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Gene: ITM2C |
Gene summary for ITM2C |
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Gene information | Species | Human | Gene symbol | ITM2C | Gene ID | 81618 |
Gene name | integral membrane protein 2C | |
Gene Alias | BRI3 | |
Cytomap | 2q37.1 | |
Gene Type | protein-coding | GO ID | GO:0006807 | UniProtAcc | Q9NQX7 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
81618 | ITM2C | HTA11_7663_2000001011 | Human | Colorectum | SER | 3.02e-13 | 1.19e+00 | 0.0131 |
81618 | ITM2C | HTA11_10623_2000001011 | Human | Colorectum | AD | 6.17e-19 | 1.24e+00 | -0.0177 |
81618 | ITM2C | HTA11_6801_2000001011 | Human | Colorectum | SER | 3.58e-20 | 1.92e+00 | 0.0171 |
81618 | ITM2C | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.84e-05 | 4.59e-01 | 0.0338 |
81618 | ITM2C | HTA11_7696_3000711011 | Human | Colorectum | AD | 4.36e-20 | 7.95e-01 | 0.0674 |
81618 | ITM2C | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.50e-11 | 9.91e-01 | 0.0112 |
81618 | ITM2C | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.71e-22 | 1.74e+00 | -0.0124 |
81618 | ITM2C | HTA11_11156_2000001011 | Human | Colorectum | AD | 9.09e-04 | 1.06e+00 | 0.0397 |
81618 | ITM2C | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.93e-03 | 4.37e-01 | 0.0588 |
81618 | ITM2C | HTA11_99999965104_69814 | Human | Colorectum | MSS | 1.75e-03 | 4.01e-01 | 0.281 |
81618 | ITM2C | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.22e-03 | 5.12e-01 | 0.2585 |
81618 | ITM2C | A001-C-207 | Human | Colorectum | FAP | 2.63e-02 | -3.48e-01 | 0.1278 |
81618 | ITM2C | A015-C-203 | Human | Colorectum | FAP | 5.14e-10 | -3.27e-01 | -0.1294 |
81618 | ITM2C | A002-C-201 | Human | Colorectum | FAP | 1.19e-05 | -3.50e-01 | 0.0324 |
81618 | ITM2C | A002-C-203 | Human | Colorectum | FAP | 1.91e-06 | -2.94e-01 | 0.2786 |
81618 | ITM2C | A001-C-108 | Human | Colorectum | FAP | 1.03e-08 | -3.14e-01 | -0.0272 |
81618 | ITM2C | A002-C-205 | Human | Colorectum | FAP | 1.66e-04 | -3.17e-01 | -0.1236 |
81618 | ITM2C | A001-C-104 | Human | Colorectum | FAP | 2.73e-06 | -2.98e-01 | 0.0184 |
81618 | ITM2C | A015-C-006 | Human | Colorectum | FAP | 7.57e-04 | -3.65e-01 | -0.0994 |
81618 | ITM2C | A015-C-106 | Human | Colorectum | FAP | 5.22e-10 | -3.37e-01 | -0.0511 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:2001233 | Colorectum | AD | regulation of apoptotic signaling pathway | 119/3918 | 356/18723 | 2.14e-08 | 1.21e-06 | 119 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0097191 | Colorectum | AD | extrinsic apoptotic signaling pathway | 68/3918 | 219/18723 | 2.64e-04 | 3.27e-03 | 68 |
GO:0031345 | Colorectum | AD | negative regulation of cell projection organization | 58/3918 | 186/18723 | 6.37e-04 | 6.58e-03 | 58 |
GO:2001235 | Colorectum | AD | positive regulation of apoptotic signaling pathway | 42/3918 | 126/18723 | 7.85e-04 | 7.84e-03 | 42 |
GO:0010977 | Colorectum | AD | negative regulation of neuron projection development | 43/3918 | 137/18723 | 2.60e-03 | 1.97e-02 | 43 |
GO:20012331 | Colorectum | SER | regulation of apoptotic signaling pathway | 101/2897 | 356/18723 | 3.05e-10 | 4.07e-08 | 101 |
GO:00971911 | Colorectum | SER | extrinsic apoptotic signaling pathway | 58/2897 | 219/18723 | 1.76e-05 | 5.22e-04 | 58 |
GO:20012351 | Colorectum | SER | positive regulation of apoptotic signaling pathway | 36/2897 | 126/18723 | 1.29e-04 | 2.63e-03 | 36 |
GO:2001236 | Colorectum | SER | regulation of extrinsic apoptotic signaling pathway | 39/2897 | 151/18723 | 6.67e-04 | 8.94e-03 | 39 |
GO:00109751 | Colorectum | SER | regulation of neuron projection development | 92/2897 | 445/18723 | 1.85e-03 | 1.89e-02 | 92 |
GO:00313451 | Colorectum | SER | negative regulation of cell projection organization | 42/2897 | 186/18723 | 6.51e-03 | 4.66e-02 | 42 |
GO:20012332 | Colorectum | MSS | regulation of apoptotic signaling pathway | 116/3467 | 356/18723 | 1.02e-10 | 1.06e-08 | 116 |
GO:20012352 | Colorectum | MSS | positive regulation of apoptotic signaling pathway | 42/3467 | 126/18723 | 4.95e-05 | 8.97e-04 | 42 |
GO:00109752 | Colorectum | MSS | regulation of neuron projection development | 115/3467 | 445/18723 | 6.91e-05 | 1.20e-03 | 115 |
GO:00971912 | Colorectum | MSS | extrinsic apoptotic signaling pathway | 63/3467 | 219/18723 | 1.34e-04 | 2.03e-03 | 63 |
GO:00313452 | Colorectum | MSS | negative regulation of cell projection organization | 54/3467 | 186/18723 | 3.03e-04 | 3.96e-03 | 54 |
GO:00109771 | Colorectum | MSS | negative regulation of neuron projection development | 39/3467 | 137/18723 | 2.86e-03 | 2.22e-02 | 39 |
GO:20012361 | Colorectum | MSS | regulation of extrinsic apoptotic signaling pathway | 42/3467 | 151/18723 | 3.23e-03 | 2.45e-02 | 42 |
GO:00109753 | Colorectum | FAP | regulation of neuron projection development | 102/2622 | 445/18723 | 2.04e-07 | 1.24e-05 | 102 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
ITM2C | SNV | Missense_Mutation | rs764555891 | c.283N>T | p.Arg95Cys | p.R95C | Q9NQX7 | protein_coding | tolerated(0.09) | benign(0.288) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITM2C | SNV | Missense_Mutation | rs748390195 | c.499N>A | p.Glu167Lys | p.E167K | Q9NQX7 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
ITM2C | SNV | Missense_Mutation | rs760386716 | c.383G>A | p.Arg128His | p.R128H | Q9NQX7 | protein_coding | tolerated(0.54) | benign(0.003) | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITM2C | SNV | Missense_Mutation | rs200266468 | c.751N>T | p.Arg251Cys | p.R251C | Q9NQX7 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD |
ITM2C | SNV | Missense_Mutation | c.637G>A | p.Ala213Thr | p.A213T | Q9NQX7 | protein_coding | tolerated(0.18) | benign(0.011) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
ITM2C | SNV | Missense_Mutation | rs143044408 | c.695N>A | p.Arg232His | p.R232H | Q9NQX7 | protein_coding | deleterious(0.01) | probably_damaging(0.959) | TCGA-EI-6514-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Chemotherapy | 5-fu | SD |
ITM2C | SNV | Missense_Mutation | rs769890271 | c.217N>A | p.Val73Met | p.V73M | Q9NQX7 | protein_coding | deleterious(0) | possibly_damaging(0.499) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
ITM2C | deletion | Frame_Shift_Del | c.158delG | p.Gly53AlafsTer66 | p.G53Afs*66 | Q9NQX7 | protein_coding | TCGA-AD-A5EJ-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |||
ITM2C | SNV | Missense_Mutation | rs748390195 | c.499N>A | p.Glu167Lys | p.E167K | Q9NQX7 | protein_coding | tolerated(0.07) | probably_damaging(0.996) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
ITM2C | SNV | Missense_Mutation | rs769890271 | c.217N>A | p.Val73Met | p.V73M | Q9NQX7 | protein_coding | deleterious(0) | possibly_damaging(0.499) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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