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Gene: HSPA2 |
Gene summary for HSPA2 |
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Gene information | Species | Human | Gene symbol | HSPA2 | Gene ID | 3306 |
Gene name | heat shock protein family A (Hsp70) member 2 | |
Gene Alias | HSP70-2 | |
Cytomap | 14q23.3 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A0A024R6B5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3306 | HSPA2 | P12T-E | Human | Esophagus | ESCC | 1.78e-51 | 1.78e+00 | 0.1122 |
3306 | HSPA2 | P15T-E | Human | Esophagus | ESCC | 8.32e-23 | 8.96e-01 | 0.1149 |
3306 | HSPA2 | P17T-E | Human | Esophagus | ESCC | 5.07e-07 | 1.06e+00 | 0.1278 |
3306 | HSPA2 | P20T-E | Human | Esophagus | ESCC | 1.42e-34 | 1.05e+00 | 0.1124 |
3306 | HSPA2 | P21T-E | Human | Esophagus | ESCC | 1.60e-38 | 1.43e+00 | 0.1617 |
3306 | HSPA2 | P22T-E | Human | Esophagus | ESCC | 3.88e-11 | 4.47e-01 | 0.1236 |
3306 | HSPA2 | P23T-E | Human | Esophagus | ESCC | 1.65e-06 | 7.10e-01 | 0.108 |
3306 | HSPA2 | P24T-E | Human | Esophagus | ESCC | 3.74e-07 | 5.64e-02 | 0.1287 |
3306 | HSPA2 | P26T-E | Human | Esophagus | ESCC | 3.91e-40 | 1.06e+00 | 0.1276 |
3306 | HSPA2 | P27T-E | Human | Esophagus | ESCC | 1.10e-77 | 2.68e+00 | 0.1055 |
3306 | HSPA2 | P28T-E | Human | Esophagus | ESCC | 5.38e-19 | 7.18e-01 | 0.1149 |
3306 | HSPA2 | P31T-E | Human | Esophagus | ESCC | 1.81e-63 | 1.58e+00 | 0.1251 |
3306 | HSPA2 | P32T-E | Human | Esophagus | ESCC | 7.66e-05 | 2.33e-01 | 0.1666 |
3306 | HSPA2 | P36T-E | Human | Esophagus | ESCC | 1.12e-16 | 1.16e+00 | 0.1187 |
3306 | HSPA2 | P37T-E | Human | Esophagus | ESCC | 1.29e-42 | 1.72e+00 | 0.1371 |
3306 | HSPA2 | P38T-E | Human | Esophagus | ESCC | 2.05e-04 | 5.66e-01 | 0.127 |
3306 | HSPA2 | P39T-E | Human | Esophagus | ESCC | 8.33e-08 | -7.27e-02 | 0.0894 |
3306 | HSPA2 | P40T-E | Human | Esophagus | ESCC | 2.60e-13 | 4.34e-02 | 0.109 |
3306 | HSPA2 | P42T-E | Human | Esophagus | ESCC | 2.11e-07 | 5.04e-01 | 0.1175 |
3306 | HSPA2 | P44T-E | Human | Esophagus | ESCC | 2.89e-06 | 7.37e-01 | 0.1096 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00447725 | Cervix | CC | mitotic cell cycle phase transition | 89/2311 | 424/18723 | 2.70e-07 | 1.12e-05 | 89 |
GO:00420269 | Cervix | CC | protein refolding | 12/2311 | 23/18723 | 4.41e-06 | 1.12e-04 | 12 |
GO:000698610 | Cervix | CC | response to unfolded protein | 36/2311 | 137/18723 | 6.83e-06 | 1.63e-04 | 36 |
GO:00457876 | Cervix | CC | positive regulation of cell cycle | 66/2311 | 313/18723 | 7.78e-06 | 1.81e-04 | 66 |
GO:00073466 | Cervix | CC | regulation of mitotic cell cycle | 88/2311 | 457/18723 | 1.26e-05 | 2.60e-04 | 88 |
GO:19019903 | Cervix | CC | regulation of mitotic cell cycle phase transition | 63/2311 | 299/18723 | 1.27e-05 | 2.60e-04 | 63 |
GO:003596610 | Cervix | CC | response to topologically incorrect protein | 39/2311 | 159/18723 | 1.68e-05 | 3.22e-04 | 39 |
GO:00459316 | Cervix | CC | positive regulation of mitotic cell cycle | 32/2311 | 121/18723 | 1.88e-05 | 3.47e-04 | 32 |
GO:003462010 | Cervix | CC | cellular response to unfolded protein | 27/2311 | 96/18723 | 2.53e-05 | 4.29e-04 | 27 |
GO:00610779 | Cervix | CC | chaperone-mediated protein folding | 21/2311 | 67/18723 | 3.40e-05 | 5.55e-04 | 21 |
GO:19019922 | Cervix | CC | positive regulation of mitotic cell cycle phase transition | 26/2311 | 93/18723 | 3.97e-05 | 6.18e-04 | 26 |
GO:002241110 | Cervix | CC | cellular component disassembly | 83/2311 | 443/18723 | 6.04e-05 | 8.68e-04 | 83 |
GO:00900685 | Cervix | CC | positive regulation of cell cycle process | 50/2311 | 236/18723 | 8.25e-05 | 1.11e-03 | 50 |
GO:19019873 | Cervix | CC | regulation of cell cycle phase transition | 74/2311 | 390/18723 | 9.80e-05 | 1.27e-03 | 74 |
GO:003596710 | Cervix | CC | cellular response to topologically incorrect protein | 29/2311 | 116/18723 | 1.35e-04 | 1.66e-03 | 29 |
GO:19019892 | Cervix | CC | positive regulation of cell cycle phase transition | 28/2311 | 115/18723 | 2.82e-04 | 3.07e-03 | 28 |
GO:00094089 | Cervix | CC | response to heat | 27/2311 | 110/18723 | 3.12e-04 | 3.32e-03 | 27 |
GO:00064579 | Cervix | CC | protein folding | 44/2311 | 212/18723 | 3.43e-04 | 3.59e-03 | 44 |
GO:00064589 | Cervix | CC | 'de novo' protein folding | 14/2311 | 43/18723 | 4.37e-04 | 4.38e-03 | 14 |
