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Gene: LENG9 |
Gene summary for LENG9 |
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Gene information | Species | Human | Gene symbol | LENG9 | Gene ID | 94059 |
Gene name | leukocyte receptor cluster member 9 | |
Gene Alias | LENG9 | |
Cytomap | 19q13.42 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WVD1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
94059 | LENG9 | P47T-E | Human | Esophagus | ESCC | 3.26e-06 | 1.20e-01 | 0.1067 |
94059 | LENG9 | P48T-E | Human | Esophagus | ESCC | 1.16e-07 | 1.46e-01 | 0.0959 |
94059 | LENG9 | P49T-E | Human | Esophagus | ESCC | 2.40e-02 | 2.03e-01 | 0.1768 |
94059 | LENG9 | P52T-E | Human | Esophagus | ESCC | 2.06e-09 | 1.51e-01 | 0.1555 |
94059 | LENG9 | P54T-E | Human | Esophagus | ESCC | 1.00e-11 | 2.85e-01 | 0.0975 |
94059 | LENG9 | P57T-E | Human | Esophagus | ESCC | 3.39e-10 | 1.90e-01 | 0.0926 |
94059 | LENG9 | P62T-E | Human | Esophagus | ESCC | 3.84e-14 | 2.86e-01 | 0.1302 |
94059 | LENG9 | P75T-E | Human | Esophagus | ESCC | 4.13e-19 | 3.45e-01 | 0.1125 |
94059 | LENG9 | P76T-E | Human | Esophagus | ESCC | 1.37e-08 | 1.57e-01 | 0.1207 |
94059 | LENG9 | P80T-E | Human | Esophagus | ESCC | 4.07e-22 | 6.59e-01 | 0.155 |
94059 | LENG9 | P82T-E | Human | Esophagus | ESCC | 2.50e-04 | 4.39e-01 | 0.1072 |
94059 | LENG9 | P83T-E | Human | Esophagus | ESCC | 9.80e-18 | 4.68e-01 | 0.1738 |
94059 | LENG9 | P84T-E | Human | Esophagus | ESCC | 2.54e-03 | 1.85e-01 | 0.0933 |
94059 | LENG9 | P107T-E | Human | Esophagus | ESCC | 4.67e-08 | 2.20e-01 | 0.171 |
94059 | LENG9 | P126T-E | Human | Esophagus | ESCC | 5.32e-03 | 4.66e-01 | 0.1125 |
94059 | LENG9 | P127T-E | Human | Esophagus | ESCC | 3.32e-06 | 1.64e-01 | 0.0826 |
94059 | LENG9 | P128T-E | Human | Esophagus | ESCC | 3.73e-11 | 4.55e-01 | 0.1241 |
94059 | LENG9 | P130T-E | Human | Esophagus | ESCC | 3.49e-14 | 3.14e-01 | 0.1676 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
LENG9 | SNV | Missense_Mutation | novel | c.419C>G | p.Ser140Trp | p.S140W | protein_coding | deleterious(0) | probably_damaging(0.969) | TCGA-BI-A0VS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.1363N>G | p.Gln455Glu | p.Q455E | protein_coding | tolerated(0.99) | benign(0.001) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
LENG9 | SNV | Missense_Mutation | novel | c.757N>T | p.Gly253Trp | p.G253W | protein_coding | deleterious(0.02) | benign(0.315) | TCGA-AA-3872-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | rs759547042 | c.1381N>T | p.Arg461Cys | p.R461C | protein_coding | tolerated(0.07) | probably_damaging(0.947) | TCGA-AZ-4313-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.993N>A | p.Phe331Leu | p.F331L | protein_coding | deleterious(0.01) | benign(0.214) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | insertion | Frame_Shift_Ins | rs757537115 | c.1401_1402insG | p.Pro468AlafsTer7 | p.P468Afs*7 | protein_coding | TCGA-CM-4746-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
LENG9 | SNV | Missense_Mutation | rs755113750 | c.985G>A | p.Ala329Thr | p.A329T | protein_coding | tolerated(0.13) | probably_damaging(0.996) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.1432N>A | p.Glu478Lys | p.E478K | protein_coding | tolerated_low_confidence(0.61) | benign(0.001) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.970N>A | p.Val324Met | p.V324M | protein_coding | tolerated(0.14) | benign(0.017) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
LENG9 | SNV | Missense_Mutation | novel | c.843G>T | p.Glu281Asp | p.E281D | protein_coding | tolerated(0.57) | benign(0) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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