![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: LRRC28 |
Gene summary for LRRC28 |
![]() |
Gene information | Species | Human | Gene symbol | LRRC28 | Gene ID | 123355 |
Gene name | leucine rich repeat containing 28 | |
Gene Alias | LRRC28 | |
Cytomap | 15q26.3 | |
Gene Type | protein-coding | GO ID | NA | UniProtAcc | A0A024RC88 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
123355 | LRRC28 | P21T-E | Human | Esophagus | ESCC | 1.50e-13 | 3.08e-01 | 0.1617 |
123355 | LRRC28 | P22T-E | Human | Esophagus | ESCC | 2.47e-16 | 3.21e-01 | 0.1236 |
123355 | LRRC28 | P23T-E | Human | Esophagus | ESCC | 6.94e-26 | 5.71e-01 | 0.108 |
123355 | LRRC28 | P24T-E | Human | Esophagus | ESCC | 3.08e-05 | 1.44e-01 | 0.1287 |
123355 | LRRC28 | P26T-E | Human | Esophagus | ESCC | 6.89e-28 | 4.72e-01 | 0.1276 |
123355 | LRRC28 | P27T-E | Human | Esophagus | ESCC | 6.35e-10 | 2.33e-01 | 0.1055 |
123355 | LRRC28 | P28T-E | Human | Esophagus | ESCC | 2.33e-08 | 2.30e-01 | 0.1149 |
123355 | LRRC28 | P30T-E | Human | Esophagus | ESCC | 1.45e-13 | 4.61e-01 | 0.137 |
123355 | LRRC28 | P31T-E | Human | Esophagus | ESCC | 2.73e-21 | 1.84e-01 | 0.1251 |
123355 | LRRC28 | P32T-E | Human | Esophagus | ESCC | 2.32e-16 | 2.94e-01 | 0.1666 |
123355 | LRRC28 | P36T-E | Human | Esophagus | ESCC | 1.96e-15 | 2.67e-01 | 0.1187 |
123355 | LRRC28 | P37T-E | Human | Esophagus | ESCC | 9.50e-13 | 2.45e-01 | 0.1371 |
123355 | LRRC28 | P38T-E | Human | Esophagus | ESCC | 3.93e-09 | 3.92e-01 | 0.127 |
123355 | LRRC28 | P39T-E | Human | Esophagus | ESCC | 7.08e-11 | 2.33e-01 | 0.0894 |
123355 | LRRC28 | P40T-E | Human | Esophagus | ESCC | 2.19e-03 | 1.88e-01 | 0.109 |
123355 | LRRC28 | P42T-E | Human | Esophagus | ESCC | 4.79e-08 | 2.76e-01 | 0.1175 |
123355 | LRRC28 | P44T-E | Human | Esophagus | ESCC | 4.67e-10 | 3.44e-01 | 0.1096 |
123355 | LRRC28 | P47T-E | Human | Esophagus | ESCC | 6.97e-11 | 1.64e-01 | 0.1067 |
123355 | LRRC28 | P48T-E | Human | Esophagus | ESCC | 1.15e-10 | 1.84e-01 | 0.0959 |
123355 | LRRC28 | P49T-E | Human | Esophagus | ESCC | 8.50e-07 | 5.79e-01 | 0.1768 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LRRC28 | SNV | Missense_Mutation | c.587N>G | p.Pro196Arg | p.P196R | Q86X40 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-A8-A07R-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Ancillary | zoledronic | SD | |
LRRC28 | insertion | Nonsense_Mutation | novel | c.1080_1081insTCCTGAAAAGTTTTTAGGTAACCACCC | p.Leu360_Gln361insSerTerLysValPheArgTerProPro | p.L360_Q361insS*KVFR*PP | Q86X40 | protein_coding | TCGA-AO-A03R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
LRRC28 | SNV | Missense_Mutation | novel | c.890N>T | p.Pro297Leu | p.P297L | Q86X40 | protein_coding | deleterious(0.01) | possibly_damaging(0.521) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
LRRC28 | SNV | Missense_Mutation | c.797N>C | p.Glu266Ala | p.E266A | Q86X40 | protein_coding | tolerated(0.33) | benign(0) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LRRC28 | SNV | Missense_Mutation | rs750430368 | c.242N>T | p.Pro81Leu | p.P81L | Q86X40 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-A6-6141-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | 5-fu | SD |
LRRC28 | SNV | Missense_Mutation | c.248C>T | p.Ala83Val | p.A83V | Q86X40 | protein_coding | deleterious(0.02) | probably_damaging(0.983) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC28 | SNV | Missense_Mutation | c.638A>G | p.Asn213Ser | p.N213S | Q86X40 | protein_coding | deleterious(0.04) | benign(0.062) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
LRRC28 | SNV | Missense_Mutation | rs375152645 | c.497N>A | p.Arg166Gln | p.R166Q | Q86X40 | protein_coding | tolerated(0.06) | benign(0.005) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC28 | SNV | Missense_Mutation | rs199769485 | c.340N>T | p.Arg114Cys | p.R114C | Q86X40 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LRRC28 | SNV | Missense_Mutation | rs753306548 | c.502N>T | p.Arg168Cys | p.R168C | Q86X40 | protein_coding | tolerated(0.15) | benign(0.438) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 5 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |