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Gene: IGF2BP3 |
Gene summary for IGF2BP3 |
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Gene information | Species | Human | Gene symbol | IGF2BP3 | Gene ID | 10643 |
Gene name | insulin like growth factor 2 mRNA binding protein 3 | |
Gene Alias | CT98 | |
Cytomap | 7p15.3 | |
Gene Type | protein-coding | GO ID | GO:0001816 | UniProtAcc | O00425 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10643 | IGF2BP3 | P27T-E | Human | Esophagus | ESCC | 9.78e-30 | 6.04e-01 | 0.1055 |
10643 | IGF2BP3 | P28T-E | Human | Esophagus | ESCC | 3.14e-50 | 8.57e-01 | 0.1149 |
10643 | IGF2BP3 | P32T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.15e-01 | 0.1666 |
10643 | IGF2BP3 | P36T-E | Human | Esophagus | ESCC | 5.72e-04 | 1.39e-01 | 0.1187 |
10643 | IGF2BP3 | P37T-E | Human | Esophagus | ESCC | 1.03e-11 | 2.56e-01 | 0.1371 |
10643 | IGF2BP3 | P38T-E | Human | Esophagus | ESCC | 1.93e-04 | 2.20e-01 | 0.127 |
10643 | IGF2BP3 | P39T-E | Human | Esophagus | ESCC | 5.88e-35 | 5.97e-01 | 0.0894 |
10643 | IGF2BP3 | P40T-E | Human | Esophagus | ESCC | 3.86e-11 | 3.80e-01 | 0.109 |
10643 | IGF2BP3 | P42T-E | Human | Esophagus | ESCC | 9.54e-22 | 5.88e-01 | 0.1175 |
10643 | IGF2BP3 | P47T-E | Human | Esophagus | ESCC | 9.56e-08 | 1.77e-01 | 0.1067 |
10643 | IGF2BP3 | P48T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.83e-01 | 0.0959 |
10643 | IGF2BP3 | P49T-E | Human | Esophagus | ESCC | 4.64e-06 | 5.72e-01 | 0.1768 |
10643 | IGF2BP3 | P52T-E | Human | Esophagus | ESCC | 8.84e-36 | 7.16e-01 | 0.1555 |
10643 | IGF2BP3 | P54T-E | Human | Esophagus | ESCC | 1.16e-21 | 4.99e-01 | 0.0975 |
10643 | IGF2BP3 | P61T-E | Human | Esophagus | ESCC | 8.11e-12 | 2.96e-01 | 0.099 |
10643 | IGF2BP3 | P62T-E | Human | Esophagus | ESCC | 2.29e-08 | 1.82e-01 | 0.1302 |
10643 | IGF2BP3 | P74T-E | Human | Esophagus | ESCC | 1.34e-11 | 3.84e-01 | 0.1479 |
10643 | IGF2BP3 | P75T-E | Human | Esophagus | ESCC | 4.09e-46 | 7.70e-01 | 0.1125 |
10643 | IGF2BP3 | P76T-E | Human | Esophagus | ESCC | 9.53e-09 | 1.70e-01 | 0.1207 |
10643 | IGF2BP3 | P79T-E | Human | Esophagus | ESCC | 2.27e-21 | 3.88e-01 | 0.1154 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:000641716 | Endometrium | AEH | regulation of translation | 94/2100 | 468/18723 | 1.14e-08 | 7.62e-07 | 94 |
GO:000640314 | Endometrium | AEH | RNA localization | 51/2100 | 201/18723 | 1.39e-08 | 8.98e-07 | 51 |
GO:00506579 | Endometrium | AEH | nucleic acid transport | 37/2100 | 163/18723 | 2.04e-05 | 4.09e-04 | 37 |
GO:00506589 | Endometrium | AEH | RNA transport | 37/2100 | 163/18723 | 2.04e-05 | 4.09e-04 | 37 |
GO:00512369 | Endometrium | AEH | establishment of RNA localization | 37/2100 | 166/18723 | 3.13e-05 | 5.66e-04 | 37 |
GO:00159319 | Endometrium | AEH | nucleobase-containing compound transport | 44/2100 | 222/18723 | 1.19e-04 | 1.66e-03 | 44 |
GO:00510285 | Endometrium | AEH | mRNA transport | 28/2100 | 130/18723 | 4.94e-04 | 5.06e-03 | 28 |
GO:0006403110 | Esophagus | ESCC | RNA localization | 166/8552 | 201/18723 | 1.95e-27 | 6.18e-25 | 166 |
GO:005123617 | Esophagus | ESCC | establishment of RNA localization | 134/8552 | 166/18723 | 1.23e-20 | 1.81e-18 | 134 |
GO:005102815 | Esophagus | ESCC | mRNA transport | 110/8552 | 130/18723 | 2.76e-20 | 3.80e-18 | 110 |
GO:005065717 | Esophagus | ESCC | nucleic acid transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:005065817 | Esophagus | ESCC | RNA transport | 131/8552 | 163/18723 | 6.94e-20 | 8.46e-18 | 131 |
GO:0006417111 | Esophagus | ESCC | regulation of translation | 304/8552 | 468/18723 | 1.53e-17 | 1.33e-15 | 304 |
GO:001593117 | Esophagus | ESCC | nucleobase-containing compound transport | 162/8552 | 222/18723 | 9.87e-17 | 7.93e-15 | 162 |
GO:003424914 | Esophagus | ESCC | negative regulation of cellular amide metabolic process | 144/8552 | 273/18723 | 1.08e-02 | 3.67e-02 | 144 |
GO:000640321 | Liver | HCC | RNA localization | 151/7958 | 201/18723 | 3.72e-21 | 5.89e-19 | 151 |
GO:000641722 | Liver | HCC | regulation of translation | 287/7958 | 468/18723 | 8.79e-17 | 8.08e-15 | 287 |
GO:005123621 | Liver | HCC | establishment of RNA localization | 121/7958 | 166/18723 | 1.61e-15 | 1.19e-13 | 121 |
GO:005065711 | Liver | HCC | nucleic acid transport | 118/7958 | 163/18723 | 8.30e-15 | 5.60e-13 | 118 |
GO:005065811 | Liver | HCC | RNA transport | 118/7958 | 163/18723 | 8.30e-15 | 5.60e-13 | 118 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
IGF2BP3 | SNV | Missense_Mutation | rs141308145 | c.1732N>T | p.Arg578Trp | p.R578W | O00425 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD |
IGF2BP3 | SNV | Missense_Mutation | novel | c.1325C>T | p.Ala442Val | p.A442V | O00425 | protein_coding | deleterious(0.05) | probably_damaging(0.915) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
IGF2BP3 | SNV | Missense_Mutation | c.1487C>G | p.Ser496Cys | p.S496C | O00425 | protein_coding | deleterious(0) | probably_damaging(0.964) | TCGA-C5-A1MH-01 | Cervix | cervical & endocervical cancer | Female | >=65 | III/IV | Chemotherapy | cisplatin | PD | |
IGF2BP3 | SNV | Missense_Mutation | novel | c.161N>C | p.Ile54Thr | p.I54T | O00425 | protein_coding | deleterious(0) | benign(0.124) | TCGA-C5-A8YQ-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
IGF2BP3 | SNV | Missense_Mutation | c.868C>T | p.Arg290Cys | p.R290C | O00425 | protein_coding | deleterious(0) | possibly_damaging(0.665) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
IGF2BP3 | SNV | Missense_Mutation | c.1406G>T | p.Arg469Ile | p.R469I | O00425 | protein_coding | deleterious(0.02) | possibly_damaging(0.881) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
IGF2BP3 | SNV | Missense_Mutation | novel | c.1381G>A | p.Glu461Lys | p.E461K | O00425 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-MA-AA43-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD |
IGF2BP3 | SNV | Missense_Mutation | c.184N>A | p.Glu62Lys | p.E62K | O00425 | protein_coding | tolerated(0.06) | benign(0.377) | TCGA-AA-3684-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
IGF2BP3 | SNV | Missense_Mutation | c.719N>A | p.Ala240Asp | p.A240D | O00425 | protein_coding | deleterious(0.01) | benign(0.292) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
IGF2BP3 | SNV | Missense_Mutation | c.672N>T | p.Gln224His | p.Q224H | O00425 | protein_coding | deleterious(0.02) | probably_damaging(0.99) | TCGA-AA-A024-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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