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Gene: HFM1 |
Gene summary for HFM1 |
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Gene information | Species | Human | Gene symbol | HFM1 | Gene ID | 164045 |
Gene name | helicase for meiosis 1 | |
Gene Alias | MER3 | |
Cytomap | 1p22.2 | |
Gene Type | protein-coding | GO ID | GO:0000003 | UniProtAcc | A2PYH4 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
164045 | HFM1 | HTA11_4255_2000001011 | Human | Colorectum | SER | 1.99e-11 | 6.66e-01 | 0.0446 |
164045 | HFM1 | HTA11_9408_2000001011 | Human | Colorectum | AD | 1.21e-14 | 8.59e-01 | 0.0451 |
164045 | HFM1 | HTA11_8622_2000001021 | Human | Colorectum | SER | 1.31e-03 | 2.39e-01 | 0.0528 |
164045 | HFM1 | HTA11_7663_2000001011 | Human | Colorectum | SER | 1.16e-07 | 4.91e-01 | 0.0131 |
164045 | HFM1 | HTA11_10623_2000001011 | Human | Colorectum | AD | 9.35e-10 | 7.38e-01 | -0.0177 |
164045 | HFM1 | HTA11_10711_2000001011 | Human | Colorectum | AD | 4.17e-27 | 8.01e-01 | 0.0338 |
164045 | HFM1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 1.75e-18 | 3.30e-01 | 0.0674 |
164045 | HFM1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 1.43e-09 | 5.99e-01 | 0.0112 |
164045 | HFM1 | HTA11_11156_2000001011 | Human | Colorectum | AD | 5.95e-06 | 5.94e-01 | 0.0397 |
164045 | HFM1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 7.32e-37 | 1.27e+00 | 0.0588 |
164045 | HFM1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 2.91e-17 | 4.44e-01 | 0.294 |
164045 | HFM1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 4.02e-05 | 7.15e-01 | 0.3487 |
164045 | HFM1 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 4.07e-08 | 4.29e-01 | 0.281 |
164045 | HFM1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 6.56e-26 | 4.58e-01 | 0.3859 |
164045 | HFM1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.52e-17 | 3.67e-01 | 0.3005 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0032392 | Colorectum | AD | DNA geometric change | 31/3918 | 90/18723 | 2.02e-03 | 1.63e-02 | 31 |
GO:00323921 | Colorectum | MSS | DNA geometric change | 29/3467 | 90/18723 | 1.26e-03 | 1.20e-02 | 29 |
GO:0032508 | Colorectum | MSS | DNA duplex unwinding | 25/3467 | 84/18723 | 8.27e-03 | 4.99e-02 | 25 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
HFM1 | SNV | Missense_Mutation | c.2428N>T | p.Val810Phe | p.V810F | A2PYH4 | protein_coding | tolerated(0.06) | benign(0.315) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | c.4229N>C | p.Val1410Ala | p.V1410A | A2PYH4 | protein_coding | tolerated_low_confidence(0.1) | benign(0) | TCGA-B6-A0RN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
HFM1 | SNV | Missense_Mutation | c.4187N>C | p.Lys1396Thr | p.K1396T | A2PYH4 | protein_coding | deleterious_low_confidence(0.02) | benign(0.04) | TCGA-C8-A1HO-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | |
HFM1 | SNV | Missense_Mutation | c.310N>G | p.Leu104Val | p.L104V | A2PYH4 | protein_coding | deleterious_low_confidence(0.03) | benign(0.075) | TCGA-E2-A14P-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Targeted Molecular therapy | trastuzumab | SD | |
HFM1 | insertion | Frame_Shift_Ins | novel | c.2495_2496insTGCCTCAACA | p.Asn833AlafsTer24 | p.N833Afs*24 | A2PYH4 | protein_coding | TCGA-AR-A0TU-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Doxorubicin | SD | ||
HFM1 | insertion | Frame_Shift_Ins | novel | c.3598_3599insTT | p.Asn1200IlefsTer29 | p.N1200Ifs*29 | A2PYH4 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HFM1 | insertion | In_Frame_Ins | novel | c.3597_3598insTGTAATTTTCGT | p.Met1199_Asn1200insCysAsnPheArg | p.M1199_N1200insCNFR | A2PYH4 | protein_coding | TCGA-AR-A0U0-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
HFM1 | insertion | Frame_Shift_Ins | novel | c.577_578insGTTT | p.Ile193SerfsTer16 | p.I193Sfs*16 | A2PYH4 | protein_coding | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | ||
HFM1 | insertion | Frame_Shift_Ins | novel | c.576_577insC | p.Ile193HisfsTer15 | p.I193Hfs*15 | A2PYH4 | protein_coding | TCGA-BH-A0H7-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD | ||
HFM1 | SNV | Missense_Mutation | novel | c.1460G>T | p.Arg487Ile | p.R487I | A2PYH4 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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