Schematic overview of the cellular and molecular mechanisms involved in the cancer progression, including the proposed cellular and molecular mechanisms in cancer cells trajectory. AT1: alveolar type 1 cells; AT2: alveolar type 2 cells; AAH: atypical adenomatous hyperplasia; AIS: adenocarcinoma in situ; MIA: minimally invasive adenocarcinoma; IA: invasive adenocarcinoma; EMT: epithelial-mesenchymal transition

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Center for Computational Systems Medicine
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Gene summary

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Malignant transformation analysis

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Malignant transformation related pathway analysis

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Cell-cell communication analysis

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Single-cell gene regulatory network inference analysis

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Somatic mutation of malignant transformation related genes

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Related drugs of malignant transformation related genes

Gene: KLF5

Gene summary for KLF5

check button Gene summary.

Gene informationSpeciesHuman
Gene symbol

KLF5

Gene ID

688

Gene nameKruppel like factor 5
Gene AliasBTEB2
Cytomap13q22.1
Gene Typeprotein-coding
GO ID

GO:0000122

UniProtAcc

Q13887


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Malignant transformation analysis

check button Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells
check button Malignant transformation involving gene list.
Entrez IDSymbolReplicatesSpeciesOrganTissueAdj P-valueLog2FCMalignancy
688KLF5HTA11_99999965104_69814HumanColorectumMSS1.90e-076.64e-010.281
688KLF5HTA11_99999971662_82457HumanColorectumMSS1.14e-024.72e-010.3859
688KLF5HTA11_99999974143_84620HumanColorectumMSS9.06e-15-5.91e-010.3005
688KLF5F007HumanColorectumFAP2.20e-05-4.25e-010.1176
688KLF5A002-C-010HumanColorectumFAP3.14e-08-4.62e-010.242
688KLF5A001-C-207HumanColorectumFAP3.51e-13-5.81e-010.1278
688KLF5A015-C-203HumanColorectumFAP4.29e-40-7.00e-01-0.1294
688KLF5A015-C-204HumanColorectumFAP4.97e-10-4.81e-01-0.0228
688KLF5A014-C-040HumanColorectumFAP8.22e-05-3.79e-01-0.1184
688KLF5A002-C-201HumanColorectumFAP3.07e-27-6.76e-010.0324
688KLF5A002-C-203HumanColorectumFAP6.86e-07-3.65e-010.2786
688KLF5A001-C-119HumanColorectumFAP8.38e-18-7.56e-01-0.1557
688KLF5A001-C-108HumanColorectumFAP1.05e-25-6.33e-01-0.0272
688KLF5A002-C-205HumanColorectumFAP3.52e-38-7.10e-01-0.1236
688KLF5A001-C-104HumanColorectumFAP2.67e-05-4.28e-010.0184
688KLF5A015-C-005HumanColorectumFAP2.39e-04-3.01e-01-0.0336
688KLF5A015-C-006HumanColorectumFAP3.31e-29-8.46e-01-0.0994
688KLF5A015-C-106HumanColorectumFAP4.37e-17-5.01e-01-0.0511
688KLF5A002-C-114HumanColorectumFAP4.71e-28-5.81e-01-0.1561
688KLF5A015-C-104HumanColorectumFAP1.04e-42-6.83e-01-0.1899
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check button Transcriptomic changes along malignancy continuum.
TissueExpression DynamicsAbbreviation
CervixThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CC: Cervix cancer
HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions
N_HPV: HPV-infected normal cervix
Colorectum (GSE201348)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.FAP: Familial adenomatous polyposis
CRC: Colorectal cancer
Colorectum (HTA11)The image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AD: Adenomas
SER: Sessile serrated lesions
MSI-H: Microsatellite-high colorectal cancer
MSS: Microsatellite stable colorectal cancer
EndometriumThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AEH: Atypical endometrial hyperplasia
EEC: Endometrioid Cancer
EsophagusThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ESCC: Esophageal squamous cell carcinoma
HGIN: High-grade intraepithelial neoplasias
LGIN: Low-grade intraepithelial neoplasias
GCThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.CAG: Chronic atrophic gastritis
CAG with IM: Chronic atrophic gastritis with intestinal metaplasia
CSG: Chronic superficial gastritis
GC: Gastric cancer
SIM: Severe intestinal metaplasia
WIM: Wild intestinal metaplasia
LiverThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.HCC: Hepatocellular carcinoma
NAFLD: Non-alcoholic fatty liver disease
LungThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AAH: Atypical adenomatous hyperplasia
AIS: Adenocarcinoma in situ
IAC: Invasive lung adenocarcinoma
MIA: Minimally invasive adenocarcinoma
Oral CavityThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.EOLP: Erosive Oral lichen planus
LP: leukoplakia
NEOLP: Non-erosive oral lichen planus
OSCC: Oral squamous cell carcinoma
ProstateThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.BPH: Benign Prostatic Hyperplasia
SkinThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.AK: Actinic keratosis
cSCC: Cutaneous squamous cell carcinoma
SCCIS:squamous cell carcinoma in situ
ThyroidThe image shows the transcriptomic changes along malignancy continuum.log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.ATC: Anaplastic thyroid cancer
HT: Hashimoto's thyroiditis
PTC: Papillary thyroid cancer
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage.

