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Gene: LYRM2 |
Gene summary for LYRM2 |
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Gene information | Species | Human | Gene symbol | LYRM2 | Gene ID | 57226 |
Gene name | LYR motif containing 2 | |
Gene Alias | DJ122O8.2 | |
Cytomap | 6q15 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | Q9NU23 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
57226 | LYRM2 | P12T-E | Human | Esophagus | ESCC | 3.44e-30 | 5.82e-01 | 0.1122 |
57226 | LYRM2 | P15T-E | Human | Esophagus | ESCC | 6.00e-24 | 5.41e-01 | 0.1149 |
57226 | LYRM2 | P16T-E | Human | Esophagus | ESCC | 1.04e-46 | 8.61e-01 | 0.1153 |
57226 | LYRM2 | P17T-E | Human | Esophagus | ESCC | 3.74e-12 | 5.13e-01 | 0.1278 |
57226 | LYRM2 | P19T-E | Human | Esophagus | ESCC | 1.54e-12 | 6.47e-01 | 0.1662 |
57226 | LYRM2 | P20T-E | Human | Esophagus | ESCC | 4.15e-23 | 3.63e-01 | 0.1124 |
57226 | LYRM2 | P21T-E | Human | Esophagus | ESCC | 5.40e-51 | 1.17e+00 | 0.1617 |
57226 | LYRM2 | P22T-E | Human | Esophagus | ESCC | 1.58e-23 | 3.87e-01 | 0.1236 |
57226 | LYRM2 | P23T-E | Human | Esophagus | ESCC | 1.63e-25 | 6.23e-01 | 0.108 |
57226 | LYRM2 | P24T-E | Human | Esophagus | ESCC | 1.32e-23 | 4.91e-01 | 0.1287 |
57226 | LYRM2 | P26T-E | Human | Esophagus | ESCC | 1.03e-27 | 5.36e-01 | 0.1276 |
57226 | LYRM2 | P27T-E | Human | Esophagus | ESCC | 2.33e-30 | 6.63e-01 | 0.1055 |
57226 | LYRM2 | P28T-E | Human | Esophagus | ESCC | 3.75e-48 | 8.90e-01 | 0.1149 |
57226 | LYRM2 | P30T-E | Human | Esophagus | ESCC | 4.49e-31 | 1.10e+00 | 0.137 |
57226 | LYRM2 | P31T-E | Human | Esophagus | ESCC | 9.12e-48 | 8.62e-01 | 0.1251 |
57226 | LYRM2 | P32T-E | Human | Esophagus | ESCC | 6.52e-26 | 4.13e-01 | 0.1666 |
57226 | LYRM2 | P36T-E | Human | Esophagus | ESCC | 6.20e-16 | 4.83e-01 | 0.1187 |
57226 | LYRM2 | P37T-E | Human | Esophagus | ESCC | 2.70e-28 | 5.67e-01 | 0.1371 |
57226 | LYRM2 | P38T-E | Human | Esophagus | ESCC | 8.02e-11 | 3.28e-01 | 0.127 |
57226 | LYRM2 | P39T-E | Human | Esophagus | ESCC | 2.85e-08 | 1.66e-01 | 0.0894 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LYRM2 | insertion | Frame_Shift_Ins | novel | c.244_245insA | p.Thr82AsnfsTer14 | p.T82Nfs*14 | Q9NU23 | protein_coding | TCGA-AA-3695-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
LYRM2 | SNV | Missense_Mutation | novel | c.212A>G | p.Gln71Arg | p.Q71R | Q9NU23 | protein_coding | tolerated(0.29) | probably_damaging(0.982) | TCGA-B5-A1MX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Hormone Therapy | megace | SD |
LYRM2 | SNV | Missense_Mutation | rs534210657 | c.169N>G | p.Lys57Glu | p.K57E | Q9NU23 | protein_coding | deleterious(0.03) | probably_damaging(0.994) | TCGA-95-7039-01 | Lung | lung adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
LYRM2 | SNV | Missense_Mutation | novel | c.186G>T | p.Glu62Asp | p.E62D | Q9NU23 | protein_coding | deleterious(0.01) | possibly_damaging(0.748) | TCGA-37-3789-01 | Lung | lung squamous cell carcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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