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Gene: HSD3B7 |
Gene summary for HSD3B7 |
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Gene information | Species | Human | Gene symbol | HSD3B7 | Gene ID | 80270 |
Gene name | hydroxy-delta-5-steroid dehydrogenase, 3 beta- and steroid delta-isomerase 7 | |
Gene Alias | CBAS1 | |
Cytomap | 16p11.2 | |
Gene Type | protein-coding | GO ID | GO:0002376 | UniProtAcc | Q9H2F3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
80270 | HSD3B7 | P38T-E | Human | Esophagus | ESCC | 6.46e-05 | 2.21e-01 | 0.127 |
80270 | HSD3B7 | P39T-E | Human | Esophagus | ESCC | 4.35e-04 | 6.13e-02 | 0.0894 |
80270 | HSD3B7 | P40T-E | Human | Esophagus | ESCC | 4.30e-06 | 1.89e-01 | 0.109 |
80270 | HSD3B7 | P42T-E | Human | Esophagus | ESCC | 2.54e-04 | 1.21e-01 | 0.1175 |
80270 | HSD3B7 | P47T-E | Human | Esophagus | ESCC | 1.72e-05 | 7.84e-02 | 0.1067 |
80270 | HSD3B7 | P48T-E | Human | Esophagus | ESCC | 7.80e-04 | 1.02e-01 | 0.0959 |
80270 | HSD3B7 | P49T-E | Human | Esophagus | ESCC | 1.61e-02 | 2.03e-01 | 0.1768 |
80270 | HSD3B7 | P52T-E | Human | Esophagus | ESCC | 9.85e-10 | 2.86e-01 | 0.1555 |
80270 | HSD3B7 | P54T-E | Human | Esophagus | ESCC | 3.82e-11 | 2.16e-01 | 0.0975 |
80270 | HSD3B7 | P57T-E | Human | Esophagus | ESCC | 1.81e-07 | 2.36e-01 | 0.0926 |
80270 | HSD3B7 | P61T-E | Human | Esophagus | ESCC | 2.08e-09 | 2.46e-01 | 0.099 |
80270 | HSD3B7 | P62T-E | Human | Esophagus | ESCC | 1.14e-09 | 1.68e-01 | 0.1302 |
80270 | HSD3B7 | P65T-E | Human | Esophagus | ESCC | 2.72e-11 | 2.68e-01 | 0.0978 |
80270 | HSD3B7 | P74T-E | Human | Esophagus | ESCC | 1.74e-10 | 3.35e-01 | 0.1479 |
80270 | HSD3B7 | P75T-E | Human | Esophagus | ESCC | 8.02e-12 | 2.05e-01 | 0.1125 |
80270 | HSD3B7 | P76T-E | Human | Esophagus | ESCC | 7.92e-07 | 1.76e-01 | 0.1207 |
80270 | HSD3B7 | P80T-E | Human | Esophagus | ESCC | 8.76e-15 | 4.86e-01 | 0.155 |
80270 | HSD3B7 | P82T-E | Human | Esophagus | ESCC | 7.57e-10 | 6.78e-01 | 0.1072 |
80270 | HSD3B7 | P83T-E | Human | Esophagus | ESCC | 4.96e-09 | 1.52e-01 | 0.1738 |
80270 | HSD3B7 | P84T-E | Human | Esophagus | ESCC | 1.59e-02 | 1.62e-01 | 0.0933 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00463948 | Esophagus | ESCC | carboxylic acid biosynthetic process | 175/8552 | 314/18723 | 1.98e-04 | 1.26e-03 | 175 |
GO:00160538 | Esophagus | ESCC | organic acid biosynthetic process | 175/8552 | 316/18723 | 3.04e-04 | 1.82e-03 | 175 |
GO:00066946 | Esophagus | ESCC | steroid biosynthetic process | 98/8552 | 173/18723 | 2.34e-03 | 1.03e-02 | 98 |
GO:19016174 | Esophagus | ESCC | organic hydroxy compound biosynthetic process | 128/8552 | 237/18723 | 5.86e-03 | 2.16e-02 | 128 |
GO:000820211 | Liver | Cirrhotic | steroid metabolic process | 143/4634 | 319/18723 | 2.79e-15 | 3.18e-13 | 143 |
GO:001605312 | Liver | Cirrhotic | organic acid biosynthetic process | 139/4634 | 316/18723 | 4.28e-14 | 3.83e-12 | 139 |
GO:004639412 | Liver | Cirrhotic | carboxylic acid biosynthetic process | 137/4634 | 314/18723 | 1.40e-13 | 1.14e-11 | 137 |
GO:007233011 | Liver | Cirrhotic | monocarboxylic acid biosynthetic process | 93/4634 | 214/18723 | 1.43e-09 | 6.16e-08 | 93 |
GO:00066941 | Liver | Cirrhotic | steroid biosynthetic process | 77/4634 | 173/18723 | 1.02e-08 | 3.91e-07 | 77 |
GO:19016171 | Liver | Cirrhotic | organic hydroxy compound biosynthetic process | 81/4634 | 237/18723 | 6.73e-04 | 5.06e-03 | 81 |
GO:00082061 | Liver | Cirrhotic | bile acid metabolic process | 22/4634 | 49/18723 | 1.64e-03 | 1.05e-02 | 22 |
