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Gene: HIST2H2BF |
Gene summary for HIST2H2BF |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HIST2H2BF | Gene ID | 440689 |
| Gene name | H2B clustered histone 18 | |
| Gene Alias | HIST2H2BF | |
| Cytomap | 1q21.2 | |
| Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | Q5QNW6 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 440689 | HIST2H2BF | P22T-E | Human | Esophagus | ESCC | 1.30e-15 | 3.41e-01 | 0.1236 |
| 440689 | HIST2H2BF | P23T-E | Human | Esophagus | ESCC | 7.31e-09 | 4.88e-01 | 0.108 |
| 440689 | HIST2H2BF | P24T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.76e-01 | 0.1287 |
| 440689 | HIST2H2BF | P26T-E | Human | Esophagus | ESCC | 1.78e-03 | 1.10e-01 | 0.1276 |
| 440689 | HIST2H2BF | P27T-E | Human | Esophagus | ESCC | 1.55e-07 | 2.72e-01 | 0.1055 |
| 440689 | HIST2H2BF | P28T-E | Human | Esophagus | ESCC | 3.50e-02 | 9.10e-02 | 0.1149 |
| 440689 | HIST2H2BF | P30T-E | Human | Esophagus | ESCC | 7.69e-05 | 1.38e-01 | 0.137 |
| 440689 | HIST2H2BF | P31T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.37e-01 | 0.1251 |
| 440689 | HIST2H2BF | P32T-E | Human | Esophagus | ESCC | 8.40e-04 | 1.22e-01 | 0.1666 |
| 440689 | HIST2H2BF | P36T-E | Human | Esophagus | ESCC | 9.21e-06 | 3.89e-01 | 0.1187 |
| 440689 | HIST2H2BF | P37T-E | Human | Esophagus | ESCC | 1.09e-04 | 1.15e-01 | 0.1371 |
| 440689 | HIST2H2BF | P39T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.71e-01 | 0.0894 |
| 440689 | HIST2H2BF | P42T-E | Human | Esophagus | ESCC | 2.64e-06 | 1.43e-01 | 0.1175 |
| 440689 | HIST2H2BF | P47T-E | Human | Esophagus | ESCC | 1.96e-05 | 1.30e-01 | 0.1067 |
| 440689 | HIST2H2BF | P48T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.48e-01 | 0.0959 |
| 440689 | HIST2H2BF | P49T-E | Human | Esophagus | ESCC | 4.65e-04 | 7.81e-01 | 0.1768 |
| 440689 | HIST2H2BF | P52T-E | Human | Esophagus | ESCC | 3.28e-14 | 2.77e-01 | 0.1555 |
| 440689 | HIST2H2BF | P54T-E | Human | Esophagus | ESCC | 6.29e-05 | 2.65e-01 | 0.0975 |
| 440689 | HIST2H2BF | P56T-E | Human | Esophagus | ESCC | 2.31e-02 | 4.06e-01 | 0.1613 |
| 440689 | HIST2H2BF | P57T-E | Human | Esophagus | ESCC | 9.20e-06 | 1.47e-01 | 0.0926 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Cervix |  | CC: Cervix cancer |
| HSIL_HPV: HPV-infected high-grade squamous intraepithelial lesions | ||
| N_HPV: HPV-infected normal cervix | ||
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HIST2H2BF | SNV | Missense_Mutation | c.210C>G | p.Ile70Met | p.I70M | Q5QNW6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.985) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HIST2H2BF | SNV | Missense_Mutation | c.295N>A | p.Val99Met | p.V99M | Q5QNW6 | protein_coding | tolerated_low_confidence(0.08) | benign(0.439) | TCGA-BH-A0H5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cytoxan | CR | |
| HIST2H2BF | SNV | Missense_Mutation | c.271A>G | p.Thr91Ala | p.T91A | Q5QNW6 | protein_coding | deleterious_low_confidence(0.03) | possibly_damaging(0.491) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
| HIST2H2BF | SNV | Missense_Mutation | c.251N>G | p.Tyr84Cys | p.Y84C | Q5QNW6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(1) | TCGA-A6-6653-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
| HIST2H2BF | SNV | Missense_Mutation | novel | c.25C>G | p.Pro9Ala | p.P9A | Q5QNW6 | protein_coding | tolerated_low_confidence(0.07) | benign(0.147) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
| HIST2H2BF | SNV | Missense_Mutation | c.146T>C | p.Val49Ala | p.V49A | Q5QNW6 | protein_coding | deleterious_low_confidence(0.01) | probably_damaging(0.999) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
| HIST2H2BF | SNV | Missense_Mutation | novel | c.356N>G | p.Val119Gly | p.V119G | Q5QNW6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.925) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD |
| HIST2H2BF | SNV | Missense_Mutation | c.131N>T | p.Lys44Met | p.K44M | Q5QNW6 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.982) | TCGA-AP-A1DP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | paclitaxel | PD | |
| HIST2H2BF | SNV | Missense_Mutation | rs782732328 | c.244G>A | p.Ala82Thr | p.A82T | Q5QNW6 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.984) | TCGA-B5-A11E-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HIST2H2BF | SNV | Missense_Mutation | novel | c.214G>A | p.Glu72Lys | p.E72K | Q5QNW6 | protein_coding | deleterious_low_confidence(0.04) | benign(0.115) | TCGA-DF-A2KZ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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