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Malignant transformation related pathway analysis

check buttonFind out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer
check button Figure of enriched GO biological processes.
TissueDisease StageEnriched GO biological Processes
ColorectumADGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumSERGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSSGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumMSI-HGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
ColorectumFAPGO analysis - Figure of enriched GO biological processes: Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust).
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check button Enriched GO biological processes.
GO IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustCount
GO:00454445CervixCCfat cell differentiation53/2311229/187233.72e-069.75e-0553
GO:00616148CervixCCpri-miRNA transcription by RNA polymerase II20/231155/187234.22e-061.09e-0420
GO:19028938CervixCCregulation of pri-miRNA transcription by RNA polymerase II19/231154/187231.27e-052.60e-0419
GO:00310996CervixCCregeneration46/2311198/187231.43e-052.84e-0446
GO:19016538CervixCCcellular response to peptide72/2311359/187231.89e-053.48e-0472
GO:19028955CervixCCpositive regulation of pri-miRNA transcription by RNA polymerase II15/231142/187238.42e-051.13e-0315
GO:00605375CervixCCmuscle tissue development76/2311403/187239.76e-051.27e-0376
GO:00147064CervixCCstriated muscle tissue development72/2311384/187231.76e-042.07e-0372
GO:000206410CervixCCepithelial cell development45/2311220/187234.14e-044.21e-0345
GO:0045598CervixCCregulation of fat cell differentiation31/2311139/187237.06e-046.41e-0331
GO:00456004CervixCCpositive regulation of fat cell differentiation18/231166/187238.09e-047.07e-0318
GO:00426924CervixCCmuscle cell differentiation69/2311384/187238.12e-047.09e-0369
GO:0042246CervixCCtissue regeneration19/231172/187239.11e-047.81e-0319
GO:01200328CervixCCregulation of plasma membrane bounded cell projection assembly38/2311186/187231.14e-039.35e-0338
GO:00434032CervixCCskeletal muscle tissue regeneration12/231137/187231.15e-039.39e-0312
GO:00604917CervixCCregulation of cell projection assembly38/2311188/187231.40e-031.10e-0238
GO:00300337CervixCCmicrovillus assembly7/231116/187231.79e-031.34e-027
GO:19908234CervixCCresponse to leukemia inhibitory factor22/231195/187232.40e-031.70e-0222
GO:00075173CervixCCmuscle organ development58/2311327/187232.73e-031.85e-0258
GO:19908304CervixCCcellular response to leukemia inhibitory factor21/231194/187234.68e-032.82e-0221
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check button Enriched KEGG pathways.
Pathway IDTissueDisease StageDescriptionGene RatioBg Ratiopvaluep.adjustqvalueCount
hsa05207ColorectumCRCChemical carcinogenesis - receptor activation42/1091212/84652.62e-031.75e-021.19e-0242
hsa052071ColorectumCRCChemical carcinogenesis - receptor activation42/1091212/84652.62e-031.75e-021.19e-0242
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Cell-cell communication analysis

check buttonIdentification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states
LigandReceptorLRpairPathwayTissueDisease Stage
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Single-cell gene regulatory network inference analysis

check buttonFind out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states
TFCell TypeTissueDisease StageTarget GeneRSSRegulon Activity
KLF5MESCervixCCZFP36L1,CTNND1,MPZL2, etc.7.07e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5KEREsophagusHealthyCLDN1,FAM46A,VIM, etc.2.01e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5STMEsophagusHealthyCLDN1,FAM46A,VIM, etc.4.45e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5DUCT1PancreasPDACLMO7,TM9SF3,CYP3A5, etc.6.34e-01The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5CD8TRMPancreasADJMOB3A,FAM160A1,IL3RA, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5CD8TEREXPancreasADJMOB3A,FAM160A1,IL3RA, etc.5.23e-03The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5CD8TCMPancreasADJMOB3A,FAM160A1,IL3RA, etc.2.22e-16The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5TREGPancreasADJMOB3A,FAM160A1,IL3RA, etc.2.22e-16The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5CD8TEREXPancreasHealthyMOB3A,FAM160A1,IL3RA, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
KLF5TREGPancreasHealthyMOB3A,FAM160A1,IL3RA, etc.0.00e+00The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression.
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Somatic mutation of malignant transformation related genes

check buttonAnnotation of somatic variants for genes involved in malignant transformation
Hugo SymbolVariant ClassVariant ClassificationdbSNP RSHGVScHGVSpHGVSp ShortSWISSPROTBIOTYPESIFTPolyPhenTumor Sample BarcodeTissueHistologySexAgeStageTherapy TypesDrugsOutcome
KLF5deletionFrame_Shift_Delnovelc.280delNp.Lys94SerfsTer3p.K94Sfs*3Q13887protein_codingTCGA-EW-A2FV-01Breastbreast invasive carcinomaFemale<65III/IVChemotherapydocetaxelSD
KLF5SNVMissense_Mutationc.1255G>Ap.Glu419Lysp.E419KQ13887protein_codingdeleterious(0)probably_damaging(0.998)TCGA-EK-A2R8-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
KLF5SNVMissense_Mutationc.604N>Ap.Glu202Lysp.E202KQ13887protein_codingtolerated(0.78)benign(0)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
KLF5SNVMissense_Mutationc.1255N>Ap.Glu419Lysp.E419KQ13887protein_codingdeleterious(0)probably_damaging(0.998)TCGA-IR-A3LK-01Cervixcervical & endocervical cancerFemale>=65I/IIChemotherapycisplatinPD
KLF5SNVMissense_Mutationc.341G>Tp.Arg114Leup.R114LQ13887protein_codingdeleterious(0)probably_damaging(0.997)TCGA-IR-A3LL-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KLF5SNVMissense_Mutationc.1255N>Ap.Glu419Lysp.E419KQ13887protein_codingdeleterious(0)probably_damaging(0.998)TCGA-VS-A958-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinCR
KLF5SNVMissense_Mutationc.1255N>Ap.Glu419Lysp.E419KQ13887protein_codingdeleterious(0)probably_damaging(0.998)TCGA-VS-A959-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
KLF5SNVMissense_Mutationnovelc.1256N>Gp.Glu419Glyp.E419GQ13887protein_codingdeleterious(0)probably_damaging(0.999)TCGA-VS-A959-01Cervixcervical & endocervical cancerFemale>=65I/IIUnknownUnknownSD
KLF5SNVMissense_Mutationc.1255N>Ap.Glu419Lysp.E419KQ13887protein_codingdeleterious(0)probably_damaging(0.998)TCGA-VS-A9UC-01Cervixcervical & endocervical cancerFemale<65I/IIChemotherapycisplatinSD
KLF5deletionFrame_Shift_Delnovelc.282_288delGTATCTGp.Tyr95HisfsTer9p.Y95Hfs*9Q13887protein_codingTCGA-JW-A5VK-01Cervixcervical & endocervical cancerFemale<65I/IIUnknownUnknownSD
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Related drugs of malignant transformation related genes

check buttonIdentification of chemicals and drugs interact with genes involved in malignant transfromation
(DGIdb 4.0)
Entrez IDSymbolCategoryInteraction TypesDrug Claim NameDrug NamePMIDs
688KLF5TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOMEOUABAINOUABAIN
688KLF5TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOMECID 926663CHEMBL265686
688KLF5TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOMECID 838877CHEMBL405317
688KLF5TRANSCRIPTION FACTOR COMPLEX, TRANSCRIPTION FACTOR, DRUGGABLE GENOMETCMDC-125567CHEMBL530049
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