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Gene: GUCD1 |
Gene summary for GUCD1 |
Gene summary. |
Gene information | Species | Human | Gene symbol | GUCD1 | Gene ID | 83606 |
Gene name | guanylyl cyclase domain containing 1 | |
Gene Alias | C22orf13 | |
Cytomap | 22q11.23 | |
Gene Type | protein-coding | GO ID | GO:0003674 | UniProtAcc | A0A087WVD9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
83606 | GUCD1 | HTA11_7696_3000711011 | Human | Colorectum | AD | 6.06e-09 | 2.86e-01 | 0.0674 |
83606 | GUCD1 | HTA11_6818_2000001011 | Human | Colorectum | AD | 2.89e-03 | 3.80e-01 | 0.0112 |
83606 | GUCD1 | HTA11_6818_2000001021 | Human | Colorectum | AD | 3.97e-02 | 2.15e-01 | 0.0588 |
83606 | GUCD1 | HTA11_99999970781_79442 | Human | Colorectum | MSS | 7.09e-03 | 1.54e-01 | 0.294 |
83606 | GUCD1 | HTA11_99999965062_69753 | Human | Colorectum | MSI-H | 3.80e-11 | 1.20e+00 | 0.3487 |
83606 | GUCD1 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 1.64e-28 | 6.83e-01 | 0.3859 |
83606 | GUCD1 | HTA11_99999973899_84307 | Human | Colorectum | MSS | 1.93e-09 | 5.01e-01 | 0.2585 |
83606 | GUCD1 | HTA11_99999974143_84620 | Human | Colorectum | MSS | 1.96e-12 | 3.23e-01 | 0.3005 |
83606 | GUCD1 | LZE5T | Human | Esophagus | ESCC | 1.31e-03 | 2.34e-01 | 0.0514 |
83606 | GUCD1 | LZE7T | Human | Esophagus | ESCC | 5.15e-07 | 3.09e-01 | 0.0667 |
83606 | GUCD1 | LZE8T | Human | Esophagus | ESCC | 2.69e-02 | 1.15e-01 | 0.067 |
83606 | GUCD1 | LZE24T | Human | Esophagus | ESCC | 2.34e-18 | 4.54e-01 | 0.0596 |
83606 | GUCD1 | LZE21T | Human | Esophagus | ESCC | 5.17e-03 | 1.79e-01 | 0.0655 |
83606 | GUCD1 | P1T-E | Human | Esophagus | ESCC | 1.65e-03 | 1.85e-01 | 0.0875 |
83606 | GUCD1 | P2T-E | Human | Esophagus | ESCC | 9.67e-19 | 3.02e-01 | 0.1177 |
83606 | GUCD1 | P4T-E | Human | Esophagus | ESCC | 8.44e-17 | 2.47e-01 | 0.1323 |
83606 | GUCD1 | P5T-E | Human | Esophagus | ESCC | 8.08e-16 | 4.56e-02 | 0.1327 |
83606 | GUCD1 | P8T-E | Human | Esophagus | ESCC | 6.35e-14 | 2.64e-01 | 0.0889 |
83606 | GUCD1 | P9T-E | Human | Esophagus | ESCC | 6.62e-12 | 2.58e-01 | 0.1131 |
83606 | GUCD1 | P10T-E | Human | Esophagus | ESCC | 4.46e-18 | 2.97e-01 | 0.116 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GUCD1 | SNV | Missense_Mutation | novel | c.515T>G | p.Phe172Cys | p.F172C | protein_coding | deleterious(0.02) | possibly_damaging(0.882) | TCGA-AN-A046-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | c.703N>T | p.Arg235Cys | p.R235C | protein_coding | deleterious(0.01) | benign(0.013) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
GUCD1 | SNV | Missense_Mutation | rs747949402 | c.599N>G | p.His200Arg | p.H200R | protein_coding | tolerated(0.21) | possibly_damaging(0.457) | TCGA-A6-6780-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | novel | c.128N>T | p.Ala43Val | p.A43V | protein_coding | tolerated_low_confidence(0.3) | benign(0.003) | TCGA-CK-4951-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GUCD1 | SNV | Missense_Mutation | novel | c.416N>A | p.Arg139His | p.R139H | protein_coding | tolerated(0.35) | benign(0.067) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | novel | c.824N>C | p.Asn275Thr | p.N275T | protein_coding | tolerated(0.19) | possibly_damaging(0.889) | TCGA-A5-A2K5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | c.863A>G | p.Asp288Gly | p.D288G | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
GUCD1 | SNV | Missense_Mutation | c.496A>G | p.Thr166Ala | p.T166A | protein_coding | tolerated(0.65) | benign(0.039) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD | ||
GUCD1 | SNV | Missense_Mutation | rs141621665 | c.733N>A | p.Val245Met | p.V245M | protein_coding | deleterious(0) | probably_damaging(0.992) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GUCD1 | SNV | Missense_Mutation | rs191716304 | c.499N>T | p.Arg167Trp | p.R167W | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AX-A05U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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