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Gene: GTF2E2 |
Gene summary for GTF2E2 |
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Gene information | Species | Human | Gene symbol | GTF2E2 | Gene ID | 2961 |
Gene name | general transcription factor IIE subunit 2 | |
Gene Alias | FE | |
Cytomap | 8p12 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | P29084 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2961 | GTF2E2 | P22T-E | Human | Esophagus | ESCC | 6.90e-31 | 5.61e-01 | 0.1236 |
2961 | GTF2E2 | P23T-E | Human | Esophagus | ESCC | 3.29e-26 | 8.23e-01 | 0.108 |
2961 | GTF2E2 | P24T-E | Human | Esophagus | ESCC | 8.64e-41 | 8.29e-01 | 0.1287 |
2961 | GTF2E2 | P26T-E | Human | Esophagus | ESCC | 3.26e-67 | 1.09e+00 | 0.1276 |
2961 | GTF2E2 | P27T-E | Human | Esophagus | ESCC | 2.91e-28 | 5.59e-01 | 0.1055 |
2961 | GTF2E2 | P28T-E | Human | Esophagus | ESCC | 1.58e-48 | 8.51e-01 | 0.1149 |
2961 | GTF2E2 | P30T-E | Human | Esophagus | ESCC | 6.12e-27 | 9.29e-01 | 0.137 |
2961 | GTF2E2 | P31T-E | Human | Esophagus | ESCC | 6.65e-25 | 4.60e-01 | 0.1251 |
2961 | GTF2E2 | P32T-E | Human | Esophagus | ESCC | 1.21e-27 | 5.22e-01 | 0.1666 |
2961 | GTF2E2 | P36T-E | Human | Esophagus | ESCC | 1.55e-28 | 8.81e-01 | 0.1187 |
2961 | GTF2E2 | P37T-E | Human | Esophagus | ESCC | 1.08e-24 | 6.04e-01 | 0.1371 |
2961 | GTF2E2 | P38T-E | Human | Esophagus | ESCC | 2.52e-13 | 6.12e-01 | 0.127 |
2961 | GTF2E2 | P39T-E | Human | Esophagus | ESCC | 2.24e-30 | 5.48e-01 | 0.0894 |
2961 | GTF2E2 | P40T-E | Human | Esophagus | ESCC | 4.63e-22 | 5.33e-01 | 0.109 |
2961 | GTF2E2 | P42T-E | Human | Esophagus | ESCC | 1.72e-16 | 5.16e-01 | 0.1175 |
2961 | GTF2E2 | P44T-E | Human | Esophagus | ESCC | 8.10e-10 | 1.59e-01 | 0.1096 |
2961 | GTF2E2 | P47T-E | Human | Esophagus | ESCC | 1.53e-15 | 3.78e-01 | 0.1067 |
2961 | GTF2E2 | P48T-E | Human | Esophagus | ESCC | 5.08e-21 | 5.40e-01 | 0.0959 |
2961 | GTF2E2 | P49T-E | Human | Esophagus | ESCC | 1.84e-13 | 1.42e+00 | 0.1768 |
2961 | GTF2E2 | P52T-E | Human | Esophagus | ESCC | 2.18e-28 | 6.23e-01 | 0.1555 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00063673 | Esophagus | ESCC | transcription initiation from RNA polymerase II promoter | 56/8552 | 77/18723 | 1.30e-06 | 1.59e-05 | 56 |
GO:000635211 | Esophagus | ESCC | DNA-templated transcription, initiation | 86/8552 | 130/18723 | 1.88e-06 | 2.19e-05 | 86 |
GO:0006367 | Liver | Cirrhotic | transcription initiation from RNA polymerase II promoter | 31/4634 | 77/18723 | 1.91e-03 | 1.20e-02 | 31 |
GO:00063671 | Liver | HCC | transcription initiation from RNA polymerase II promoter | 52/7958 | 77/18723 | 7.87e-06 | 9.27e-05 | 52 |
GO:0006352 | Liver | HCC | DNA-templated transcription, initiation | 78/7958 | 130/18723 | 4.19e-05 | 4.11e-04 | 78 |
GO:00063522 | Oral cavity | OSCC | DNA-templated transcription, initiation | 74/7305 | 130/18723 | 2.56e-05 | 2.39e-04 | 74 |
GO:00063672 | Oral cavity | OSCC | transcription initiation from RNA polymerase II promoter | 46/7305 | 77/18723 | 1.82e-04 | 1.24e-03 | 46 |
GO:000636711 | Oral cavity | LP | transcription initiation from RNA polymerase II promoter | 31/4623 | 77/18723 | 1.83e-03 | 1.38e-02 | 31 |
GO:00063521 | Oral cavity | LP | DNA-templated transcription, initiation | 45/4623 | 130/18723 | 7.03e-03 | 3.96e-02 | 45 |
GO:000635212 | Skin | cSCC | DNA-templated transcription, initiation | 57/4864 | 130/18723 | 7.28e-06 | 1.01e-04 | 57 |
GO:00063674 | Skin | cSCC | transcription initiation from RNA polymerase II promoter | 37/4864 | 77/18723 | 2.53e-05 | 2.87e-04 | 37 |
GO:00063675 | Thyroid | PTC | transcription initiation from RNA polymerase II promoter | 44/5968 | 77/18723 | 4.04e-06 | 5.05e-05 | 44 |
GO:00063525 | Thyroid | PTC | DNA-templated transcription, initiation | 63/5968 | 130/18723 | 5.72e-05 | 5.05e-04 | 63 |
