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Gene: ITPRIPL2 |
Gene summary for ITPRIPL2 |
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Gene information | Species | Human | Gene symbol | ITPRIPL2 | Gene ID | 162073 |
Gene name | ITPRIP like 2 | |
Gene Alias | ITPRIPL2 | |
Cytomap | 16p12.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q3MIP1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
162073 | ITPRIPL2 | P27T-E | Human | Esophagus | ESCC | 2.75e-12 | 8.40e-02 | 0.1055 |
162073 | ITPRIPL2 | P28T-E | Human | Esophagus | ESCC | 1.07e-14 | 2.72e-01 | 0.1149 |
162073 | ITPRIPL2 | P30T-E | Human | Esophagus | ESCC | 5.43e-11 | 4.26e-01 | 0.137 |
162073 | ITPRIPL2 | P31T-E | Human | Esophagus | ESCC | 1.82e-03 | 4.41e-02 | 0.1251 |
162073 | ITPRIPL2 | P32T-E | Human | Esophagus | ESCC | 1.23e-10 | 7.08e-02 | 0.1666 |
162073 | ITPRIPL2 | P36T-E | Human | Esophagus | ESCC | 1.42e-04 | 2.58e-01 | 0.1187 |
162073 | ITPRIPL2 | P37T-E | Human | Esophagus | ESCC | 2.39e-09 | 2.59e-01 | 0.1371 |
162073 | ITPRIPL2 | P39T-E | Human | Esophagus | ESCC | 3.96e-10 | 1.78e-01 | 0.0894 |
162073 | ITPRIPL2 | P42T-E | Human | Esophagus | ESCC | 5.35e-07 | 2.41e-01 | 0.1175 |
162073 | ITPRIPL2 | P47T-E | Human | Esophagus | ESCC | 1.66e-06 | 1.41e-01 | 0.1067 |
162073 | ITPRIPL2 | P48T-E | Human | Esophagus | ESCC | 2.62e-05 | 1.48e-01 | 0.0959 |
162073 | ITPRIPL2 | P49T-E | Human | Esophagus | ESCC | 1.88e-05 | 4.66e-01 | 0.1768 |
162073 | ITPRIPL2 | P52T-E | Human | Esophagus | ESCC | 9.41e-08 | 1.44e-01 | 0.1555 |
162073 | ITPRIPL2 | P54T-E | Human | Esophagus | ESCC | 9.64e-21 | 5.13e-01 | 0.0975 |
162073 | ITPRIPL2 | P57T-E | Human | Esophagus | ESCC | 1.85e-05 | 9.18e-02 | 0.0926 |
162073 | ITPRIPL2 | P61T-E | Human | Esophagus | ESCC | 6.43e-07 | 2.22e-01 | 0.099 |
162073 | ITPRIPL2 | P62T-E | Human | Esophagus | ESCC | 7.55e-45 | 9.21e-01 | 0.1302 |
162073 | ITPRIPL2 | P65T-E | Human | Esophagus | ESCC | 7.73e-07 | 1.29e-01 | 0.0978 |
162073 | ITPRIPL2 | P74T-E | Human | Esophagus | ESCC | 2.42e-04 | 1.00e-01 | 0.1479 |
162073 | ITPRIPL2 | P75T-E | Human | Esophagus | ESCC | 8.98e-32 | 4.95e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITPRIPL2 | SNV | Missense_Mutation | novel | c.1279N>A | p.Glu427Lys | p.E427K | Q3MIP1 | protein_coding | tolerated(0.09) | benign(0.251) | TCGA-A7-A6VX-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | docetaxel | CR |
ITPRIPL2 | insertion | Frame_Shift_Ins | novel | c.1337_1338insCAGGAACGGGCAGCTCCAGGTGCCTGCTACCTCAA | p.Arg448AsnfsTer37 | p.R448Nfs*37 | Q3MIP1 | protein_coding | TCGA-A8-A0A7-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
ITPRIPL2 | insertion | In_Frame_Ins | novel | c.882_883insTCACTGCAGCCT | p.Cys294_Arg295insSerLeuGlnPro | p.C294_R295insSLQP | Q3MIP1 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD | ||
ITPRIPL2 | insertion | Frame_Shift_Ins | novel | c.941_942insACAACAAACAAACAAACAAACAAAAACAGGAAAGGCTCTCTTTTCT | p.His314GlnfsTer41 | p.H314Qfs*41 | Q3MIP1 | protein_coding | TCGA-BH-A0B1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | adriamycin | SD | ||
ITPRIPL2 | deletion | Frame_Shift_Del | novel | c.1513delC | p.Gln505SerfsTer34 | p.Q505Sfs*34 | Q3MIP1 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
ITPRIPL2 | SNV | Missense_Mutation | novel | c.782G>A | p.Arg261His | p.R261H | Q3MIP1 | protein_coding | deleterious(0.04) | probably_damaging(0.996) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ITPRIPL2 | SNV | Missense_Mutation | c.1586G>T | p.Gly529Val | p.G529V | Q3MIP1 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.881) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
ITPRIPL2 | SNV | Missense_Mutation | c.170N>A | p.Leu57His | p.L57H | Q3MIP1 | protein_coding | deleterious(0) | possibly_damaging(0.907) | TCGA-AA-3821-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
ITPRIPL2 | SNV | Missense_Mutation | c.883C>T | p.Arg295Cys | p.R295C | Q3MIP1 | protein_coding | deleterious(0) | possibly_damaging(0.535) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
ITPRIPL2 | SNV | Missense_Mutation | c.1370N>A | p.Gly457Asp | p.G457D | Q3MIP1 | protein_coding | deleterious(0) | probably_damaging(0.976) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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