 | 0.1149 |
| 63905 | MANBAL | P30T-E | Human | Esophagus | ESCC | 4.09e-37 | 1.29e+00 | 0.137 |
| 63905 | MANBAL | P31T-E | Human | Esophagus | ESCC | 1.28e-64 | 1.15e+00 | 0.1251 |
| 63905 | MANBAL | P32T-E | Human | Esophagus | ESCC | 1.70e-46 | 9.62e-01 | 0.1666 |
| 63905 | MANBAL | P36T-E | Human | Esophagus | ESCC | 4.06e-13 | 6.69e-01 | 0.1187 |
| 63905 | MANBAL | P37T-E | Human | Esophagus | ESCC | 5.20e-29 | 6.26e-01 | 0.1371 |
| 63905 | MANBAL | P38T-E | Human | Esophagus | ESCC | 7.62e-10 | 6.12e-01 | 0.127 |
| 63905 | MANBAL | P39T-E | Human | Esophagus | ESCC | 4.50e-20 | 4.09e-01 | 0.0894 |
| 63905 | MANBAL | P40T-E | Human | Esophagus | ESCC | 1.88e-19 | 4.03e-01 | 0.109 |
| 63905 | MANBAL | P42T-E | Human | Esophagus | ESCC | 4.83e-31 | 8.20e-01 | 0.1175 |
| 63905 | MANBAL | P44T-E | Human | Esophagus | ESCC | 4.06e-13 | 4.85e-01 | 0.1096 |
| 63905 | MANBAL | P47T-E | Human | Esophagus | ESCC | 8.02e-28 | 5.53e-01 | 0.1067 |
| 63905 | MANBAL | P48T-E | Human | Esophagus | ESCC | 1.35e-16 | 4.11e-01 | 0.0959 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| MANBAL | SNV | Missense_Mutation | rs139446010 | c.67N>T | p.Arg23Trp | p.R23W | Q9NQG1 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR |
| MANBAL | SNV | Missense_Mutation | c.74N>A | p.Gly25Glu | p.G25E | Q9NQG1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| MANBAL | SNV | Missense_Mutation | rs139446010 | c.67N>T | p.Arg23Trp | p.R23W | Q9NQG1 | protein_coding | tolerated(0.07) | probably_damaging(0.998) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
| MANBAL | SNV | Missense_Mutation | rs755003934 | c.29N>T | p.Pro10Leu | p.P10L | Q9NQG1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-AJ-A3OK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | CR |
| MANBAL | SNV | Missense_Mutation | novel | c.201N>T | p.Lys67Asn | p.K67N | Q9NQG1 | protein_coding | deleterious(0.02) | possibly_damaging(0.587) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
| MANBAL | SNV | Missense_Mutation | rs777773368 | c.124G>A | p.Val42Ile | p.V42I | Q9NQG1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-AX-A1CE-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unspecific | Paclitaxel | SD |
| MANBAL | SNV | Missense_Mutation | rs777773368 | c.124G>A | p.Val42Ile | p.V42I | Q9NQG1 | protein_coding | tolerated(1) | benign(0.001) | TCGA-E6-A1LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| MANBAL | SNV | Missense_Mutation | rs747541266 | c.145N>A | p.Glu49Lys | p.E49K | Q9NQG1 | protein_coding | tolerated(0.32) | benign(0.265) | TCGA-49-6743-01 | Lung | lung adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | cisplatin | SD |
| MANBAL | SNV | Missense_Mutation | rs755003934 | c.29C>T | p.Pro10Leu | p.P10L | Q9NQG1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.999) | TCGA-18-3407-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
| MANBAL | SNV | Missense_Mutation | c.230N>T | p.Pro77Leu | p.P77L | Q9NQG1 | protein_coding | tolerated(0.22) | benign(0.144) | TCGA-63-5131-01 | Lung | lung squamous cell carcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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