GO:000636712 | Thyroid | ATC | transcription initiation from RNA polymerase II promoter | 44/6293 | 77/18723 | 1.86e-05 | 1.70e-04 | 44 |
GO:000635213 | Thyroid | ATC | DNA-templated transcription, initiation | 64/6293 | 130/18723 | 1.60e-04 | 1.10e-03 | 64 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0520325 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa030222 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa0520335 | Esophagus | ESCC | Viral carcinogenesis | 137/4205 | 204/8465 | 2.47e-07 | 1.88e-06 | 9.62e-07 | 137 |
hsa0302211 | Esophagus | ESCC | Basal transcription factors | 35/4205 | 45/8465 | 1.01e-04 | 4.06e-04 | 2.08e-04 | 35 |
hsa05203 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052031 | Liver | Cirrhotic | Viral carcinogenesis | 76/2530 | 204/8465 | 1.34e-02 | 4.20e-02 | 2.59e-02 | 76 |
hsa052032 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa052033 | Liver | HCC | Viral carcinogenesis | 117/4020 | 204/8465 | 2.68e-03 | 8.98e-03 | 5.00e-03 | 117 |
hsa052038 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa03022 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
hsa0520314 | Oral cavity | OSCC | Viral carcinogenesis | 124/3704 | 204/8465 | 5.57e-07 | 3.28e-06 | 1.67e-06 | 124 |
hsa030221 | Oral cavity | OSCC | Basal transcription factors | 28/3704 | 45/8465 | 9.53e-03 | 2.11e-02 | 1.08e-02 | 28 |
hsa0520324 | Oral cavity | LP | Viral carcinogenesis | 90/2418 | 204/8465 | 1.20e-06 | 1.38e-05 | 8.89e-06 | 90 |
hsa0520334 | Oral cavity | LP | Viral carcinogenesis | 90/2418 | 204/8465 | 1.20e-06 | 1.38e-05 | 8.89e-06 | 90 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GTF2E2 | SNV | Missense_Mutation | rs774545618 | c.92N>T | p.Ser31Leu | p.S31L | P29084 | protein_coding | tolerated(0.1) | benign(0.119) | TCGA-BH-A0HP-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Chemotherapy | doxorubicin | SD |
GTF2E2 | SNV | Missense_Mutation | c.386N>G | p.Lys129Arg | p.K129R | P29084 | protein_coding | tolerated(0.05) | possibly_damaging(0.777) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD | |
GTF2E2 | SNV | Missense_Mutation | rs780571452 | c.586N>A | p.Asp196Asn | p.D196N | P29084 | protein_coding | tolerated(0.05) | possibly_damaging(0.762) | TCGA-CA-6718-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | PD |
GTF2E2 | SNV | Missense_Mutation | novel | c.380N>C | p.Asn127Thr | p.N127T | P29084 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF2E2 | SNV | Missense_Mutation | c.823G>A | p.Glu275Lys | p.E275K | P29084 | protein_coding | deleterious(0.01) | benign(0.251) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD | |
GTF2E2 | SNV | Missense_Mutation | novel | c.680C>T | p.Ser227Phe | p.S227F | P29084 | protein_coding | deleterious(0.02) | possibly_damaging(0.862) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
GTF2E2 | SNV | Missense_Mutation | rs760282859 | c.547A>G | p.Lys183Glu | p.K183E | P29084 | protein_coding | tolerated(0.11) | benign(0.225) | TCGA-A5-A0GP-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF2E2 | SNV | Missense_Mutation | rs527328234 | c.581N>A | p.Arg194His | p.R194H | P29084 | protein_coding | deleterious(0.03) | probably_damaging(0.931) | TCGA-AJ-A3BH-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | Unknown | I/II | Unknown | Unknown | SD |
GTF2E2 | SNV | Missense_Mutation | novel | c.49N>A | p.Leu17Ile | p.L17I | P29084 | protein_coding | tolerated(0.18) | possibly_damaging(0.492) | TCGA-AJ-A3EL-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GTF2E2 | SNV | Missense_Mutation | novel | c.160A>C | p.Asn54His | p.N54H | P29084 | protein_coding | tolerated(0.12) | benign(0.336) | TCGA-AJ-A5DW-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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