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Gene: KLHL36 |
Gene summary for KLHL36 |
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Gene information | Species | Human | Gene symbol | KLHL36 | Gene ID | 79786 |
Gene name | kelch like family member 36 | |
Gene Alias | C16orf44 | |
Cytomap | 16q24.1 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q8N4N3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79786 | KLHL36 | P32T-E | Human | Esophagus | ESCC | 4.00e-08 | 1.26e-01 | 0.1666 |
79786 | KLHL36 | P36T-E | Human | Esophagus | ESCC | 5.88e-06 | 2.55e-01 | 0.1187 |
79786 | KLHL36 | P37T-E | Human | Esophagus | ESCC | 4.63e-11 | 1.30e-01 | 0.1371 |
79786 | KLHL36 | P39T-E | Human | Esophagus | ESCC | 1.04e-03 | 8.10e-02 | 0.0894 |
79786 | KLHL36 | P40T-E | Human | Esophagus | ESCC | 9.54e-09 | 1.78e-01 | 0.109 |
79786 | KLHL36 | P42T-E | Human | Esophagus | ESCC | 7.44e-05 | 9.52e-02 | 0.1175 |
79786 | KLHL36 | P44T-E | Human | Esophagus | ESCC | 6.40e-12 | 1.91e-01 | 0.1096 |
79786 | KLHL36 | P47T-E | Human | Esophagus | ESCC | 1.36e-09 | 2.02e-01 | 0.1067 |
79786 | KLHL36 | P48T-E | Human | Esophagus | ESCC | 5.57e-14 | 1.97e-01 | 0.0959 |
79786 | KLHL36 | P49T-E | Human | Esophagus | ESCC | 1.88e-07 | 8.46e-01 | 0.1768 |
79786 | KLHL36 | P52T-E | Human | Esophagus | ESCC | 1.86e-10 | 2.17e-01 | 0.1555 |
79786 | KLHL36 | P54T-E | Human | Esophagus | ESCC | 4.89e-10 | 2.13e-01 | 0.0975 |
79786 | KLHL36 | P56T-E | Human | Esophagus | ESCC | 1.61e-02 | 3.81e-01 | 0.1613 |
79786 | KLHL36 | P57T-E | Human | Esophagus | ESCC | 5.60e-14 | 2.37e-01 | 0.0926 |
79786 | KLHL36 | P61T-E | Human | Esophagus | ESCC | 2.41e-18 | 2.73e-01 | 0.099 |
79786 | KLHL36 | P62T-E | Human | Esophagus | ESCC | 8.21e-23 | 5.08e-01 | 0.1302 |
79786 | KLHL36 | P65T-E | Human | Esophagus | ESCC | 4.84e-15 | 3.04e-01 | 0.0978 |
79786 | KLHL36 | P74T-E | Human | Esophagus | ESCC | 5.67e-09 | 2.57e-01 | 0.1479 |
79786 | KLHL36 | P75T-E | Human | Esophagus | ESCC | 3.06e-15 | 2.68e-01 | 0.1125 |
79786 | KLHL36 | P76T-E | Human | Esophagus | ESCC | 1.52e-11 | 1.81e-01 | 0.1207 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KLHL36 | insertion | Frame_Shift_Ins | novel | c.1191_1192insGTCTCGAACTCCGTGACCTCAGGTA | p.Met398ValfsTer18 | p.M398Vfs*18 | Q8N4N3 | protein_coding | TCGA-A8-A07Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unspecific | Exemestane | SD | ||
KLHL36 | insertion | Nonsense_Mutation | novel | c.617_618insAAAAAAGAAAGAAAGAAAGAAAGAAG | p.Cys206Ter | p.C206* | Q8N4N3 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
KLHL36 | insertion | Frame_Shift_Ins | novel | c.618_619insTATATTAATAA | p.Glu207TyrfsTer16 | p.E207Yfs*16 | Q8N4N3 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
KLHL36 | insertion | Frame_Shift_Ins | novel | c.1624_1625insT | p.Ala542ValfsTer110 | p.A542Vfs*110 | Q8N4N3 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
KLHL36 | insertion | Frame_Shift_Ins | novel | c.1625_1626insGCCGGCGGCAGCTTCTCACGGGACAACGG | p.Val543ProfsTer109 | p.V543Pfs*109 | Q8N4N3 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
KLHL36 | SNV | Missense_Mutation | novel | c.1735G>A | p.Val579Ile | p.V579I | Q8N4N3 | protein_coding | tolerated(0.12) | benign(0.052) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
KLHL36 | SNV | Missense_Mutation | c.576G>C | p.Lys192Asn | p.K192N | Q8N4N3 | protein_coding | deleterious(0.01) | probably_damaging(0.91) | TCGA-EK-A3GK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
KLHL36 | SNV | Missense_Mutation | novel | c.1189N>C | p.Asp397His | p.D397H | Q8N4N3 | protein_coding | deleterious(0.04) | probably_damaging(0.963) | TCGA-MA-AA41-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
KLHL36 | SNV | Missense_Mutation | novel | c.181N>T | p.Arg61Cys | p.R61C | Q8N4N3 | protein_coding | deleterious(0.04) | possibly_damaging(0.664) | TCGA-PN-A8MA-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
KLHL36 | SNV | Missense_Mutation | c.1569N>G | p.Cys523Trp | p.C523W | Q8N4N3 | protein_coding | deleterious(0.04) | probably_damaging(0.958) | TCGA-UC-A7PF-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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