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Gene: MALL |
Gene summary for MALL |
Gene summary. |
Gene information | Species | Human | Gene symbol | MALL | Gene ID | 7851 |
Gene name | mal, T cell differentiation protein like | |
Gene Alias | BENE | |
Cytomap | 2q13 | |
Gene Type | protein-coding | GO ID | GO:0007272 | UniProtAcc | Q13021 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
7851 | MALL | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.87e-03 | 4.53e-01 | -0.1207 |
7851 | MALL | HTA11_696_2000001011 | Human | Colorectum | AD | 3.49e-14 | 9.81e-01 | -0.1464 |
7851 | MALL | HTA11_2992_2000001011 | Human | Colorectum | SER | 5.92e-05 | 8.59e-01 | -0.1706 |
7851 | MALL | HTA11_5212_2000001011 | Human | Colorectum | AD | 1.16e-15 | 1.51e+00 | -0.2061 |
7851 | MALL | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.52e-04 | -1.99e-01 | 0.0674 |
7851 | MALL | A002-C-010 | Human | Colorectum | FAP | 7.35e-04 | -1.72e-01 | 0.242 |
7851 | MALL | A002-C-203 | Human | Colorectum | FAP | 2.07e-07 | -2.00e-01 | 0.2786 |
7851 | MALL | A002-C-205 | Human | Colorectum | FAP | 6.81e-05 | -2.11e-01 | -0.1236 |
7851 | MALL | A015-C-106 | Human | Colorectum | FAP | 4.68e-02 | -1.64e-01 | -0.0511 |
7851 | MALL | A015-C-104 | Human | Colorectum | FAP | 1.14e-03 | -1.76e-01 | -0.1899 |
7851 | MALL | A001-C-203 | Human | Colorectum | FAP | 1.04e-02 | -1.54e-01 | -0.0481 |
7851 | MALL | A002-C-116 | Human | Colorectum | FAP | 1.07e-05 | -1.96e-01 | -0.0452 |
7851 | MALL | F034 | Human | Colorectum | FAP | 2.19e-04 | -1.96e-01 | -0.0665 |
7851 | MALL | LZE2T | Human | Esophagus | ESCC | 4.73e-03 | 6.08e-01 | 0.082 |
7851 | MALL | LZE4T | Human | Esophagus | ESCC | 1.70e-03 | 1.83e-01 | 0.0811 |
7851 | MALL | LZE5T | Human | Esophagus | ESCC | 1.54e-04 | 6.08e-01 | 0.0514 |
7851 | MALL | LZE8T | Human | Esophagus | ESCC | 2.41e-13 | 5.42e-01 | 0.067 |
7851 | MALL | LZE20T | Human | Esophagus | ESCC | 3.99e-15 | 8.00e-01 | 0.0662 |
7851 | MALL | LZE22D1 | Human | Esophagus | HGIN | 2.88e-06 | 3.60e-01 | 0.0595 |
7851 | MALL | LZE22T | Human | Esophagus | ESCC | 1.28e-07 | 8.17e-01 | 0.068 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00425524 | Esophagus | ESCC | myelination | 85/8552 | 134/18723 | 2.51e-05 | 2.13e-04 | 85 |
GO:00072724 | Esophagus | ESCC | ensheathment of neurons | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00083664 | Esophagus | ESCC | axon ensheathment | 86/8552 | 136/18723 | 2.68e-05 | 2.24e-04 | 86 |
GO:00550882 | Liver | HCC | lipid homeostasis | 103/7958 | 167/18723 | 4.27e-07 | 7.18e-06 | 103 |
GO:005509221 | Liver | HCC | sterol homeostasis | 59/7958 | 97/18723 | 2.06e-04 | 1.58e-03 | 59 |
GO:004263221 | Liver | HCC | cholesterol homeostasis | 58/7958 | 96/18723 | 2.99e-04 | 2.13e-03 | 58 |
GO:00072721 | Liver | HCC | ensheathment of neurons | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00083661 | Liver | HCC | axon ensheathment | 72/7958 | 136/18723 | 8.87e-03 | 3.44e-02 | 72 |
GO:00425521 | Liver | HCC | myelination | 71/7958 | 134/18723 | 9.08e-03 | 3.49e-02 | 71 |
GO:00072723 | Oral cavity | OSCC | ensheathment of neurons | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00083663 | Oral cavity | OSCC | axon ensheathment | 72/7305 | 136/18723 | 6.59e-04 | 3.70e-03 | 72 |
GO:00425523 | Oral cavity | OSCC | myelination | 71/7305 | 134/18723 | 6.93e-04 | 3.86e-03 | 71 |
GO:00425522 | Prostate | Tumor | myelination | 34/3246 | 134/18723 | 1.19e-02 | 4.85e-02 | 34 |
GO:004255221 | Skin | cSCC | myelination | 51/4864 | 134/18723 | 1.37e-03 | 8.70e-03 | 51 |
GO:000727221 | Skin | cSCC | ensheathment of neurons | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:000836621 | Skin | cSCC | axon ensheathment | 51/4864 | 136/18723 | 1.99e-03 | 1.19e-02 | 51 |
GO:0042632 | Stomach | GC | cholesterol homeostasis | 17/1159 | 96/18723 | 7.61e-05 | 1.64e-03 | 17 |
GO:0055092 | Stomach | GC | sterol homeostasis | 17/1159 | 97/18723 | 8.70e-05 | 1.81e-03 | 17 |
GO:0055088 | Stomach | GC | lipid homeostasis | 24/1159 | 167/18723 | 9.86e-05 | 2.00e-03 | 24 |
GO:00426321 | Stomach | WIM | cholesterol homeostasis | 8/426 | 96/18723 | 1.56e-03 | 2.06e-02 | 8 |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
MALL | insertion | Frame_Shift_Ins | novel | c.21_22insATCTGCAGAGCTGTGCGTATGCA | p.Ala8IlefsTer36 | p.A8Ifs*36 | Q13021 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MALL | insertion | Frame_Shift_Ins | novel | c.19_20insTC | p.Pro7LeufsTer30 | p.P7Lfs*30 | Q13021 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
MALL | SNV | Missense_Mutation | rs764376036 | c.197C>T | p.Ser66Leu | p.S66L | Q13021 | protein_coding | tolerated(0.14) | benign(0.028) | TCGA-AM-5821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
MALL | SNV | Missense_Mutation | rs763390418 | c.154T>C | p.Tyr52His | p.Y52H | Q13021 | protein_coding | tolerated(0.54) | benign(0.155) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
MALL | SNV | Missense_Mutation | c.202N>A | p.Leu68Ile | p.L68I | Q13021 | protein_coding | tolerated(0.22) | possibly_damaging(0.48) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
MALL | SNV | Missense_Mutation | c.117N>A | p.Phe39Leu | p.F39L | Q13021 | protein_coding | tolerated(0.16) | benign(0.025) | TCGA-BS-A0UF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
MALL | SNV | Missense_Mutation | c.245A>G | p.Tyr82Cys | p.Y82C | Q13021 | protein_coding | deleterious(0) | probably_damaging(0.923) | TCGA-BS-A0UV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MALL | SNV | Missense_Mutation | novel | c.268G>A | p.Val90Ile | p.V90I | Q13021 | protein_coding | tolerated(0.27) | benign(0.019) | TCGA-EO-A22R-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
MALL | SNV | Missense_Mutation | c.117C>A | p.Phe39Leu | p.F39L | Q13021 | protein_coding | tolerated(0.16) | benign(0.025) | TCGA-EO-A3B0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
MALL | SNV | Missense_Mutation | c.146N>G | p.His49Arg | p.H49R | Q13021 | protein_coding | tolerated(0.77) | benign(0) | TCGA-21-1076-01 | Lung | lung squamous cell carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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