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Gene: LTB4R |
Gene summary for LTB4R |
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Gene information | Species | Human | Gene symbol | LTB4R | Gene ID | 1241 |
Gene name | leukotriene B4 receptor | |
Gene Alias | BLT1 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q15722 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
1241 | LTB4R | P47T-E | Human | Esophagus | ESCC | 8.24e-07 | 1.33e-01 | 0.1067 |
1241 | LTB4R | P48T-E | Human | Esophagus | ESCC | 2.66e-13 | 2.29e-01 | 0.0959 |
1241 | LTB4R | P52T-E | Human | Esophagus | ESCC | 2.15e-18 | 3.97e-01 | 0.1555 |
1241 | LTB4R | P54T-E | Human | Esophagus | ESCC | 4.73e-07 | 1.48e-01 | 0.0975 |
1241 | LTB4R | P57T-E | Human | Esophagus | ESCC | 5.70e-06 | 4.15e-02 | 0.0926 |
1241 | LTB4R | P61T-E | Human | Esophagus | ESCC | 5.52e-11 | 1.82e-01 | 0.099 |
1241 | LTB4R | P62T-E | Human | Esophagus | ESCC | 3.81e-15 | 1.59e-01 | 0.1302 |
1241 | LTB4R | P65T-E | Human | Esophagus | ESCC | 1.24e-04 | 1.03e-01 | 0.0978 |
1241 | LTB4R | P74T-E | Human | Esophagus | ESCC | 6.73e-11 | 3.22e-01 | 0.1479 |
1241 | LTB4R | P80T-E | Human | Esophagus | ESCC | 9.79e-07 | 3.28e-01 | 0.155 |
1241 | LTB4R | P83T-E | Human | Esophagus | ESCC | 1.07e-16 | 4.04e-01 | 0.1738 |
1241 | LTB4R | P89T-E | Human | Esophagus | ESCC | 4.29e-20 | 1.27e+00 | 0.1752 |
1241 | LTB4R | P91T-E | Human | Esophagus | ESCC | 1.19e-17 | 1.89e+00 | 0.1828 |
1241 | LTB4R | P107T-E | Human | Esophagus | ESCC | 7.19e-41 | 1.03e+00 | 0.171 |
1241 | LTB4R | P127T-E | Human | Esophagus | ESCC | 3.20e-02 | 4.06e-02 | 0.0826 |
1241 | LTB4R | P130T-E | Human | Esophagus | ESCC | 1.08e-04 | 7.66e-02 | 0.1676 |
1241 | LTB4R | C04 | Human | Oral cavity | OSCC | 3.30e-26 | 1.09e+00 | 0.2633 |
1241 | LTB4R | C21 | Human | Oral cavity | OSCC | 1.27e-14 | 6.49e-01 | 0.2678 |
1241 | LTB4R | C30 | Human | Oral cavity | OSCC | 8.91e-43 | 1.76e+00 | 0.3055 |
1241 | LTB4R | C43 | Human | Oral cavity | OSCC | 2.11e-52 | 9.59e-01 | 0.1704 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000166720 | Esophagus | ESCC | ameboidal-type cell migration | 250/8552 | 475/18723 | 1.22e-03 | 5.97e-03 | 250 |
GO:001063120 | Esophagus | ESCC | epithelial cell migration | 187/8552 | 357/18723 | 6.05e-03 | 2.23e-02 | 187 |
GO:009013220 | Esophagus | ESCC | epithelium migration | 188/8552 | 360/18723 | 6.96e-03 | 2.54e-02 | 188 |
GO:009013020 | Esophagus | ESCC | tissue migration | 190/8552 | 365/18723 | 7.91e-03 | 2.82e-02 | 190 |
GO:000166719 | Oral cavity | OSCC | ameboidal-type cell migration | 228/7305 | 475/18723 | 3.46e-05 | 3.10e-04 | 228 |
GO:001063118 | Oral cavity | OSCC | epithelial cell migration | 174/7305 | 357/18723 | 1.04e-04 | 7.70e-04 | 174 |
GO:009013218 | Oral cavity | OSCC | epithelium migration | 175/7305 | 360/18723 | 1.18e-04 | 8.54e-04 | 175 |
GO:009013018 | Oral cavity | OSCC | tissue migration | 176/7305 | 365/18723 | 1.92e-04 | 1.29e-03 | 176 |
GO:00030129 | Skin | AK | muscle system process | 64/1910 | 452/18723 | 4.32e-03 | 2.52e-02 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LTB4R | SNV | Missense_Mutation | novel | c.326N>A | p.Thr109Lys | p.T109K | Q15722 | protein_coding | deleterious(0.02) | possibly_damaging(0.758) | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LTB4R | SNV | Missense_Mutation | novel | c.401N>T | p.Ala134Val | p.A134V | Q15722 | protein_coding | tolerated(1) | benign(0.015) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LTB4R | SNV | Missense_Mutation | novel | c.602A>T | p.Tyr201Phe | p.Y201F | Q15722 | protein_coding | deleterious(0) | probably_damaging(0.986) | TCGA-VS-A950-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
LTB4R | SNV | Missense_Mutation | c.217T>C | p.Phe73Leu | p.F73L | Q15722 | protein_coding | tolerated(0.24) | benign(0.018) | TCGA-VS-A9UV-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | PD | |
LTB4R | insertion | In_Frame_Ins | novel | c.325_326insGTG | p.Thr109delinsSerAla | p.T109delinsSA | Q15722 | protein_coding | TCGA-EA-A411-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | ||
LTB4R | SNV | Missense_Mutation | novel | c.97N>G | p.Leu33Val | p.L33V | Q15722 | protein_coding | tolerated(0.06) | benign(0.018) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
LTB4R | SNV | Missense_Mutation | novel | c.263N>T | p.Ala88Val | p.A88V | Q15722 | protein_coding | tolerated(0.53) | benign(0.011) | TCGA-AA-3930-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | capecitabine | PD |
LTB4R | SNV | Missense_Mutation | c.568T>G | p.Phe190Val | p.F190V | Q15722 | protein_coding | deleterious(0) | probably_damaging(0.985) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LTB4R | SNV | Missense_Mutation | novel | c.221N>C | p.Phe74Ser | p.F74S | Q15722 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LTB4R | SNV | Missense_Mutation | novel | c.362G>A | p.Arg121His | p.R121H | Q15722 | protein_coding | tolerated(0.11) | possibly_damaging(0.88) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | CHEMBL1742420 | AMELUBANT | |
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651386 | ||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 178100421 | ||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | Biomed 101 | |||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | Amelubant | AMELUBANT | ||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | CP-195543 | CP-195543 | ||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 178102777 | SC-41390 | |
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 178102776 | CP-195543 | |
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 178100392 | ||
1241 | LTB4R | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | LTB 019 |
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