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Gene: HIST1H2BH |
Gene summary for HIST1H2BH |
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Gene information | Species | Human | Gene symbol | HIST1H2BH | Gene ID | 8345 |
Gene name | H2B clustered histone 9 | |
Gene Alias | H2B/j | |
Cytomap | 6p22.2 | |
Gene Type | protein-coding | GO ID | GO:0006323 | UniProtAcc | Q93079 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8345 | HIST1H2BH | P32T-E | Human | Esophagus | ESCC | 5.50e-03 | 1.46e-01 | 0.1666 |
8345 | HIST1H2BH | P36T-E | Human | Esophagus | ESCC | 1.09e-02 | 1.83e-01 | 0.1187 |
8345 | HIST1H2BH | P37T-E | Human | Esophagus | ESCC | 1.99e-11 | 3.19e-01 | 0.1371 |
8345 | HIST1H2BH | P39T-E | Human | Esophagus | ESCC | 5.50e-04 | 1.20e-01 | 0.0894 |
8345 | HIST1H2BH | P42T-E | Human | Esophagus | ESCC | 5.87e-03 | 2.19e-01 | 0.1175 |
8345 | HIST1H2BH | P44T-E | Human | Esophagus | ESCC | 2.97e-05 | 1.75e-01 | 0.1096 |
8345 | HIST1H2BH | P47T-E | Human | Esophagus | ESCC | 1.17e-10 | 2.78e-01 | 0.1067 |
8345 | HIST1H2BH | P48T-E | Human | Esophagus | ESCC | 2.96e-05 | 2.28e-01 | 0.0959 |
8345 | HIST1H2BH | P49T-E | Human | Esophagus | ESCC | 2.79e-04 | 7.75e-01 | 0.1768 |
8345 | HIST1H2BH | P52T-E | Human | Esophagus | ESCC | 2.36e-22 | 6.28e-01 | 0.1555 |
8345 | HIST1H2BH | P54T-E | Human | Esophagus | ESCC | 4.69e-04 | 2.71e-01 | 0.0975 |
8345 | HIST1H2BH | P61T-E | Human | Esophagus | ESCC | 2.47e-22 | 8.21e-01 | 0.099 |
8345 | HIST1H2BH | P65T-E | Human | Esophagus | ESCC | 5.35e-18 | 4.40e-01 | 0.0978 |
8345 | HIST1H2BH | P74T-E | Human | Esophagus | ESCC | 1.50e-17 | 8.97e-01 | 0.1479 |
8345 | HIST1H2BH | P75T-E | Human | Esophagus | ESCC | 3.51e-32 | 6.64e-01 | 0.1125 |
8345 | HIST1H2BH | P79T-E | Human | Esophagus | ESCC | 1.76e-25 | 7.20e-01 | 0.1154 |
8345 | HIST1H2BH | P83T-E | Human | Esophagus | ESCC | 2.08e-12 | 5.21e-01 | 0.1738 |
8345 | HIST1H2BH | P89T-E | Human | Esophagus | ESCC | 4.64e-19 | 1.04e+00 | 0.1752 |
8345 | HIST1H2BH | P91T-E | Human | Esophagus | ESCC | 1.69e-14 | 1.44e+00 | 0.1828 |
8345 | HIST1H2BH | P107T-E | Human | Esophagus | ESCC | 1.48e-10 | 3.38e-01 | 0.171 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HIST1H2BH | SNV | Missense_Mutation | c.205G>A | p.Asp69Asn | p.D69N | Q93079 | protein_coding | deleterious_low_confidence(0.05) | benign(0.251) | TCGA-3C-AALI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Poly E | Complete Response | |
HIST1H2BH | SNV | Missense_Mutation | c.229G>A | p.Glu77Lys | p.E77K | Q93079 | protein_coding | deleterious_low_confidence(0.04) | possibly_damaging(0.812) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
HIST1H2BH | SNV | Missense_Mutation | c.229N>C | p.Glu77Gln | p.E77Q | Q93079 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.975) | TCGA-AC-A6IW-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2BH | SNV | Missense_Mutation | c.340N>C | p.Glu114Gln | p.E114Q | Q93079 | protein_coding | deleterious_low_confidence(0.02) | benign(0.155) | TCGA-DG-A2KK-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | |
HIST1H2BH | SNV | Missense_Mutation | c.69N>C | p.Gln23His | p.Q23H | Q93079 | protein_coding | deleterious_low_confidence(0.01) | benign(0.012) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2BH | SNV | Missense_Mutation | c.331N>A | p.Ala111Thr | p.A111T | Q93079 | protein_coding | tolerated_low_confidence(0.06) | benign(0.079) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
HIST1H2BH | SNV | Missense_Mutation | c.340N>A | p.Glu114Lys | p.E114K | Q93079 | protein_coding | tolerated_low_confidence(0.07) | benign(0.034) | TCGA-AG-4001-01 | Colorectum | rectum adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
HIST1H2BH | SNV | Missense_Mutation | rs759587313 | c.88N>T | p.Arg30Cys | p.R30C | Q93079 | protein_coding | tolerated_low_confidence(0.09) | benign(0.082) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
HIST1H2BH | SNV | Missense_Mutation | novel | c.217N>T | p.Arg73Cys | p.R73C | Q93079 | protein_coding | tolerated_low_confidence(0.11) | benign(0.041) | TCGA-EO-A22T-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
HIST1H2BH | SNV | Missense_Mutation | c.205G>C | p.Asp69His | p.D69H | Q93079 | protein_coding | deleterious_low_confidence(0.01) | possibly_damaging(0.597) | TCGA-05-4410-01 | Lung | lung adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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