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Gene: IL1RAPL1 |
Gene summary for IL1RAPL1 |
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Gene information | Species | Human | Gene symbol | IL1RAPL1 | Gene ID | 11141 |
Gene name | interleukin 1 receptor accessory protein like 1 | |
Gene Alias | IL-1-RAPL-1 | |
Cytomap | Xp21.3-p21.2 | |
Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NZN1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
11141 | IL1RAPL1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 2.35e-13 | 1.02e+00 | 0.0446 |
11141 | IL1RAPL1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.91e-16 | 9.67e-01 | 0.0528 |
11141 | IL1RAPL1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 2.69e-25 | 1.44e+00 | 0.0131 |
11141 | IL1RAPL1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 7.91e-05 | 4.41e-01 | -0.0177 |
11141 | IL1RAPL1 | HTA11_6801_2000001011 | Human | Colorectum | SER | 1.38e-11 | 8.79e-01 | 0.0171 |
11141 | IL1RAPL1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 7.88e-10 | 4.92e-01 | 0.0338 |
11141 | IL1RAPL1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.92e-42 | 8.66e-01 | 0.0674 |
11141 | IL1RAPL1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 5.36e-27 | 1.35e+00 | 0.0112 |
11141 | IL1RAPL1 | HTA11_7469_2000001011 | Human | Colorectum | AD | 5.46e-11 | 1.01e+00 | -0.0124 |
11141 | IL1RAPL1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 1.37e-07 | 7.70e-01 | 0.0397 |
11141 | IL1RAPL1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 1.74e-36 | 1.28e+00 | 0.0588 |
11141 | IL1RAPL1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 9.17e-50 | 1.08e+00 | 0.294 |
11141 | IL1RAPL1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 1.40e-13 | 1.47e+00 | 0.3487 |
11141 | IL1RAPL1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 3.59e-17 | 6.19e-01 | 0.281 |
11141 | IL1RAPL1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.55e-62 | 1.35e+00 | 0.3859 |
11141 | IL1RAPL1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 3.53e-14 | 8.97e-01 | 0.2585 |
11141 | IL1RAPL1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 7.99e-33 | 6.36e-01 | 0.3005 |
11141 | IL1RAPL1 | 048752_1579-all-cells | Human | Prostate | BPH | 3.81e-21 | 6.10e-01 | 0.1008 |
11141 | IL1RAPL1 | 052095_1628-all-cells | Human | Prostate | BPH | 1.44e-18 | 4.88e-01 | 0.1032 |
11141 | IL1RAPL1 | 052097_1595-all-cells | Human | Prostate | BPH | 1.05e-05 | 1.96e-01 | 0.0972 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0022604 | Colorectum | AD | regulation of cell morphogenesis | 109/3918 | 309/18723 | 3.08e-09 | 2.07e-07 | 109 |
GO:0034329 | Colorectum | AD | cell junction assembly | 136/3918 | 420/18723 | 2.02e-08 | 1.15e-06 | 136 |
GO:0010975 | Colorectum | AD | regulation of neuron projection development | 129/3918 | 445/18723 | 2.88e-05 | 5.37e-04 | 129 |
GO:0031346 | Colorectum | AD | positive regulation of cell projection organization | 104/3918 | 353/18723 | 8.26e-05 | 1.30e-03 | 104 |
GO:0071709 | Colorectum | AD | membrane assembly | 22/3918 | 50/18723 | 2.00e-04 | 2.66e-03 | 22 |
GO:0010769 | Colorectum | AD | regulation of cell morphogenesis involved in differentiation | 35/3918 | 96/18723 | 3.26e-04 | 3.85e-03 | 35 |
GO:0010770 | Colorectum | AD | positive regulation of cell morphogenesis involved in differentiation | 30/3918 | 79/18723 | 3.81e-04 | 4.38e-03 | 30 |
GO:0010720 | Colorectum | AD | positive regulation of cell development | 87/3918 | 298/18723 | 4.17e-04 | 4.71e-03 | 87 |
GO:0044091 | Colorectum | AD | membrane biogenesis | 22/3918 | 55/18723 | 9.88e-04 | 9.28e-03 | 22 |
GO:1901888 | Colorectum | AD | regulation of cell junction assembly | 61/3918 | 204/18723 | 1.50e-03 | 1.27e-02 | 61 |
GO:0050767 | Colorectum | AD | regulation of neurogenesis | 99/3918 | 364/18723 | 2.35e-03 | 1.82e-02 | 99 |
GO:0099173 | Colorectum | AD | postsynapse organization | 51/3918 | 168/18723 | 2.47e-03 | 1.90e-02 | 51 |
GO:0006887 | Colorectum | AD | exocytosis | 96/3918 | 352/18723 | 2.48e-03 | 1.90e-02 | 96 |
GO:0017157 | Colorectum | AD | regulation of exocytosis | 59/3918 | 202/18723 | 3.20e-03 | 2.36e-02 | 59 |
GO:0016358 | Colorectum | AD | dendrite development | 69/3918 | 243/18723 | 3.32e-03 | 2.42e-02 | 69 |
GO:0050808 | Colorectum | AD | synapse organization | 112/3918 | 426/18723 | 4.25e-03 | 2.92e-02 | 112 |
GO:0050807 | Colorectum | AD | regulation of synapse organization | 60/3918 | 211/18723 | 5.67e-03 | 3.64e-02 | 60 |
GO:00226041 | Colorectum | SER | regulation of cell morphogenesis | 89/2897 | 309/18723 | 1.51e-09 | 1.52e-07 | 89 |
GO:00343291 | Colorectum | SER | cell junction assembly | 100/2897 | 420/18723 | 4.23e-06 | 1.61e-04 | 100 |
GO:00717091 | Colorectum | SER | membrane assembly | 20/2897 | 50/18723 | 2.45e-05 | 6.84e-04 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IL1RAPL1 | SNV | Missense_Mutation | c.2088N>T | p.Trp696Cys | p.W696C | Q9NZN1 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.991) | TCGA-A2-A04P-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | taxol | PD | |
IL1RAPL1 | SNV | Missense_Mutation | c.848G>T | p.Trp283Leu | p.W283L | Q9NZN1 | protein_coding | deleterious(0.02) | probably_damaging(1) | TCGA-A2-A04R-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | taxol | SD | |
IL1RAPL1 | SNV | Missense_Mutation | c.28C>G | p.Leu10Val | p.L10V | Q9NZN1 | protein_coding | tolerated(0.21) | benign(0.003) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD | |
IL1RAPL1 | SNV | Missense_Mutation | rs766627012 | c.316C>T | p.Arg106Trp | p.R106W | Q9NZN1 | protein_coding | tolerated(0.16) | probably_damaging(0.983) | TCGA-A2-A04W-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | SD |
IL1RAPL1 | SNV | Missense_Mutation | c.1055N>T | p.Arg352Leu | p.R352L | Q9NZN1 | protein_coding | deleterious(0.04) | benign(0.341) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IL1RAPL1 | SNV | Missense_Mutation | c.1315N>A | p.Glu439Lys | p.E439K | Q9NZN1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
IL1RAPL1 | SNV | Missense_Mutation | c.97N>A | p.Asp33Asn | p.D33N | Q9NZN1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AO-A03L-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cyclophosphamide | SD | |
IL1RAPL1 | SNV | Missense_Mutation | c.601C>G | p.Leu201Val | p.L201V | Q9NZN1 | protein_coding | tolerated(0.11) | possibly_damaging(0.721) | TCGA-C8-A27B-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
IL1RAPL1 | SNV | Missense_Mutation | rs778199033 | c.349G>A | p.Ala117Thr | p.A117T | Q9NZN1 | protein_coding | tolerated(1) | benign(0.009) | TCGA-E9-A1ND-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | aromasin | SD |
IL1RAPL1 | SNV | Missense_Mutation | novel | c.514N>G | p.Leu172Val | p.L172V | Q9NZN1 | protein_coding | deleterious(0.03) | benign(0.012) | TCGA-E9-A5FL-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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