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Gene: GTF2F1 |
Gene summary for GTF2F1 |
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Gene information | Species | Human | Gene symbol | GTF2F1 | Gene ID | 2962 |
Gene name | general transcription factor IIF subunit 1 | |
Gene Alias | BTF4 | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P35269 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2962 | GTF2F1 | P19T-E | Human | Esophagus | ESCC | 1.84e-06 | 9.27e-01 | 0.1662 |
2962 | GTF2F1 | P20T-E | Human | Esophagus | ESCC | 2.78e-16 | 4.00e-01 | 0.1124 |
2962 | GTF2F1 | P21T-E | Human | Esophagus | ESCC | 3.81e-24 | 4.61e-01 | 0.1617 |
2962 | GTF2F1 | P22T-E | Human | Esophagus | ESCC | 1.24e-31 | 5.73e-01 | 0.1236 |
2962 | GTF2F1 | P23T-E | Human | Esophagus | ESCC | 5.59e-37 | 9.27e-01 | 0.108 |
2962 | GTF2F1 | P24T-E | Human | Esophagus | ESCC | 9.54e-31 | 5.74e-01 | 0.1287 |
2962 | GTF2F1 | P26T-E | Human | Esophagus | ESCC | 3.48e-38 | 6.95e-01 | 0.1276 |
2962 | GTF2F1 | P27T-E | Human | Esophagus | ESCC | 2.39e-29 | 5.55e-01 | 0.1055 |
2962 | GTF2F1 | P28T-E | Human | Esophagus | ESCC | 1.77e-39 | 8.18e-01 | 0.1149 |
2962 | GTF2F1 | P30T-E | Human | Esophagus | ESCC | 2.43e-28 | 1.10e+00 | 0.137 |
2962 | GTF2F1 | P31T-E | Human | Esophagus | ESCC | 3.52e-37 | 5.46e-01 | 0.1251 |
2962 | GTF2F1 | P32T-E | Human | Esophagus | ESCC | 3.19e-46 | 9.00e-01 | 0.1666 |
2962 | GTF2F1 | P36T-E | Human | Esophagus | ESCC | 1.41e-14 | 4.79e-01 | 0.1187 |
2962 | GTF2F1 | P37T-E | Human | Esophagus | ESCC | 3.86e-26 | 6.37e-01 | 0.1371 |
2962 | GTF2F1 | P38T-E | Human | Esophagus | ESCC | 4.92e-11 | 4.96e-01 | 0.127 |
2962 | GTF2F1 | P39T-E | Human | Esophagus | ESCC | 2.32e-23 | 4.90e-01 | 0.0894 |
2962 | GTF2F1 | P40T-E | Human | Esophagus | ESCC | 3.18e-14 | 4.99e-01 | 0.109 |
2962 | GTF2F1 | P42T-E | Human | Esophagus | ESCC | 1.48e-23 | 6.16e-01 | 0.1175 |
2962 | GTF2F1 | P44T-E | Human | Esophagus | ESCC | 6.00e-12 | 3.52e-01 | 0.1096 |
2962 | GTF2F1 | P47T-E | Human | Esophagus | ESCC | 3.80e-22 | 2.33e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0051098111 | Esophagus | ESCC | regulation of binding | 251/8552 | 363/18723 | 6.73e-20 | 8.46e-18 | 251 |
GO:000961518 | Esophagus | ESCC | response to virus | 238/8552 | 367/18723 | 6.65e-14 | 3.32e-12 | 238 |
GO:000635414 | Esophagus | ESCC | DNA-templated transcription, elongation | 76/8552 | 91/18723 | 8.35e-14 | 4.11e-12 | 76 |
GO:004339320 | Esophagus | ESCC | regulation of protein binding | 135/8552 | 196/18723 | 3.69e-11 | 1.22e-09 | 135 |
GO:000636814 | Esophagus | ESCC | transcription elongation from RNA polymerase II promoter | 56/8552 | 69/18723 | 1.40e-09 | 3.30e-08 | 56 |
GO:003278412 | Esophagus | ESCC | regulation of DNA-templated transcription, elongation | 45/8552 | 53/18723 | 3.64e-09 | 7.61e-08 | 45 |
GO:0051100111 | Esophagus | ESCC | negative regulation of binding | 109/8552 | 162/18723 | 2.10e-08 | 4.03e-07 | 109 |
GO:003424312 | Esophagus | ESCC | regulation of transcription elongation from RNA polymerase II promoter | 28/8552 | 32/18723 | 1.02e-06 | 1.29e-05 | 28 |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:003209116 | Esophagus | ESCC | negative regulation of protein binding | 65/8552 | 94/18723 | 3.46e-06 | 3.82e-05 | 65 |
