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Gene: HNRNPAB |
Gene summary for HNRNPAB |
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Gene information | Species | Human | Gene symbol | HNRNPAB | Gene ID | 3182 |
Gene name | heterogeneous nuclear ribonucleoprotein A/B | |
Gene Alias | ABBP1 | |
Cytomap | 5q35.3 | |
Gene Type | protein-coding | GO ID | GO:0001837 | UniProtAcc | Q99729 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
3182 | HNRNPAB | NCCBC5 | Human | Breast | DCIS | 2.66e-11 | 1.48e-01 | 0.2046 |
3182 | HNRNPAB | NCCBC6 | Human | Breast | DCIS | 1.09e-05 | 5.18e-01 | 0.2095 |
3182 | HNRNPAB | P1 | Human | Breast | IDC | 2.75e-13 | 4.32e-02 | 0.1527 |
3182 | HNRNPAB | P2 | Human | Breast | IDC | 8.55e-05 | 2.97e-01 | 0.21 |
3182 | HNRNPAB | DCIS2 | Human | Breast | DCIS | 5.82e-52 | 4.28e-01 | 0.0085 |
3182 | HNRNPAB | CA_HPV_1 | Human | Cervix | CC | 5.23e-06 | 2.14e-02 | 0.0264 |
3182 | HNRNPAB | N_HPV_2 | Human | Cervix | N_HPV | 1.27e-02 | 2.46e-01 | -0.0131 |
3182 | HNRNPAB | CCI_1 | Human | Cervix | CC | 4.09e-03 | -5.35e-01 | 0.528 |
3182 | HNRNPAB | CCII_1 | Human | Cervix | CC | 6.15e-10 | -5.70e-01 | 0.3249 |
3182 | HNRNPAB | sample1 | Human | Cervix | CC | 1.97e-02 | 3.87e-01 | 0.0959 |
3182 | HNRNPAB | sample3 | Human | Cervix | CC | 1.69e-03 | -2.40e-01 | 0.1387 |
3182 | HNRNPAB | L1 | Human | Cervix | CC | 3.78e-02 | -3.41e-01 | 0.0802 |
3182 | HNRNPAB | T1 | Human | Cervix | CC | 1.26e-10 | 4.55e-01 | 0.0918 |
3182 | HNRNPAB | T3 | Human | Cervix | CC | 1.97e-02 | -2.49e-01 | 0.1389 |
3182 | HNRNPAB | HTA11_1938_2000001011 | Human | Colorectum | AD | 2.46e-03 | 4.40e-01 | -0.0811 |
3182 | HNRNPAB | HTA11_78_2000001011 | Human | Colorectum | AD | 1.76e-02 | 4.68e-01 | -0.1088 |
3182 | HNRNPAB | HTA11_347_2000001011 | Human | Colorectum | AD | 2.45e-16 | 6.09e-01 | -0.1954 |
3182 | HNRNPAB | HTA11_3361_2000001011 | Human | Colorectum | AD | 1.93e-02 | 5.21e-01 | -0.1207 |
3182 | HNRNPAB | HTA11_83_2000001011 | Human | Colorectum | SER | 1.38e-03 | 4.92e-01 | -0.1526 |
3182 | HNRNPAB | HTA11_696_2000001011 | Human | Colorectum | AD | 2.09e-08 | 4.51e-01 | -0.1464 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00018373 | Breast | Precancer | epithelial to mesenchymal transition | 19/1080 | 157/18723 | 1.78e-03 | 1.75e-02 | 19 |
GO:000183711 | Breast | IDC | epithelial to mesenchymal transition | 23/1434 | 157/18723 | 1.97e-03 | 1.88e-02 | 23 |
GO:000183721 | Breast | DCIS | epithelial to mesenchymal transition | 22/1390 | 157/18723 | 2.92e-03 | 2.50e-02 | 22 |
GO:00018374 | Cervix | CC | epithelial to mesenchymal transition | 31/2311 | 157/18723 | 5.25e-03 | 3.08e-02 | 31 |
GO:00487624 | Cervix | CC | mesenchymal cell differentiation | 42/2311 | 236/18723 | 9.12e-03 | 4.60e-02 | 42 |
GO:0048762 | Colorectum | MSS | mesenchymal cell differentiation | 59/3467 | 236/18723 | 7.79e-03 | 4.84e-02 | 59 |
GO:00487621 | Colorectum | FAP | mesenchymal cell differentiation | 52/2622 | 236/18723 | 5.08e-04 | 5.80e-03 | 52 |
GO:0001837 | Colorectum | FAP | epithelial to mesenchymal transition | 36/2622 | 157/18723 | 1.67e-03 | 1.47e-02 | 36 |
GO:0060485 | Colorectum | FAP | mesenchyme development | 59/2622 | 291/18723 | 1.94e-03 | 1.64e-02 | 59 |
GO:00487625 | Endometrium | AEH | mesenchymal cell differentiation | 46/2100 | 236/18723 | 1.27e-04 | 1.74e-03 | 46 |
GO:00604853 | Endometrium | AEH | mesenchyme development | 54/2100 | 291/18723 | 1.34e-04 | 1.83e-03 | 54 |
GO:00018375 | Endometrium | AEH | epithelial to mesenchymal transition | 33/2100 | 157/18723 | 2.64e-04 | 3.09e-03 | 33 |
GO:004876212 | Endometrium | EEC | mesenchymal cell differentiation | 47/2168 | 236/18723 | 1.35e-04 | 1.76e-03 | 47 |
GO:006048512 | Endometrium | EEC | mesenchyme development | 54/2168 | 291/18723 | 3.01e-04 | 3.37e-03 | 54 |
GO:000183712 | Endometrium | EEC | epithelial to mesenchymal transition | 33/2168 | 157/18723 | 4.71e-04 | 4.84e-03 | 33 |
GO:00018378 | Esophagus | ESCC | epithelial to mesenchymal transition | 95/8552 | 157/18723 | 1.25e-04 | 8.56e-04 | 95 |
GO:00487628 | Esophagus | ESCC | mesenchymal cell differentiation | 133/8552 | 236/18723 | 5.94e-04 | 3.22e-03 | 133 |
GO:00604856 | Esophagus | ESCC | mesenchyme development | 156/8552 | 291/18723 | 3.76e-03 | 1.53e-02 | 156 |
GO:00018377 | Oral cavity | OSCC | epithelial to mesenchymal transition | 82/7305 | 157/18723 | 5.09e-04 | 2.98e-03 | 82 |
GO:00487627 | Oral cavity | OSCC | mesenchymal cell differentiation | 109/7305 | 236/18723 | 1.43e-02 | 4.69e-02 | 109 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HNRNPAB | SNV | Missense_Mutation | rs377150533 | c.859G>A | p.Gly287Arg | p.G287R | Q99729 | protein_coding | tolerated(0.17) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
HNRNPAB | SNV | Missense_Mutation | c.380T>C | p.Val127Ala | p.V127A | Q99729 | protein_coding | deleterious(0.05) | probably_damaging(0.95) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |
HNRNPAB | SNV | Missense_Mutation | c.447N>T | p.Lys149Asn | p.K149N | Q99729 | protein_coding | deleterious(0.04) | probably_damaging(0.974) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
HNRNPAB | SNV | Missense_Mutation | rs528992480 | c.922G>A | p.Asp308Asn | p.D308N | Q99729 | protein_coding | tolerated(0.14) | benign(0.025) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
HNRNPAB | insertion | Frame_Shift_Ins | novel | c.644_645insTAAGCCCT | p.Lys215AsnfsTer130 | p.K215Nfs*130 | Q99729 | protein_coding | TCGA-AM-5820-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
HNRNPAB | insertion | Frame_Shift_Ins | novel | c.426_427insA | p.Ala145GlyfsTer20 | p.A145Gfs*20 | Q99729 | protein_coding | TCGA-QG-A5YV-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | xeloda | CR | ||
HNRNPAB | insertion | Frame_Shift_Ins | novel | c.978_979insA | p.Asn327LysfsTer2 | p.N327Kfs*2 | Q99729 | protein_coding | TCGA-DC-6160-01 | Colorectum | rectum adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | ||
HNRNPAB | deletion | In_Frame_Del | c.389_391delNNN | p.Lys131del | p.K131del | Q99729 | protein_coding | TCGA-EI-6507-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD | |||
HNRNPAB | deletion | Frame_Shift_Del | c.606delT | p.Phe202LeufsTer7 | p.F202Lfs*7 | Q99729 | protein_coding | TCGA-F5-6864-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |||
HNRNPAB | SNV | Missense_Mutation | rs750746697 | c.547A>G | p.Ile183Val | p.I183V | Q99729 | protein_coding | tolerated(0.08) | benign(0.279) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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