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Gene: KIAA0907 |
Gene summary for KIAA0907 |
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Gene information | Species | Human | Gene symbol | KIAA0907 | Gene ID | 22889 |
Gene name | KH domain containing 4, pre-mRNA splicing factor | |
Gene Alias | BLOM7 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0000245 | UniProtAcc | Q7Z7F0 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
22889 | KIAA0907 | P22T-E | Human | Esophagus | ESCC | 1.14e-22 | 3.24e-01 | 0.1236 |
22889 | KIAA0907 | P23T-E | Human | Esophagus | ESCC | 1.21e-23 | 5.68e-01 | 0.108 |
22889 | KIAA0907 | P24T-E | Human | Esophagus | ESCC | 8.81e-13 | 3.13e-01 | 0.1287 |
22889 | KIAA0907 | P26T-E | Human | Esophagus | ESCC | 2.56e-24 | 4.25e-01 | 0.1276 |
22889 | KIAA0907 | P27T-E | Human | Esophagus | ESCC | 6.71e-15 | 4.31e-01 | 0.1055 |
22889 | KIAA0907 | P28T-E | Human | Esophagus | ESCC | 1.66e-51 | 9.07e-01 | 0.1149 |
22889 | KIAA0907 | P30T-E | Human | Esophagus | ESCC | 2.45e-26 | 1.07e+00 | 0.137 |
22889 | KIAA0907 | P31T-E | Human | Esophagus | ESCC | 9.55e-17 | 2.75e-01 | 0.1251 |
22889 | KIAA0907 | P32T-E | Human | Esophagus | ESCC | 2.34e-19 | 3.58e-01 | 0.1666 |
22889 | KIAA0907 | P36T-E | Human | Esophagus | ESCC | 8.55e-32 | 1.45e+00 | 0.1187 |
22889 | KIAA0907 | P37T-E | Human | Esophagus | ESCC | 5.71e-13 | 3.02e-01 | 0.1371 |
22889 | KIAA0907 | P39T-E | Human | Esophagus | ESCC | 7.69e-20 | 4.06e-01 | 0.0894 |
22889 | KIAA0907 | P40T-E | Human | Esophagus | ESCC | 7.79e-14 | 2.32e-01 | 0.109 |
22889 | KIAA0907 | P42T-E | Human | Esophagus | ESCC | 1.38e-17 | 5.13e-01 | 0.1175 |
22889 | KIAA0907 | P44T-E | Human | Esophagus | ESCC | 2.03e-07 | 1.81e-01 | 0.1096 |
22889 | KIAA0907 | P47T-E | Human | Esophagus | ESCC | 2.14e-28 | 5.33e-01 | 0.1067 |
22889 | KIAA0907 | P48T-E | Human | Esophagus | ESCC | 6.65e-20 | 4.02e-01 | 0.0959 |
22889 | KIAA0907 | P49T-E | Human | Esophagus | ESCC | 8.82e-07 | 1.07e+00 | 0.1768 |
22889 | KIAA0907 | P52T-E | Human | Esophagus | ESCC | 5.59e-27 | 4.87e-01 | 0.1555 |
22889 | KIAA0907 | P54T-E | Human | Esophagus | ESCC | 4.12e-19 | 5.25e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KIAA0907 | SNV | Missense_Mutation | c.917C>G | p.Ala306Gly | p.A306G | Q7Z7F0 | protein_coding | tolerated(0.09) | benign(0.208) | TCGA-A8-A09M-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | paclitaxel | CR | |
KIAA0907 | SNV | Missense_Mutation | novel | c.617A>C | p.His206Pro | p.H206P | Q7Z7F0 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-AO-A1KP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | SD |
KIAA0907 | SNV | Missense_Mutation | c.304N>G | p.Leu102Val | p.L102V | Q7Z7F0 | protein_coding | tolerated(0.14) | benign(0.188) | TCGA-AR-A256-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | PD | |
KIAA0907 | SNV | Missense_Mutation | c.968A>G | p.Tyr323Cys | p.Y323C | Q7Z7F0 | protein_coding | deleterious(0) | probably_damaging(0.973) | TCGA-BH-A18G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
KIAA0907 | SNV | Missense_Mutation | novel | c.617N>C | p.His206Pro | p.H206P | Q7Z7F0 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-D8-A1JI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine | SD |
KIAA0907 | SNV | Missense_Mutation | novel | c.617N>C | p.His206Pro | p.H206P | Q7Z7F0 | protein_coding | tolerated(0.35) | benign(0.003) | TCGA-D8-A1X7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | ChemotherapyHormone Therapy | doxorubicine+cyclophosphamide+tamoxifen | SD |
KIAA0907 | SNV | Missense_Mutation | c.1743N>A | p.His581Gln | p.H581Q | Q7Z7F0 | protein_coding | tolerated_low_confidence(0.17) | benign(0.005) | TCGA-D8-A1XK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicine+cyclophosphamide | SD | |
KIAA0907 | SNV | Missense_Mutation | novel | c.1394C>G | p.Thr465Arg | p.T465R | Q7Z7F0 | protein_coding | tolerated(0.16) | probably_damaging(0.994) | TCGA-PL-A8LV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KIAA0907 | insertion | Frame_Shift_Ins | novel | c.1618_1619insATCACACC | p.Gly540AspfsTer8 | p.G540Dfs*8 | Q7Z7F0 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
KIAA0907 | insertion | Frame_Shift_Ins | novel | c.1617_1618insCACTTGAACTTGGGAGGTGGAGGTTGCCGTGAGCCAA | p.Gly540HisfsTer22 | p.G540Hfs*22 | Q7Z7F0 | protein_coding | TCGA-A8-A08H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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