GO:003278613 | Esophagus | ESCC | positive regulation of DNA-templated transcription, elongation | 24/8552 | 27/18723 | 3.48e-06 | 3.84e-05 | 24 |
GO:003296812 | Esophagus | ESCC | positive regulation of transcription elongation from RNA polymerase II promoter | 12/8552 | 13/18723 | 6.18e-04 | 3.32e-03 | 12 |
GO:005109812 | Liver | Cirrhotic | regulation of binding | 148/4634 | 363/18723 | 9.14e-12 | 5.97e-10 | 148 |
GO:004339312 | Liver | Cirrhotic | regulation of protein binding | 83/4634 | 196/18723 | 4.44e-08 | 1.42e-06 | 83 |
GO:00096155 | Liver | Cirrhotic | response to virus | 126/4634 | 367/18723 | 2.10e-05 | 2.77e-04 | 126 |
GO:00511006 | Liver | Cirrhotic | negative regulation of binding | 63/4634 | 162/18723 | 4.54e-05 | 5.31e-04 | 63 |
GO:00320914 | Liver | Cirrhotic | negative regulation of protein binding | 40/4634 | 94/18723 | 1.14e-04 | 1.14e-03 | 40 |
GO:0006367 | Liver | Cirrhotic | transcription initiation from RNA polymerase II promoter | 31/4634 | 77/18723 | 1.91e-03 | 1.20e-02 | 31 |
GO:00063544 | Liver | Cirrhotic | DNA-templated transcription, elongation | 35/4634 | 91/18723 | 2.56e-03 | 1.53e-02 | 35 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTF2F1 | deletion | Frame_Shift_Del | novel | c.1449delN | p.Leu484Ter | p.L484* | P35269 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
GTF2F1 | deletion | Frame_Shift_Del | novel | c.332delN | p.Lys111ArgfsTer8 | p.K111Rfs*8 | P35269 | protein_coding | TCGA-EW-A2FV-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | docetaxel | SD | ||
GTF2F1 | SNV | Missense_Mutation | rs201557731 | c.406N>A | p.Glu136Lys | p.E136K | P35269 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-FU-A3HZ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTF2F1 | SNV | Missense_Mutation | rs148016023 | c.472N>A | p.Glu158Lys | p.E158K | P35269 | protein_coding | deleterious(0) | probably_damaging(0.965) | TCGA-IR-A3LL-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTF2F1 | SNV | Missense_Mutation | novel | c.842N>G | p.Ser281Cys | p.S281C | P35269 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-VS-A94Z-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
GTF2F1 | SNV | Missense_Mutation | rs147291523 | c.1103C>T | p.Thr368Met | p.T368M | P35269 | protein_coding | deleterious(0.02) | possibly_damaging(0.824) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
GTF2F1 | SNV | Missense_Mutation | rs146571246 | c.1511N>A | p.Arg504His | p.R504H | P35269 | protein_coding | deleterious(0.01) | benign(0.142) | TCGA-AA-3715-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GTF2F1 | SNV | Missense_Mutation | novel | c.1067A>G | p.Glu356Gly | p.E356G | P35269 | protein_coding | tolerated(0.05) | possibly_damaging(0.629) | TCGA-AA-A00N-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
GTF2F1 | SNV | Missense_Mutation | rs201557731 | c.406G>A | p.Glu136Lys | p.E136K | P35269 | protein_coding | deleterious(0) | possibly_damaging(0.83) | TCGA-AA-A01P-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
GTF2F1 | SNV | Missense_Mutation | novel | c.989N>T | p.Pro330Leu | p.P330L | P35269 | protein_coding | tolerated(0.1) | benign(0.15) | TCGA-AY-4071-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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