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Gene: HOXA9 |
Gene summary for HOXA9 |
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Gene information | Species | Human | Gene symbol | HOXA9 | Gene ID | 3205 |
Gene name | homeobox A9 | |
Gene Alias | ABD-B | |
Cytomap | 7p15.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | P31269 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3205 | HOXA9 | P17T-E | Human | Esophagus | ESCC | 2.60e-06 | 3.54e-01 | 0.1278 |
3205 | HOXA9 | P19T-E | Human | Esophagus | ESCC | 7.48e-03 | 3.10e-01 | 0.1662 |
3205 | HOXA9 | P21T-E | Human | Esophagus | ESCC | 6.38e-31 | 5.98e-01 | 0.1617 |
3205 | HOXA9 | P22T-E | Human | Esophagus | ESCC | 1.62e-13 | 2.56e-01 | 0.1236 |
3205 | HOXA9 | P23T-E | Human | Esophagus | ESCC | 7.50e-13 | 3.45e-01 | 0.108 |
3205 | HOXA9 | P24T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.52e-01 | 0.1287 |
3205 | HOXA9 | P26T-E | Human | Esophagus | ESCC | 4.71e-53 | 8.95e-01 | 0.1276 |
3205 | HOXA9 | P32T-E | Human | Esophagus | ESCC | 9.44e-07 | 2.06e-01 | 0.1666 |
3205 | HOXA9 | P47T-E | Human | Esophagus | ESCC | 1.13e-16 | 2.96e-01 | 0.1067 |
3205 | HOXA9 | P48T-E | Human | Esophagus | ESCC | 1.66e-02 | 8.03e-02 | 0.0959 |
3205 | HOXA9 | P49T-E | Human | Esophagus | ESCC | 1.65e-10 | 5.93e-01 | 0.1768 |
3205 | HOXA9 | P54T-E | Human | Esophagus | ESCC | 1.11e-08 | 2.25e-01 | 0.0975 |
3205 | HOXA9 | P56T-E | Human | Esophagus | ESCC | 5.84e-10 | 1.02e+00 | 0.1613 |
3205 | HOXA9 | P57T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.53e-02 | 0.0926 |
3205 | HOXA9 | P65T-E | Human | Esophagus | ESCC | 6.40e-20 | 3.77e-01 | 0.0978 |
3205 | HOXA9 | P74T-E | Human | Esophagus | ESCC | 7.24e-03 | 1.25e-01 | 0.1479 |
3205 | HOXA9 | P76T-E | Human | Esophagus | ESCC | 4.16e-22 | 4.92e-01 | 0.1207 |
3205 | HOXA9 | P79T-E | Human | Esophagus | ESCC | 4.24e-18 | 3.46e-01 | 0.1154 |
3205 | HOXA9 | P82T-E | Human | Esophagus | ESCC | 1.98e-12 | 5.43e-01 | 0.1072 |
3205 | HOXA9 | P89T-E | Human | Esophagus | ESCC | 4.62e-24 | 1.47e+00 | 0.1752 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0048732 | Colorectum | AD | gland development | 149/3918 | 436/18723 | 6.07e-11 | 6.33e-09 | 149 |
GO:0030099 | Colorectum | AD | myeloid cell differentiation | 119/3918 | 381/18723 | 1.24e-06 | 4.01e-05 | 119 |
GO:0030879 | Colorectum | AD | mammary gland development | 53/3918 | 137/18723 | 1.46e-06 | 4.58e-05 | 53 |
GO:0061458 | Colorectum | AD | reproductive system development | 116/3918 | 427/18723 | 1.11e-03 | 1.01e-02 | 116 |
GO:0048608 | Colorectum | AD | reproductive structure development | 114/3918 | 424/18723 | 1.78e-03 | 1.47e-02 | 114 |
GO:1903706 | Colorectum | AD | regulation of hemopoiesis | 99/3918 | 367/18723 | 3.08e-03 | 2.28e-02 | 99 |
GO:0045637 | Colorectum | AD | regulation of myeloid cell differentiation | 61/3918 | 210/18723 | 3.17e-03 | 2.35e-02 | 61 |
GO:0048736 | Colorectum | AD | appendage development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0060173 | Colorectum | AD | limb development | 51/3918 | 172/18723 | 4.20e-03 | 2.89e-02 | 51 |
GO:0048568 | Colorectum | AD | embryonic organ development | 112/3918 | 427/18723 | 4.60e-03 | 3.14e-02 | 112 |
GO:00487322 | Colorectum | MSS | gland development | 143/3467 | 436/18723 | 3.85e-13 | 8.01e-11 | 143 |
GO:00308792 | Colorectum | MSS | mammary gland development | 51/3467 | 137/18723 | 1.88e-07 | 8.26e-06 | 51 |
GO:00300992 | Colorectum | MSS | myeloid cell differentiation | 110/3467 | 381/18723 | 4.48e-07 | 1.75e-05 | 110 |
GO:00614582 | Colorectum | MSS | reproductive system development | 115/3467 | 427/18723 | 9.86e-06 | 2.39e-04 | 115 |
GO:00486082 | Colorectum | MSS | reproductive structure development | 113/3467 | 424/18723 | 1.94e-05 | 4.18e-04 | 113 |
GO:00487362 | Colorectum | MSS | appendage development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:00601732 | Colorectum | MSS | limb development | 48/3467 | 172/18723 | 1.61e-03 | 1.46e-02 | 48 |
GO:19037061 | Colorectum | MSS | regulation of hemopoiesis | 89/3467 | 367/18723 | 3.39e-03 | 2.56e-02 | 89 |
GO:00456371 | Colorectum | MSS | regulation of myeloid cell differentiation | 54/3467 | 210/18723 | 5.85e-03 | 3.96e-02 | 54 |
GO:00485681 | Colorectum | MSS | embryonic organ development | 100/3467 | 427/18723 | 6.00e-03 | 4.03e-02 | 100 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa05202 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052021 | Colorectum | FAP | Transcriptional misregulation in cancer | 45/1404 | 193/8465 | 9.19e-03 | 3.33e-02 | 2.03e-02 | 45 |
hsa052028 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
hsa0520213 | Esophagus | ESCC | Transcriptional misregulation in cancer | 116/4205 | 193/8465 | 2.08e-03 | 5.95e-03 | 3.05e-03 | 116 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
HOXA9 | LUM | Endometrium | Healthy | PGRMC1,HOXA11,CHST7, etc. | 3.94e-01 | ![]() |
HOXA9 | BAS | Endometrium | Healthy | PGRMC1,HOXA11,CHST7, etc. | 2.83e-01 | ![]() |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HOXA9 | SNV | Missense_Mutation | novel | c.520G>A | p.Ala174Thr | p.A174T | P31269 | protein_coding | tolerated(0.29) | benign(0.066) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
HOXA9 | SNV | Missense_Mutation | c.770G>A | p.Arg257His | p.R257H | P31269 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
HOXA9 | SNV | Missense_Mutation | rs267601472 | c.620G>A | p.Arg207Gln | p.R207Q | P31269 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HOXA9 | SNV | Missense_Mutation | c.792N>G | p.Ile264Met | p.I264M | P31269 | protein_coding | tolerated(1) | benign(0.01) | TCGA-VS-A9UQ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | PD | |
HOXA9 | SNV | Missense_Mutation | c.326G>A | p.Arg109His | p.R109H | P31269 | protein_coding | deleterious(0.02) | possibly_damaging(0.866) | TCGA-A6-2681-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HOXA9 | SNV | Missense_Mutation | rs369971422 | c.500A>G | p.Glu167Gly | p.E167G | P31269 | protein_coding | tolerated(0.24) | benign(0.007) | TCGA-AD-6889-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | xeloda | PD |
HOXA9 | SNV | Missense_Mutation | novel | c.628C>T | p.Arg210Trp | p.R210W | P31269 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
HOXA9 | SNV | Missense_Mutation | c.770N>T | p.Arg257Leu | p.R257L | P31269 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HOXA9 | SNV | Missense_Mutation | c.608C>T | p.Ala203Val | p.A203V | P31269 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AX-A0J0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HOXA9 | SNV | Missense_Mutation | c.688N>C | p.Tyr230His | p.Y230H | P31269 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-BG-A0LX-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
3205 | HOXA9 | TRANSCRIPTION FACTOR, CLINICALLY ACTIONABLE | G-CSF | FILGRASTIM | 11687616 |
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