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Gene: KIF1BP |
Gene summary for KIF1BP |
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Gene information | Species | Human | Gene symbol | KIF1BP | Gene ID | 26128 |
Gene name | kinesin family binding protein | |
Gene Alias | KBP | |
Cytomap | 10q22.1 | |
Gene Type | protein-coding | GO ID | GO:0001701 | UniProtAcc | Q96EK5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26128 | KIF1BP | P28T-E | Human | Esophagus | ESCC | 3.39e-14 | 2.67e-01 | 0.1149 |
26128 | KIF1BP | P30T-E | Human | Esophagus | ESCC | 2.38e-03 | 2.05e-01 | 0.137 |
26128 | KIF1BP | P31T-E | Human | Esophagus | ESCC | 2.02e-09 | 1.28e-01 | 0.1251 |
26128 | KIF1BP | P32T-E | Human | Esophagus | ESCC | 1.63e-20 | 2.47e-01 | 0.1666 |
26128 | KIF1BP | P36T-E | Human | Esophagus | ESCC | 2.31e-10 | 2.38e-01 | 0.1187 |
26128 | KIF1BP | P37T-E | Human | Esophagus | ESCC | 8.01e-17 | 1.79e-01 | 0.1371 |
26128 | KIF1BP | P39T-E | Human | Esophagus | ESCC | 2.33e-05 | 6.16e-02 | 0.0894 |
26128 | KIF1BP | P40T-E | Human | Esophagus | ESCC | 2.56e-04 | 7.82e-02 | 0.109 |
26128 | KIF1BP | P42T-E | Human | Esophagus | ESCC | 3.73e-12 | 1.63e-01 | 0.1175 |
26128 | KIF1BP | P44T-E | Human | Esophagus | ESCC | 4.73e-12 | 1.69e-01 | 0.1096 |
26128 | KIF1BP | P47T-E | Human | Esophagus | ESCC | 6.94e-08 | 1.13e-01 | 0.1067 |
26128 | KIF1BP | P48T-E | Human | Esophagus | ESCC | 2.99e-08 | 1.36e-01 | 0.0959 |
26128 | KIF1BP | P49T-E | Human | Esophagus | ESCC | 2.78e-02 | 3.71e-01 | 0.1768 |
26128 | KIF1BP | P52T-E | Human | Esophagus | ESCC | 7.81e-15 | 2.67e-01 | 0.1555 |
26128 | KIF1BP | P54T-E | Human | Esophagus | ESCC | 8.93e-13 | 2.60e-01 | 0.0975 |
26128 | KIF1BP | P57T-E | Human | Esophagus | ESCC | 5.51e-10 | 1.51e-01 | 0.0926 |
26128 | KIF1BP | P61T-E | Human | Esophagus | ESCC | 4.69e-19 | 1.15e-01 | 0.099 |
26128 | KIF1BP | P62T-E | Human | Esophagus | ESCC | 9.58e-17 | 2.72e-01 | 0.1302 |
26128 | KIF1BP | P65T-E | Human | Esophagus | ESCC | 5.37e-15 | 1.16e-01 | 0.0978 |
26128 | KIF1BP | P74T-E | Human | Esophagus | ESCC | 7.70e-30 | 8.31e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIF1BP | SNV | Missense_Mutation | c.1786N>C | p.Glu596Gln | p.E596Q | Q96EK5 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A06Q-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | |
KIF1BP | SNV | Missense_Mutation | novel | c.1689N>T | p.Lys563Asn | p.K563N | Q96EK5 | protein_coding | tolerated(0.34) | benign(0.01) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
KIF1BP | SNV | Missense_Mutation | c.566C>T | p.Pro189Leu | p.P189L | Q96EK5 | protein_coding | tolerated(0.1) | benign(0.163) | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
KIF1BP | SNV | Missense_Mutation | rs757109189 | c.526N>T | p.Val176Phe | p.V176F | Q96EK5 | protein_coding | tolerated(0.08) | benign(0.033) | TCGA-AR-A0TR-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD |
KIF1BP | SNV | Missense_Mutation | rs374074903 | c.1621N>T | p.Arg541Cys | p.R541C | Q96EK5 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-D8-A27W-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | doxorubicine+cyclophosphamide | SD |
KIF1BP | insertion | Frame_Shift_Ins | novel | c.298_299insGT | p.His100ArgfsTer5 | p.H100Rfs*5 | Q96EK5 | protein_coding | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
KIF1BP | insertion | Nonsense_Mutation | novel | c.299_300insCACAGCTGGTGCTTAATAGTTAAAATCTTCTATCACC | p.Leu101ThrfsTer5 | p.L101Tfs*5 | Q96EK5 | protein_coding | TCGA-A8-A091-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | PD | ||
KIF1BP | deletion | Frame_Shift_Del | novel | c.1754delA | p.Lys585SerfsTer9 | p.K585Sfs*9 | Q96EK5 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
KIF1BP | SNV | Missense_Mutation | novel | c.1768N>C | p.Ala590Pro | p.A590P | Q96EK5 | protein_coding | tolerated(0.21) | benign(0.055) | TCGA-DS-A1OD-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
KIF1BP | SNV | Missense_Mutation | c.1213N>C | p.Glu405Gln | p.E405Q | Q96EK5 | protein_coding | tolerated(0.38) | benign(0.131) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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