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Gene: GTPBP6 |
Gene summary for GTPBP6 |
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Gene information | Species | Human | Gene symbol | GTPBP6 | Gene ID | 8225 |
Gene name | GTP binding protein 6 (putative) | |
Gene Alias | PGPL | |
Cytomap | X | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | H0Y2S1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
8225 | GTPBP6 | P28T-E | Human | Esophagus | ESCC | 4.27e-28 | 5.79e-01 | 0.1149 |
8225 | GTPBP6 | P30T-E | Human | Esophagus | ESCC | 1.93e-18 | 6.80e-01 | 0.137 |
8225 | GTPBP6 | P31T-E | Human | Esophagus | ESCC | 5.69e-05 | 6.67e-02 | 0.1251 |
8225 | GTPBP6 | P32T-E | Human | Esophagus | ESCC | 4.26e-08 | 1.72e-01 | 0.1666 |
8225 | GTPBP6 | P36T-E | Human | Esophagus | ESCC | 2.05e-06 | 1.51e-01 | 0.1187 |
8225 | GTPBP6 | P37T-E | Human | Esophagus | ESCC | 3.09e-11 | 2.59e-01 | 0.1371 |
8225 | GTPBP6 | P38T-E | Human | Esophagus | ESCC | 2.94e-06 | 2.20e-01 | 0.127 |
8225 | GTPBP6 | P40T-E | Human | Esophagus | ESCC | 2.27e-05 | 1.16e-01 | 0.109 |
8225 | GTPBP6 | P42T-E | Human | Esophagus | ESCC | 5.73e-09 | 2.56e-01 | 0.1175 |
8225 | GTPBP6 | P44T-E | Human | Esophagus | ESCC | 3.82e-07 | 1.16e-01 | 0.1096 |
8225 | GTPBP6 | P47T-E | Human | Esophagus | ESCC | 6.38e-13 | 3.21e-01 | 0.1067 |
8225 | GTPBP6 | P48T-E | Human | Esophagus | ESCC | 1.94e-12 | 1.27e-01 | 0.0959 |
8225 | GTPBP6 | P52T-E | Human | Esophagus | ESCC | 1.42e-06 | 2.56e-01 | 0.1555 |
8225 | GTPBP6 | P54T-E | Human | Esophagus | ESCC | 1.18e-17 | 3.71e-01 | 0.0975 |
8225 | GTPBP6 | P56T-E | Human | Esophagus | ESCC | 1.59e-06 | 9.70e-01 | 0.1613 |
8225 | GTPBP6 | P57T-E | Human | Esophagus | ESCC | 1.11e-08 | 1.47e-01 | 0.0926 |
8225 | GTPBP6 | P61T-E | Human | Esophagus | ESCC | 1.18e-13 | 3.63e-01 | 0.099 |
8225 | GTPBP6 | P62T-E | Human | Esophagus | ESCC | 4.56e-08 | 1.07e-01 | 0.1302 |
8225 | GTPBP6 | P65T-E | Human | Esophagus | ESCC | 2.65e-07 | 1.13e-01 | 0.0978 |
8225 | GTPBP6 | P74T-E | Human | Esophagus | ESCC | 8.07e-08 | 2.38e-01 | 0.1479 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTPBP6 | SNV | Missense_Mutation | rs759439115 | c.835N>T | p.Arg279Cys | p.R279C | protein_coding | deleterious(0.02) | benign(0.139) | TCGA-D8-A27G-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | rs372906272 | c.1318N>T | p.Arg440Trp | p.R440W | protein_coding | deleterious(0.05) | possibly_damaging(0.827) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GTPBP6 | SNV | Missense_Mutation | rs367857545 | c.836N>A | p.Arg279His | p.R279H | protein_coding | deleterious(0) | probably_damaging(0.944) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
GTPBP6 | SNV | Missense_Mutation | c.825N>C | p.Leu275Phe | p.L275F | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-DR-A0ZM-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unspecific | Cisplatin | SD | ||
GTPBP6 | insertion | Frame_Shift_Ins | novel | c.926_927insCGTC | p.Leu310ValfsTer142 | p.L310Vfs*142 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |||
GTPBP6 | insertion | Frame_Shift_Ins | novel | c.924_925insCGACGCGTGGGACAAAGCC | p.Thr309ArgfsTer148 | p.T309Rfs*148 | protein_coding | TCGA-DS-A1OB-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |||
GTPBP6 | SNV | Missense_Mutation | rs372906272 | c.1318N>T | p.Arg440Trp | p.R440W | protein_coding | deleterious(0.05) | possibly_damaging(0.827) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD | |
GTPBP6 | SNV | Missense_Mutation | novel | c.1472N>T | p.Pro491Leu | p.P491L | protein_coding | deleterious(0.01) | probably_damaging(0.984) | TCGA-AD-6964-01 | Colorectum | colon adenocarcinoma | Male | <65 | III/IV | Chemotherapy | folfox | PD | |
GTPBP6 | SNV | Missense_Mutation | rs368127298 | c.740N>A | p.Arg247His | p.R247H | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AZ-6598-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GTPBP6 | SNV | Missense_Mutation | rs757364188 | c.1303N>T | p.Pro435Ser | p.P435S | protein_coding | tolerated(0.17) | benign(0.281) | TCGA-QG-A5Z2-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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