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Gene: LGALS9 |
Gene summary for LGALS9 |
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Gene information | Species | Human | Gene symbol | LGALS9 | Gene ID | 3965 |
Gene name | galectin 9 | |
Gene Alias | HUAT | |
Cytomap | 17q11.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | O00182 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3965 | LGALS9 | HTA11_8622_2000001021 | Human | Colorectum | SER | 9.88e-04 | 5.39e-01 | 0.0528 |
3965 | LGALS9 | HTA11_10623_2000001011 | Human | Colorectum | AD | 4.33e-11 | 1.01e+00 | -0.0177 |
3965 | LGALS9 | HTA11_10711_2000001011 | Human | Colorectum | AD | 1.07e-14 | 7.05e-01 | 0.0338 |
3965 | LGALS9 | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.39e-25 | 1.00e+00 | 0.0674 |
3965 | LGALS9 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.80e-04 | 2.81e-01 | 0.0112 |
3965 | LGALS9 | HTA11_7469_2000001011 | Human | Colorectum | AD | 2.98e-13 | 1.36e+00 | -0.0124 |
3965 | LGALS9 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.22e-03 | 3.80e-01 | 0.294 |
3965 | LGALS9 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 2.82e-07 | 6.93e-01 | 0.2585 |
3965 | LGALS9 | A015-C-203 | Human | Colorectum | FAP | 8.03e-03 | 1.47e-01 | -0.1294 |
3965 | LGALS9 | A015-C-104 | Human | Colorectum | FAP | 4.51e-03 | 1.10e-01 | -0.1899 |
3965 | LGALS9 | A002-C-016 | Human | Colorectum | FAP | 6.40e-04 | -6.00e-02 | 0.0521 |
3965 | LGALS9 | A002-C-116 | Human | Colorectum | FAP | 4.15e-03 | -9.58e-02 | -0.0452 |
3965 | LGALS9 | F034 | Human | Colorectum | FAP | 3.27e-02 | -7.41e-02 | -0.0665 |
3965 | LGALS9 | F072B | Human | Colorectum | FAP | 8.58e-03 | -1.49e-01 | 0.257 |
3965 | LGALS9 | LZE7T | Human | Esophagus | ESCC | 2.62e-05 | 1.70e-01 | 0.0667 |
3965 | LGALS9 | LZE8T | Human | Esophagus | ESCC | 2.75e-17 | 6.51e-01 | 0.067 |
3965 | LGALS9 | LZE20T | Human | Esophagus | ESCC | 1.79e-02 | 1.51e-01 | 0.0662 |
3965 | LGALS9 | LZE22T | Human | Esophagus | ESCC | 9.67e-07 | 4.36e-01 | 0.068 |
3965 | LGALS9 | LZE24T | Human | Esophagus | ESCC | 4.21e-18 | 7.63e-01 | 0.0596 |
3965 | LGALS9 | LZE21T | Human | Esophagus | ESCC | 3.40e-09 | 8.21e-01 | 0.0655 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0016032 | Colorectum | AD | viral process | 168/3918 | 415/18723 | 4.67e-20 | 3.66e-17 | 168 |
GO:0019058 | Colorectum | AD | viral life cycle | 119/3918 | 317/18723 | 6.18e-12 | 8.23e-10 | 119 |
GO:0045862 | Colorectum | AD | positive regulation of proteolysis | 129/3918 | 372/18723 | 4.04e-10 | 3.46e-08 | 129 |
GO:0051656 | Colorectum | AD | establishment of organelle localization | 131/3918 | 390/18723 | 3.00e-09 | 2.06e-07 | 131 |
GO:0044403 | Colorectum | AD | biological process involved in symbiotic interaction | 99/3918 | 290/18723 | 1.02e-07 | 4.93e-06 | 99 |
GO:0051701 | Colorectum | AD | biological process involved in interaction with host | 73/3918 | 203/18723 | 5.08e-07 | 1.88e-05 | 73 |
GO:0048524 | Colorectum | AD | positive regulation of viral process | 31/3918 | 65/18723 | 1.33e-06 | 4.23e-05 | 31 |
GO:0052126 | Colorectum | AD | movement in host environment | 63/3918 | 175/18723 | 2.85e-06 | 8.11e-05 | 63 |
GO:0043281 | Colorectum | AD | regulation of cysteine-type endopeptidase activity involved in apoptotic process | 72/3918 | 209/18723 | 3.70e-06 | 1.03e-04 | 72 |
GO:2000116 | Colorectum | AD | regulation of cysteine-type endopeptidase activity | 79/3918 | 235/18723 | 3.74e-06 | 1.03e-04 | 79 |
GO:0052547 | Colorectum | AD | regulation of peptidase activity | 137/3918 | 461/18723 | 4.12e-06 | 1.12e-04 | 137 |
GO:0050792 | Colorectum | AD | regulation of viral process | 59/3918 | 164/18723 | 5.95e-06 | 1.52e-04 | 59 |
GO:0010952 | Colorectum | AD | positive regulation of peptidase activity | 68/3918 | 197/18723 | 6.30e-06 | 1.59e-04 | 68 |
GO:0048872 | Colorectum | AD | homeostasis of number of cells | 87/3918 | 272/18723 | 1.16e-05 | 2.61e-04 | 87 |