GO:00510859 | Cervix | CC | chaperone cofactor-dependent protein refolding | 12/2311 | 34/18723 | 4.85e-04 | 4.75e-03 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0502018 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa0461220 | Cervix | CC | Antigen processing and presentation | 34/1267 | 78/8465 | 1.06e-09 | 2.14e-08 | 1.26e-08 | 34 |
hsa0541720 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa0414120 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa0491520 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0414418 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0514514 | Cervix | CC | Toxoplasmosis | 34/1267 | 112/8465 | 2.42e-05 | 1.82e-04 | 1.08e-04 | 34 |
hsa0513416 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa040109 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0502019 | Cervix | CC | Prion disease | 98/1267 | 273/8465 | 2.64e-18 | 1.42e-16 | 8.42e-17 | 98 |
hsa04612110 | Cervix | CC | Antigen processing and presentation | 34/1267 | 78/8465 | 1.06e-09 | 2.14e-08 | 1.26e-08 | 34 |
hsa05417110 | Cervix | CC | Lipid and atherosclerosis | 65/1267 | 215/8465 | 6.47e-09 | 1.10e-07 | 6.52e-08 | 65 |
hsa04141110 | Cervix | CC | Protein processing in endoplasmic reticulum | 55/1267 | 174/8465 | 1.74e-08 | 2.68e-07 | 1.58e-07 | 55 |
hsa04915110 | Cervix | CC | Estrogen signaling pathway | 44/1267 | 138/8465 | 3.55e-07 | 3.97e-06 | 2.35e-06 | 44 |
hsa0414419 | Cervix | CC | Endocytosis | 64/1267 | 251/8465 | 6.97e-06 | 6.10e-05 | 3.61e-05 | 64 |
hsa0514515 | Cervix | CC | Toxoplasmosis | 34/1267 | 112/8465 | 2.42e-05 | 1.82e-04 | 1.08e-04 | 34 |
hsa0513417 | Cervix | CC | Legionellosis | 20/1267 | 57/8465 | 1.29e-04 | 8.19e-04 | 4.85e-04 | 20 |
hsa0401012 | Cervix | CC | MAPK signaling pathway | 62/1267 | 302/8465 | 4.89e-03 | 1.67e-02 | 9.86e-03 | 62 |
hsa0502030 | Esophagus | HGIN | Prion disease | 117/1383 | 273/8465 | 4.15e-26 | 3.38e-24 | 2.69e-24 | 117 |
hsa0304018 | Esophagus | HGIN | Spliceosome | 79/1383 | 217/8465 | 3.22e-13 | 7.00e-12 | 5.56e-12 | 79 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSPA2 | SNV | Missense_Mutation | c.53N>A | p.Cys18Tyr | p.C18Y | P54652 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.984) | TCGA-A2-A0YJ-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | PD | |
HSPA2 | SNV | Missense_Mutation | c.500N>A | p.Gly167Glu | p.G167E | P54652 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-A8-A092-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | CR | |
HSPA2 | SNV | Missense_Mutation | c.916G>A | p.Glu306Lys | p.E306K | P54652 | protein_coding | deleterious_low_confidence(0) | probably_damaging(1) | TCGA-A8-A095-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
HSPA2 | SNV | Missense_Mutation | c.1782N>T | p.Glu594Asp | p.E594D | P54652 | protein_coding | deleterious_low_confidence(0.02) | benign(0.327) | TCGA-B6-A0IH-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
HSPA2 | SNV | Missense_Mutation | c.905G>A | p.Arg302His | p.R302H | P54652 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(1) | TCGA-D8-A1J8-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | nolvadex | SD | |
HSPA2 | SNV | Missense_Mutation | c.1192G>A | p.Asp398Asn | p.D398N | P54652 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.96) | TCGA-D8-A1JP-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | tamoxiphen | SD | |
HSPA2 | insertion | In_Frame_Ins | novel | c.1386_1387insCCCAAGATCCAGAAGCTGCTGCAG | p.Phe462_Asp463insProLysIleGlnLysLeuLeuGln | p.F462_D463insPKIQKLLQ | P54652 | protein_coding | TCGA-A2-A0T2-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | xeloda | PD | ||
HSPA2 | insertion | In_Frame_Ins | novel | c.1717_1718insTCTTCTTCCCAGAGGAGATATCCTCCATGG | p.Ile573_Leu574insPhePheProGluGluIleSerSerMetVal | p.I573_L574insFFPEEISSMV | P54652 | protein_coding | TCGA-A8-A09C-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HSPA2 | SNV | Missense_Mutation | c.514C>A | p.Arg172Ser | p.R172S | P54652 | protein_coding | deleterious_low_confidence(0.01) | benign(0.241) | TCGA-FU-A3EO-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HSPA2 | SNV | Missense_Mutation | rs765920858 | c.1771G>A | p.Glu591Lys | p.E591K | P54652 | protein_coding | deleterious_low_confidence(0.01) | benign(0.192) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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