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Gene: GRM8 |
Gene summary for GRM8 |
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Gene information | Species | Human | Gene symbol | GRM8 | Gene ID | 2918 |
Gene name | glutamate metabotropic receptor 8 | |
Gene Alias | GLUR8 | |
Cytomap | 7q31.33 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | O00222 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2918 | GRM8 | A002-C-116 | Human | Colorectum | FAP | 2.25e-04 | 3.15e-01 | -0.0452 |
2918 | GRM8 | A008-E-015 | Human | Colorectum | FAP | 1.58e-16 | 7.09e-01 | 0.0177 |
2918 | GRM8 | A014-C-008 | Human | Colorectum | FAP | 1.28e-04 | 4.67e-01 | -0.191 |
2918 | GRM8 | F034 | Human | Colorectum | FAP | 3.52e-22 | 7.47e-01 | -0.0665 |
2918 | GRM8 | CRC-1-8810 | Human | Colorectum | CRC | 5.73e-52 | 1.31e+00 | 0.6257 |
2918 | GRM8 | CRC-3-11773 | Human | Colorectum | CRC | 2.14e-09 | 5.50e-01 | 0.2564 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0050804 | Colorectum | CRC | modulation of chemical synaptic transmission | 70/2078 | 439/18723 | 1.15e-03 | 1.33e-02 | 70 |
GO:0099177 | Colorectum | CRC | regulation of trans-synaptic signaling | 70/2078 | 440/18723 | 1.23e-03 | 1.38e-02 | 70 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04724 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
hsa047241 | Colorectum | CRC | Glutamatergic synapse | 24/1091 | 115/8465 | 1.07e-02 | 4.74e-02 | 3.21e-02 | 24 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GRM8 | SNV | Missense_Mutation | c.820N>C | p.Asn274His | p.N274H | O00222 | protein_coding | tolerated(0.08) | benign(0.078) | TCGA-A1-A0SN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | ac | SD | |
GRM8 | SNV | Missense_Mutation | novel | c.727N>T | p.Gly243Cys | p.G243C | O00222 | protein_coding | deleterious(0.01) | probably_damaging(0.999) | TCGA-A7-A6VY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophosphamide | CR |
GRM8 | SNV | Missense_Mutation | c.2533N>T | p.Pro845Ser | p.P845S | O00222 | protein_coding | deleterious(0) | probably_damaging(0.963) | TCGA-A8-A09A-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | |
GRM8 | SNV | Missense_Mutation | c.1859A>G | p.Glu620Gly | p.E620G | O00222 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | c.2630N>T | p.Pro877Leu | p.P877L | O00222 | protein_coding | deleterious(0) | probably_damaging(0.945) | TCGA-AN-A0XN-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD | |
GRM8 | SNV | Missense_Mutation | rs148553836 | c.1697N>A | p.Arg566His | p.R566H | O00222 | protein_coding | tolerated(0.38) | benign(0.02) | TCGA-B6-A0IN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD |
GRM8 | SNV | Missense_Mutation | novel | c.2413N>T | p.Ala805Ser | p.A805S | O00222 | protein_coding | tolerated(0.69) | benign(0.006) | TCGA-E9-A2JS-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | cyclophosphamide | PD |
GRM8 | insertion | Nonsense_Mutation | novel | c.1220_1221insCCATATCTCTACGTAGTC | p.Asp407_Ala408insHisIleSerThrTerSer | p.D407_A408insHIST*S | O00222 | protein_coding | TCGA-AO-A128-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | ||
GRM8 | SNV | Missense_Mutation | rs553795874 | c.1141N>G | p.Ile381Val | p.I381V | O00222 | protein_coding | tolerated(0.68) | benign(0.006) | TCGA-DS-A0VN-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | SD |
GRM8 | SNV | Missense_Mutation | rs767201811 | c.1855C>T | p.Arg619Cys | p.R619C | O00222 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-EA-A3HS-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650554 | EGLUMEGAD | |
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | antagonist | 135650552 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 178102837 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651136 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | allosteric modulator | 381744920 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650507 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651511 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650159 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135651501 | ||
2918 | GRM8 | G PROTEIN COUPLED RECEPTOR, DRUGGABLE GENOME | agonist | 135650510 |
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