GO:0046718 | Colorectum | AD | viral entry into host cell | 51/3918 | 144/18723 | 3.99e-05 | 7.16e-04 | 51 |
GO:0052548 | Colorectum | AD | regulation of endopeptidase activity | 124/3918 | 432/18723 | 6.58e-05 | 1.07e-03 | 124 |
GO:1903900 | Colorectum | AD | regulation of viral life cycle | 51/3918 | 148/18723 | 9.01e-05 | 1.38e-03 | 51 |
GO:0010950 | Colorectum | AD | positive regulation of endopeptidase activity | 59/3918 | 179/18723 | 1.11e-04 | 1.65e-03 | 59 |
GO:0044409 | Colorectum | AD | entry into host | 51/3918 | 151/18723 | 1.60e-04 | 2.21e-03 | 51 |
GO:0043123 | Colorectum | AD | positive regulation of I-kappaB kinase/NF-kappaB signaling | 60/3918 | 186/18723 | 1.91e-04 | 2.56e-03 | 60 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | ADJ |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | ADJ |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | DCIS |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | DCIS |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | DCIS |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | Healthy |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | Healthy |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | Healthy |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Breast | IDC |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Breast | IDC |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Breast | IDC |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | ADJ |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | ADJ |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | ADJ |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | CC |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | CC |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | CC |
LGALS9 | PTPRC | LGALS9_CD45 | GALECTIN | Cervix | Precancer |
LGALS9 | HAVCR2 | LGALS9_HAVCR2 | GALECTIN | Cervix | Precancer |
LGALS9 | CD44 | LGALS9_CD44 | GALECTIN | Cervix | Precancer |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LGALS9 | SNV | Missense_Mutation | novel | c.520C>A | p.Pro174Thr | p.P174T | O00182 | protein_coding | deleterious(0.02) | benign(0.122) | TCGA-AN-A0G0-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | novel | c.70N>A | p.Gly24Ser | p.G24S | O00182 | protein_coding | tolerated(0.09) | possibly_damaging(0.763) | TCGA-C8-A27A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR |
LGALS9 | SNV | Missense_Mutation | novel | c.671N>T | p.Pro224Leu | p.P224L | O00182 | protein_coding | tolerated(0.17) | benign(0.001) | TCGA-EA-A410-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | c.25N>T | p.Pro9Ser | p.P9S | O00182 | protein_coding | tolerated(0.08) | benign(0.035) | TCGA-IR-A3LA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
LGALS9 | SNV | Missense_Mutation | novel | c.595N>G | p.Thr199Ala | p.T199A | O00182 | protein_coding | tolerated(0.19) | benign(0.003) | TCGA-A6-2686-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | rs147965169 | c.812N>A | p.Arg271His | p.R271H | O00182 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | novel | c.217G>A | p.Val73Met | p.V73M | O00182 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AA-3678-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | folinic | CR |
LGALS9 | SNV | Missense_Mutation | c.827C>T | p.Ala276Val | p.A276V | O00182 | protein_coding | tolerated(0.26) | benign(0.161) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LGALS9 | SNV | Missense_Mutation | rs147965169 | c.812N>A | p.Arg271His | p.R271H | O00182 | protein_coding | deleterious(0.02) | possibly_damaging(0.78) | TCGA-D5-6530-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
LGALS9 | SNV | Missense_Mutation | rs753232858 | c.274C>A | p.Pro92Thr | p.P92T | O00182 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AG-A02X-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3965 | LGALS9 | DRUGGABLE GENOME, TRANSPORTER | LACTOSE, ANHYDROUS | LACTOSE, ANHYDROUS | 21524586 |
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