![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KLK11 |
Gene summary for KLK11 |
![]() |
Gene information | Species | Human | Gene symbol | KLK11 | Gene ID | 11012 |
Gene name | kallikrein related peptidase 11 | |
Gene Alias | PRSS20 | |
Cytomap | 19q13.41 | |
Gene Type | protein-coding | GO ID | GO:0006508 | UniProtAcc | A0A1R3UDR5 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11012 | KLK11 | P17T-E | Human | Esophagus | ESCC | 5.62e-04 | 4.95e-01 | 0.1278 |
11012 | KLK11 | P20T-E | Human | Esophagus | ESCC | 1.74e-30 | 1.42e+00 | 0.1124 |
11012 | KLK11 | P21T-E | Human | Esophagus | ESCC | 2.07e-04 | 2.60e-01 | 0.1617 |
11012 | KLK11 | P22T-E | Human | Esophagus | ESCC | 1.12e-22 | 5.75e-01 | 0.1236 |
11012 | KLK11 | P26T-E | Human | Esophagus | ESCC | 6.38e-05 | 1.99e-01 | 0.1276 |
11012 | KLK11 | P27T-E | Human | Esophagus | ESCC | 1.82e-24 | 9.13e-01 | 0.1055 |
11012 | KLK11 | P28T-E | Human | Esophagus | ESCC | 6.22e-98 | 2.26e+00 | 0.1149 |
11012 | KLK11 | P30T-E | Human | Esophagus | ESCC | 4.12e-25 | 1.28e+00 | 0.137 |
11012 | KLK11 | P31T-E | Human | Esophagus | ESCC | 7.53e-18 | 6.80e-01 | 0.1251 |
11012 | KLK11 | P37T-E | Human | Esophagus | ESCC | 1.23e-02 | 1.86e-01 | 0.1371 |
11012 | KLK11 | P42T-E | Human | Esophagus | ESCC | 6.92e-20 | 6.97e-01 | 0.1175 |
11012 | KLK11 | P47T-E | Human | Esophagus | ESCC | 6.11e-16 | 5.35e-01 | 0.1067 |
11012 | KLK11 | P48T-E | Human | Esophagus | ESCC | 3.35e-25 | 7.31e-01 | 0.0959 |
11012 | KLK11 | P49T-E | Human | Esophagus | ESCC | 2.37e-17 | 1.27e+00 | 0.1768 |
11012 | KLK11 | P52T-E | Human | Esophagus | ESCC | 2.62e-16 | 4.46e-01 | 0.1555 |
11012 | KLK11 | P54T-E | Human | Esophagus | ESCC | 4.89e-06 | 6.18e-01 | 0.0975 |
11012 | KLK11 | P57T-E | Human | Esophagus | ESCC | 6.62e-04 | 2.96e-01 | 0.0926 |
11012 | KLK11 | P61T-E | Human | Esophagus | ESCC | 4.24e-19 | 5.53e-01 | 0.099 |
11012 | KLK11 | P62T-E | Human | Esophagus | ESCC | 5.53e-52 | 1.15e+00 | 0.1302 |
11012 | KLK11 | P65T-E | Human | Esophagus | ESCC | 3.74e-07 | 4.17e-01 | 0.0978 |
Page: 1 2 3 4 5 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
Page: 1 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLK11 | SNV | Missense_Mutation | c.187N>T | p.His63Tyr | p.H63Y | Q9UBX7 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KLK11 | SNV | Missense_Mutation | rs759212241 | c.80N>T | p.Ser27Phe | p.S27F | Q9UBX7 | protein_coding | deleterious(0.01) | benign(0.092) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD |
KLK11 | SNV | Missense_Mutation | novel | c.604N>C | p.Glu202Gln | p.E202Q | Q9UBX7 | protein_coding | tolerated(0.21) | benign(0.222) | TCGA-BH-A0B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLK11 | insertion | Frame_Shift_Ins | novel | c.742_743insCCGCGCCCGCCCGGCTTTCATTTATTAAT | p.Ile248ThrfsTer42 | p.I248Tfs*42 | Q9UBX7 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KLK11 | SNV | Missense_Mutation | rs759848513 | c.770N>T | p.Ala257Val | p.A257V | Q9UBX7 | protein_coding | deleterious(0.02) | possibly_damaging(0.878) | TCGA-AA-A01R-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | PD |
KLK11 | SNV | Missense_Mutation | c.199T>C | p.Trp67Arg | p.W67R | Q9UBX7 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
KLK11 | SNV | Missense_Mutation | rs200477811 | c.293C>T | p.Pro98Leu | p.P98L | Q9UBX7 | protein_coding | tolerated(0.08) | benign(0.025) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KLK11 | deletion | Frame_Shift_Del | c.710delG | p.Gly237AlafsTer43 | p.G237Afs*43 | Q9UBX7 | protein_coding | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
KLK11 | SNV | Missense_Mutation | rs539901509 | c.22C>T | p.Arg8Trp | p.R8W | Q9UBX7 | protein_coding | deleterious_low_confidence(0.01) | benign(0.18) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KLK11 | SNV | Missense_Mutation | rs201147335 | c.242C>T | p.Ala81Val | p.A81V | Q9UBX7 | protein_coding | deleterious(0) | probably_damaging(0.93) | TCGA-AP-A056-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 4 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |