![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: KDSR |
Gene summary for KDSR |
![]() |
Gene information | Species | Human | Gene symbol | KDSR | Gene ID | 2531 |
Gene name | 3-ketodihydrosphingosine reductase | |
Gene Alias | DHSR | |
Cytomap | 18q21.33 | |
Gene Type | protein-coding | GO ID | GO:0006629 | UniProtAcc | A0A024R292 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2531 | KDSR | LZE21T | Human | Esophagus | ESCC | 2.47e-02 | 7.70e-02 | 0.0655 |
2531 | KDSR | P1T-E | Human | Esophagus | ESCC | 3.68e-07 | 6.95e-01 | 0.0875 |
2531 | KDSR | P2T-E | Human | Esophagus | ESCC | 4.58e-33 | 7.15e-01 | 0.1177 |
2531 | KDSR | P4T-E | Human | Esophagus | ESCC | 9.16e-29 | 7.26e-01 | 0.1323 |
2531 | KDSR | P5T-E | Human | Esophagus | ESCC | 2.17e-13 | 1.95e-01 | 0.1327 |
2531 | KDSR | P8T-E | Human | Esophagus | ESCC | 2.39e-26 | 7.47e-01 | 0.0889 |
2531 | KDSR | P9T-E | Human | Esophagus | ESCC | 3.03e-13 | 3.42e-01 | 0.1131 |
2531 | KDSR | P10T-E | Human | Esophagus | ESCC | 3.36e-23 | 5.89e-01 | 0.116 |
2531 | KDSR | P11T-E | Human | Esophagus | ESCC | 2.48e-12 | 8.31e-01 | 0.1426 |
2531 | KDSR | P12T-E | Human | Esophagus | ESCC | 1.41e-19 | 5.99e-01 | 0.1122 |
2531 | KDSR | P15T-E | Human | Esophagus | ESCC | 4.95e-16 | 2.00e-01 | 0.1149 |
2531 | KDSR | P16T-E | Human | Esophagus | ESCC | 1.21e-18 | 5.17e-01 | 0.1153 |
2531 | KDSR | P17T-E | Human | Esophagus | ESCC | 7.42e-04 | 3.10e-01 | 0.1278 |
2531 | KDSR | P19T-E | Human | Esophagus | ESCC | 9.49e-06 | 9.92e-01 | 0.1662 |
2531 | KDSR | P20T-E | Human | Esophagus | ESCC | 2.27e-22 | 5.98e-01 | 0.1124 |
2531 | KDSR | P21T-E | Human | Esophagus | ESCC | 4.82e-41 | 9.58e-01 | 0.1617 |
2531 | KDSR | P22T-E | Human | Esophagus | ESCC | 4.90e-23 | 2.25e-01 | 0.1236 |
2531 | KDSR | P23T-E | Human | Esophagus | ESCC | 2.31e-28 | 8.79e-01 | 0.108 |
2531 | KDSR | P24T-E | Human | Esophagus | ESCC | 1.49e-10 | 2.23e-01 | 0.1287 |
2531 | KDSR | P26T-E | Human | Esophagus | ESCC | 1.59e-54 | 1.33e+00 | 0.1276 |
Page: 1 2 3 4 5 6 7 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0046519 | Colorectum | FAP | sphingoid metabolic process | 8/2622 | 21/18723 | 5.43e-03 | 3.53e-02 | 8 |
GO:00465191 | Colorectum | CRC | sphingoid metabolic process | 7/2078 | 21/18723 | 5.85e-03 | 4.32e-02 | 7 |
GO:00066433 | Esophagus | ESCC | membrane lipid metabolic process | 130/8552 | 203/18723 | 9.29e-08 | 1.54e-06 | 130 |
GO:00464673 | Esophagus | ESCC | membrane lipid biosynthetic process | 91/8552 | 142/18723 | 7.19e-06 | 7.19e-05 | 91 |
GO:00066652 | Esophagus | ESCC | sphingolipid metabolic process | 96/8552 | 155/18723 | 3.21e-05 | 2.66e-04 | 96 |
GO:00421805 | Esophagus | ESCC | cellular ketone metabolic process | 120/8552 | 211/18723 | 6.70e-04 | 3.55e-03 | 120 |
GO:00301481 | Esophagus | ESCC | sphingolipid biosynthetic process | 62/8552 | 103/18723 | 2.10e-03 | 9.38e-03 | 62 |
GO:004218011 | Liver | Cirrhotic | cellular ketone metabolic process | 80/4634 | 211/18723 | 1.40e-05 | 1.95e-04 | 80 |
GO:0006643 | Liver | Cirrhotic | membrane lipid metabolic process | 69/4634 | 203/18723 | 1.89e-03 | 1.19e-02 | 69 |
GO:004218021 | Liver | HCC | cellular ketone metabolic process | 123/7958 | 211/18723 | 2.52e-06 | 3.37e-05 | 123 |
GO:00066431 | Liver | HCC | membrane lipid metabolic process | 115/7958 | 203/18723 | 3.17e-05 | 3.22e-04 | 115 |
GO:0006665 | Liver | HCC | sphingolipid metabolic process | 85/7958 | 155/18723 | 1.27e-03 | 6.92e-03 | 85 |
