|
|||||
|
 | |
| |
| |
| |
| |
| |
|
Gene: HIST1H2AM |
Gene summary for HIST1H2AM |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | HIST1H2AM | Gene ID | 8336 |
| Gene name | H2A clustered histone 17 | |
| Gene Alias | H2A.1 | |
| Cytomap | 6p22.1 | |
| Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | A4FTV9 |
Top |
Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 8336 | HIST1H2AM | P24T-E | Human | Esophagus | ESCC | 1.88e-04 | 1.16e-01 | 0.1287 |
| 8336 | HIST1H2AM | P26T-E | Human | Esophagus | ESCC | 9.44e-07 | 1.87e-01 | 0.1276 |
| 8336 | HIST1H2AM | P27T-E | Human | Esophagus | ESCC | 3.89e-12 | 2.97e-01 | 0.1055 |
| 8336 | HIST1H2AM | P28T-E | Human | Esophagus | ESCC | 8.84e-05 | 1.28e-01 | 0.1149 |
| 8336 | HIST1H2AM | P30T-E | Human | Esophagus | ESCC | 7.79e-07 | 2.55e-01 | 0.137 |
| 8336 | HIST1H2AM | P31T-E | Human | Esophagus | ESCC | 3.97e-04 | 1.50e-01 | 0.1251 |
| 8336 | HIST1H2AM | P37T-E | Human | Esophagus | ESCC | 8.12e-03 | 1.08e-01 | 0.1371 |
| 8336 | HIST1H2AM | P39T-E | Human | Esophagus | ESCC | 1.66e-02 | 7.24e-02 | 0.0894 |
| 8336 | HIST1H2AM | P42T-E | Human | Esophagus | ESCC | 2.93e-03 | 1.26e-01 | 0.1175 |
| 8336 | HIST1H2AM | P47T-E | Human | Esophagus | ESCC | 4.31e-06 | 1.58e-01 | 0.1067 |
| 8336 | HIST1H2AM | P48T-E | Human | Esophagus | ESCC | 1.97e-10 | 3.20e-01 | 0.0959 |
| 8336 | HIST1H2AM | P49T-E | Human | Esophagus | ESCC | 5.57e-05 | 4.05e-01 | 0.1768 |
| 8336 | HIST1H2AM | P52T-E | Human | Esophagus | ESCC | 8.08e-19 | 4.19e-01 | 0.1555 |
| 8336 | HIST1H2AM | P54T-E | Human | Esophagus | ESCC | 7.29e-13 | 6.51e-01 | 0.0975 |
| 8336 | HIST1H2AM | P56T-E | Human | Esophagus | ESCC | 1.16e-08 | 7.37e-01 | 0.1613 |
| 8336 | HIST1H2AM | P61T-E | Human | Esophagus | ESCC | 1.44e-31 | 1.09e+00 | 0.099 |
| 8336 | HIST1H2AM | P65T-E | Human | Esophagus | ESCC | 2.17e-24 | 5.29e-01 | 0.0978 |
| 8336 | HIST1H2AM | P74T-E | Human | Esophagus | ESCC | 2.69e-06 | 2.67e-01 | 0.1479 |
| 8336 | HIST1H2AM | P75T-E | Human | Esophagus | ESCC | 9.74e-22 | 4.16e-01 | 0.1125 |
| 8336 | HIST1H2AM | P76T-E | Human | Esophagus | ESCC | 1.66e-02 | 1.49e-01 | 0.1207 |
| Page: 1 2 3 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
Top |
Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| HIST1H2AM | insertion | Frame_Shift_Ins | novel | c.227_228insA | p.Thr77AspfsTer24 | p.T77Dfs*24 | P0C0S8 | protein_coding | TCGA-AN-A0AK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
| HIST1H2AM | SNV | Missense_Mutation | rs571168598 | c.50C>T | p.Thr17Ile | p.T17I | P0C0S8 | protein_coding | deleterious_low_confidence(0) | benign(0.003) | TCGA-NH-A5IV-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| HIST1H2AM | insertion | Frame_Shift_Ins | novel | c.383_384insA | p.Lys130GlnfsTer? | p.K130Qfs*? | P0C0S8 | protein_coding | TCGA-WS-AB45-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
| HIST1H2AM | SNV | Missense_Mutation | novel | c.366G>T | p.Glu122Asp | p.E122D | P0C0S8 | protein_coding | tolerated_low_confidence(0.16) | benign(0) | TCGA-AJ-A3EK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| HIST1H2AM | SNV | Missense_Mutation | novel | c.130N>A | p.Val44Ile | p.V44I | P0C0S8 | protein_coding | tolerated_low_confidence(0.41) | benign(0.06) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| HIST1H2AM | SNV | Missense_Mutation | c.229A>G | p.Thr77Ala | p.T77A | P0C0S8 | protein_coding | deleterious_low_confidence(0.03) | benign(0.007) | TCGA-D1-A0ZR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| HIST1H2AM | SNV | Missense_Mutation | c.266N>A | p.Arg89His | p.R89H | P0C0S8 | protein_coding | deleterious_low_confidence(0.02) | probably_damaging(0.995) | TCGA-D1-A17Q-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
| HIST1H2AM | SNV | Missense_Mutation | novel | c.172N>A | p.Tyr58Asn | p.Y58N | P0C0S8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.997) | TCGA-FI-A2EW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Chemotherapy | carboplatinum | PD |
| HIST1H2AM | insertion | Frame_Shift_Ins | novel | c.344_345insGT | p.Leu116TyrfsTer? | p.L116Yfs*? | P0C0S8 | protein_coding | TCGA-AX-A2H5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Chemotherapy | carboplatin | CR | ||
| HIST1H2AM | SNV | Missense_Mutation | c.22N>T | p.Gly8Cys | p.G8C | P0C0S8 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.975) | TCGA-80-5611-01 | Lung | lung adenocarcinoma | Male | Unknown | I/II | Unknown | Unknown | SD |
| Page: 1 2 |
Top |
Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
Copyright 2023-Present -The University of Texas Health Science Center at Houston |