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Gene: KRT81 |
Gene summary for KRT81 |
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Gene information | Species | Human | Gene symbol | KRT81 | Gene ID | 3887 |
Gene name | keratin 81 | |
Gene Alias | HB1 | |
Cytomap | 12q13.13 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q14533 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3887 | KRT81 | DCIS2 | Human | Breast | DCIS | 8.46e-12 | 5.95e-01 | 0.0085 |
3887 | KRT81 | P76T-E | Human | Esophagus | ESCC | 6.50e-66 | 4.05e+00 | 0.1207 |
3887 | KRT81 | P79T-E | Human | Esophagus | ESCC | 2.06e-08 | 1.65e+00 | 0.1154 |
3887 | KRT81 | P128T-E | Human | Esophagus | ESCC | 2.45e-04 | 1.07e+00 | 0.1241 |
3887 | KRT81 | P130T-E | Human | Esophagus | ESCC | 1.67e-53 | 3.22e+00 | 0.1676 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KRT81 | insertion | Nonsense_Mutation | novel | c.1016_1017insTCAGTGATGCCCGCT | p.Ala339_Lys340insGlnTerCysProLeu | p.A339_K340insQ*CPL | Q14533 | protein_coding | TCGA-BH-A0B9-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | SD | ||
KRT81 | SNV | Missense_Mutation | c.1370N>A | p.Cys457Tyr | p.C457Y | Q14533 | protein_coding | tolerated(0.14) | possibly_damaging(0.836) | TCGA-EK-A2R8-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KRT81 | SNV | Missense_Mutation | rs753782485 | c.28N>T | p.Arg10Cys | p.R10C | Q14533 | protein_coding | deleterious(0) | possibly_damaging(0.587) | TCGA-MA-AA42-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD |
KRT81 | SNV | Missense_Mutation | rs139838048 | c.1337N>A | p.Arg446Gln | p.R446Q | Q14533 | protein_coding | tolerated(0.37) | benign(0.019) | TCGA-ZX-AA5X-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
KRT81 | SNV | Missense_Mutation | novel | c.718N>G | p.Arg240Gly | p.R240G | Q14533 | protein_coding | deleterious(0.01) | benign(0.05) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
KRT81 | SNV | Missense_Mutation | novel | c.1295N>A | p.Arg432Gln | p.R432Q | Q14533 | protein_coding | tolerated(0.35) | benign(0.038) | TCGA-A6-2683-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | irinotecan | PD |
KRT81 | SNV | Missense_Mutation | rs145562431 | c.721N>T | p.Arg241Trp | p.R241W | Q14533 | protein_coding | deleterious(0.01) | possibly_damaging(0.846) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KRT81 | SNV | Missense_Mutation | rs767515484 | c.1181N>G | p.Asn394Ser | p.N394S | Q14533 | protein_coding | deleterious(0.04) | possibly_damaging(0.588) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
KRT81 | SNV | Missense_Mutation | c.715C>A | p.Leu239Met | p.L239M | Q14533 | protein_coding | deleterious(0.01) | possibly_damaging(0.633) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KRT81 | SNV | Missense_Mutation | c.1063N>A | p.Gln355Lys | p.Q355K | Q14533 | protein_coding | deleterious(0.01) | possibly_damaging(0.816) | TCGA-F5-6813-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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