GO:0046467 | Liver | HCC | membrane lipid biosynthetic process | 78/7958 | 142/18723 | 1.85e-03 | 9.46e-03 | 78 |
GO:00066432 | Oral cavity | OSCC | membrane lipid metabolic process | 111/7305 | 203/18723 | 4.02e-06 | 4.69e-05 | 111 |
GO:00421804 | Oral cavity | OSCC | cellular ketone metabolic process | 111/7305 | 211/18723 | 3.94e-05 | 3.45e-04 | 111 |
GO:00066651 | Oral cavity | OSCC | sphingolipid metabolic process | 84/7305 | 155/18723 | 8.64e-05 | 6.61e-04 | 84 |
GO:00464672 | Oral cavity | OSCC | membrane lipid biosynthetic process | 77/7305 | 142/18723 | 1.63e-04 | 1.13e-03 | 77 |
GO:0030148 | Oral cavity | OSCC | sphingolipid biosynthetic process | 53/7305 | 103/18723 | 6.81e-03 | 2.53e-02 | 53 |
GO:000664311 | Oral cavity | LP | membrane lipid metabolic process | 69/4623 | 203/18723 | 1.77e-03 | 1.34e-02 | 69 |
GO:004218012 | Oral cavity | LP | cellular ketone metabolic process | 70/4623 | 211/18723 | 3.29e-03 | 2.21e-02 | 70 |
Page: 1 2 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa006003 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa0060012 | Esophagus | ESCC | Sphingolipid metabolism | 36/4205 | 53/8465 | 5.41e-03 | 1.36e-02 | 6.99e-03 | 36 |
hsa00600 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa006001 | Liver | HCC | Sphingolipid metabolism | 34/4020 | 53/8465 | 1.06e-02 | 2.71e-02 | 1.51e-02 | 34 |
hsa006002 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
hsa0060011 | Oral cavity | OSCC | Sphingolipid metabolism | 33/3704 | 53/8465 | 5.00e-03 | 1.20e-02 | 6.13e-03 | 33 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
KDSR | insertion | Frame_Shift_Ins | novel | c.364_365insTGCGCCGTCTAGACAGACTTTCCCTTAAACCTCT | p.Ala122ValfsTer21 | p.A122Vfs*21 | Q06136 | protein_coding | TCGA-AN-A0AL-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD | ||
KDSR | SNV | Missense_Mutation | c.219N>C | p.Lys73Asn | p.K73N | Q06136 | protein_coding | deleterious(0.01) | possibly_damaging(0.624) | TCGA-EK-A2PG-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
KDSR | SNV | Missense_Mutation | rs750015953 | c.901N>T | p.Arg301Cys | p.R301C | Q06136 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AA-3833-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KDSR | SNV | Missense_Mutation | rs141264328 | c.902N>A | p.Arg301His | p.R301H | Q06136 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-AY-A69D-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
KDSR | SNV | Missense_Mutation | c.827C>T | p.Ala276Val | p.A276V | Q06136 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-F4-6703-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
KDSR | SNV | Missense_Mutation | novel | c.284C>T | p.Ser95Phe | p.S95F | Q06136 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
KDSR | SNV | Missense_Mutation | rs768170793 | c.487C>T | p.Arg163Cys | p.R163C | Q06136 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AJ-A3BG-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
KDSR | SNV | Missense_Mutation | novel | c.299A>G | p.Gln100Arg | p.Q100R | Q06136 | protein_coding | tolerated(0.28) | benign(0.267) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
KDSR | SNV | Missense_Mutation | c.193A>C | p.Asn65His | p.N65H | Q06136 | protein_coding | deleterious(0) | probably_damaging(0.917) | TCGA-AX-A05Z-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | SD | |
KDSR | SNV | Missense_Mutation | c.818N>C | p.Met273Thr | p.M273T | Q06136 | protein_coding | deleterious(0) | possibly_damaging(0.526) | TCGA-B5-A0JR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |