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Gene: KHNYN |
Gene summary for KHNYN |
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Gene information | Species | Human | Gene symbol | KHNYN | Gene ID | 23351 |
Gene name | KH and NYN domain containing | |
Gene Alias | KIAA0323 | |
Cytomap | 14q12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | O15037 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
23351 | KHNYN | P31T-E | Human | Esophagus | ESCC | 1.57e-11 | 1.40e-01 | 0.1251 |
23351 | KHNYN | P32T-E | Human | Esophagus | ESCC | 1.86e-02 | 4.05e-02 | 0.1666 |
23351 | KHNYN | P36T-E | Human | Esophagus | ESCC | 2.59e-02 | 1.20e-01 | 0.1187 |
23351 | KHNYN | P37T-E | Human | Esophagus | ESCC | 3.85e-11 | 1.98e-01 | 0.1371 |
23351 | KHNYN | P38T-E | Human | Esophagus | ESCC | 1.61e-02 | 1.32e-01 | 0.127 |
23351 | KHNYN | P39T-E | Human | Esophagus | ESCC | 1.24e-07 | 9.33e-02 | 0.0894 |
23351 | KHNYN | P42T-E | Human | Esophagus | ESCC | 1.67e-04 | 1.68e-01 | 0.1175 |
23351 | KHNYN | P47T-E | Human | Esophagus | ESCC | 6.13e-15 | 1.65e-01 | 0.1067 |
23351 | KHNYN | P48T-E | Human | Esophagus | ESCC | 4.75e-10 | 1.56e-01 | 0.0959 |
23351 | KHNYN | P49T-E | Human | Esophagus | ESCC | 4.57e-04 | 6.14e-01 | 0.1768 |
23351 | KHNYN | P52T-E | Human | Esophagus | ESCC | 1.63e-09 | 1.48e-01 | 0.1555 |
23351 | KHNYN | P54T-E | Human | Esophagus | ESCC | 1.65e-06 | 1.58e-01 | 0.0975 |
23351 | KHNYN | P56T-E | Human | Esophagus | ESCC | 2.89e-03 | 4.34e-01 | 0.1613 |
23351 | KHNYN | P57T-E | Human | Esophagus | ESCC | 2.05e-11 | 1.98e-01 | 0.0926 |
23351 | KHNYN | P61T-E | Human | Esophagus | ESCC | 1.39e-16 | 4.03e-01 | 0.099 |
23351 | KHNYN | P62T-E | Human | Esophagus | ESCC | 2.88e-11 | 2.08e-01 | 0.1302 |
23351 | KHNYN | P65T-E | Human | Esophagus | ESCC | 1.65e-07 | 1.54e-01 | 0.0978 |
23351 | KHNYN | P74T-E | Human | Esophagus | ESCC | 7.65e-17 | 4.33e-01 | 0.1479 |
23351 | KHNYN | P75T-E | Human | Esophagus | ESCC | 5.23e-20 | 4.09e-01 | 0.1125 |
23351 | KHNYN | P76T-E | Human | Esophagus | ESCC | 3.24e-03 | 2.95e-02 | 0.1207 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00905013 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis | 110/8552 | 152/18723 | 1.95e-11 | 6.81e-10 | 110 |
GO:00903053 | Esophagus | ESCC | nucleic acid phosphodiester bond hydrolysis | 163/8552 | 261/18723 | 3.07e-08 | 5.73e-07 | 163 |
GO:00905023 | Esophagus | ESCC | RNA phosphodiester bond hydrolysis, endonucleolytic | 55/8552 | 82/18723 | 7.34e-05 | 5.51e-04 | 55 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KHNYN | SNV | Missense_Mutation | c.368N>T | p.Gly123Val | p.G123V | O15037 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AR-A1AN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
KHNYN | insertion | Nonsense_Mutation | novel | c.482_483insCCCCATGTGGAGCGCATCTTCAGCGTGGGGGTGAGCGTCCTTCCGAAG | p.Leu161_Arg162insProMetTrpSerAlaSerSerAlaTrpGlyTerAlaSerPheArgArg | p.L161_R162insPMWSASSAWG*ASFRR | O15037 | protein_coding | TCGA-A8-A0A4-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | CR | ||
KHNYN | insertion | Nonsense_Mutation | novel | c.1620_1621insTCAGTGGTGAAGTCTAGGCTTTTAATGTAACCATGA | p.Ser541_Asn542insValValLysSerArgLeuLeuMetTerProTerSer | p.S541_N542insVVKSRLLM*P*S | O15037 | protein_coding | TCGA-AN-A041-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
KHNYN | deletion | Frame_Shift_Del | novel | c.1717delN | p.Phe573SerfsTer19 | p.F573Sfs*19 | O15037 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
KHNYN | SNV | Missense_Mutation | novel | c.1157G>T | p.Gly386Val | p.G386V | O15037 | protein_coding | deleterious(0.01) | benign(0.276) | TCGA-VS-A8QC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | PD |
KHNYN | SNV | Missense_Mutation | c.338C>A | p.Pro113His | p.P113H | O15037 | protein_coding | deleterious(0.02) | probably_damaging(0.946) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
KHNYN | SNV | Missense_Mutation | novel | c.1922A>G | p.Gln641Arg | p.Q641R | O15037 | protein_coding | deleterious(0.04) | possibly_damaging(0.622) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
KHNYN | SNV | Missense_Mutation | c.1159N>A | p.Asp387Asn | p.D387N | O15037 | protein_coding | deleterious(0.04) | possibly_damaging(0.655) | TCGA-AD-6890-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
KHNYN | SNV | Missense_Mutation | c.1244G>A | p.Arg415His | p.R415H | O15037 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KHNYN | SNV | Missense_Mutation | novel | c.656C>A | p.Ala219Asp | p.A219D | O15037 | protein_coding | tolerated(0.18) | benign(0.003) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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