GO:00066991 | Liver | Cirrhotic | bile acid biosynthetic process | 17/4634 | 36/18723 | 2.82e-03 | 1.63e-02 | 17 |
GO:001605321 | Liver | HCC | organic acid biosynthetic process | 200/7958 | 316/18723 | 5.24e-14 | 3.22e-12 | 200 |
GO:004639421 | Liver | HCC | carboxylic acid biosynthetic process | 198/7958 | 314/18723 | 1.19e-13 | 6.78e-12 | 198 |
GO:00082022 | Liver | HCC | steroid metabolic process | 188/7958 | 319/18723 | 1.96e-09 | 5.63e-08 | 188 |
GO:007233021 | Liver | HCC | monocarboxylic acid biosynthetic process | 129/7958 | 214/18723 | 1.08e-07 | 2.09e-06 | 129 |
GO:00066942 | Liver | HCC | steroid biosynthetic process | 104/7958 | 173/18723 | 2.13e-06 | 2.91e-05 | 104 |
GO:00082062 | Liver | HCC | bile acid metabolic process | 34/7958 | 49/18723 | 1.28e-04 | 1.06e-03 | 34 |
GO:19016172 | Liver | HCC | organic hydroxy compound biosynthetic process | 129/7958 | 237/18723 | 1.32e-04 | 1.08e-03 | 129 |
GO:00066992 | Liver | HCC | bile acid biosynthetic process | 26/7958 | 36/18723 | 2.93e-04 | 2.10e-03 | 26 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa001202 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
hsa001203 | Liver | HCC | Primary bile acid biosynthesis | 14/4020 | 17/8465 | 3.49e-03 | 1.12e-02 | 6.22e-03 | 14 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HSD3B7 | SNV | Missense_Mutation | rs745605788 | c.80G>A | p.Arg27Gln | p.R27Q | Q9H2F3 | protein_coding | tolerated(0.11) | benign(0.313) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HSD3B7 | SNV | Missense_Mutation | novel | c.583T>C | p.Tyr195His | p.Y195H | Q9H2F3 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-C5-A8XK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
HSD3B7 | SNV | Missense_Mutation | c.587N>A | p.Gly196Asp | p.G196D | Q9H2F3 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-IR-A3LK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD | |
HSD3B7 | SNV | Missense_Mutation | c.496G>A | p.Ala166Thr | p.A166T | Q9H2F3 | protein_coding | deleterious(0) | probably_damaging(0.929) | TCGA-AA-3710-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HSD3B7 | SNV | Missense_Mutation | rs560826820 | c.499G>A | p.Glu167Lys | p.E167K | Q9H2F3 | protein_coding | deleterious(0) | possibly_damaging(0.725) | TCGA-AD-5900-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
HSD3B7 | SNV | Missense_Mutation | c.591A>C | p.Glu197Asp | p.E197D | Q9H2F3 | protein_coding | tolerated(0.05) | possibly_damaging(0.859) | TCGA-G4-6588-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HSD3B7 | SNV | Missense_Mutation | rs765855524 | c.1067G>A | p.Arg356His | p.R356H | Q9H2F3 | protein_coding | deleterious(0.03) | possibly_damaging(0.717) | TCGA-AP-A051-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HSD3B7 | SNV | Missense_Mutation | novel | c.24G>T | p.Gln8His | p.Q8H | Q9H2F3 | protein_coding | tolerated(0.09) | benign(0.087) | TCGA-AP-A1DV-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HSD3B7 | SNV | Missense_Mutation | rs779021008 | c.1018N>T | p.Arg340Cys | p.R340C | Q9H2F3 | protein_coding | deleterious(0) | possibly_damaging(0.886) | TCGA-AX-A06H-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | paclitaxel | SD |
HSD3B7 | SNV | Missense_Mutation | rs775593829 | c.968N>T | p.Thr323Met | p.T323M | Q9H2F3 | protein_coding | deleterious(0) | possibly_damaging(0.791) | TCGA-AX-A0J1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
80270 | HSD3B7 | ENZYME, DRUGGABLE GENOME | cholic acid |
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