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Gene: GOLGA5 |
Gene summary for GOLGA5 |
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Gene information | Species | Human | Gene symbol | GOLGA5 | Gene ID | 9950 |
Gene name | golgin A5 | |
Gene Alias | GOLIM5 | |
Cytomap | 14q32.12 | |
Gene Type | protein-coding | GO ID | GO:0000301 | UniProtAcc | Q8TBA6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
9950 | GOLGA5 | P19T-E | Human | Esophagus | ESCC | 1.68e-07 | 4.96e-01 | 0.1662 |
9950 | GOLGA5 | P20T-E | Human | Esophagus | ESCC | 1.44e-17 | 4.59e-01 | 0.1124 |
9950 | GOLGA5 | P21T-E | Human | Esophagus | ESCC | 9.64e-24 | 4.19e-01 | 0.1617 |
9950 | GOLGA5 | P22T-E | Human | Esophagus | ESCC | 8.21e-23 | 2.98e-01 | 0.1236 |
9950 | GOLGA5 | P23T-E | Human | Esophagus | ESCC | 1.37e-22 | 5.71e-01 | 0.108 |
9950 | GOLGA5 | P24T-E | Human | Esophagus | ESCC | 1.74e-25 | 4.51e-01 | 0.1287 |
9950 | GOLGA5 | P26T-E | Human | Esophagus | ESCC | 1.37e-27 | 5.39e-01 | 0.1276 |
9950 | GOLGA5 | P27T-E | Human | Esophagus | ESCC | 1.93e-26 | 5.33e-01 | 0.1055 |
9950 | GOLGA5 | P28T-E | Human | Esophagus | ESCC | 9.36e-27 | 4.32e-01 | 0.1149 |
9950 | GOLGA5 | P30T-E | Human | Esophagus | ESCC | 9.45e-28 | 9.28e-01 | 0.137 |
9950 | GOLGA5 | P31T-E | Human | Esophagus | ESCC | 4.95e-30 | 4.51e-01 | 0.1251 |
9950 | GOLGA5 | P32T-E | Human | Esophagus | ESCC | 1.44e-38 | 6.66e-01 | 0.1666 |
9950 | GOLGA5 | P36T-E | Human | Esophagus | ESCC | 1.04e-12 | 4.40e-01 | 0.1187 |
9950 | GOLGA5 | P37T-E | Human | Esophagus | ESCC | 1.07e-20 | 4.88e-01 | 0.1371 |
9950 | GOLGA5 | P38T-E | Human | Esophagus | ESCC | 3.40e-04 | 3.23e-01 | 0.127 |
9950 | GOLGA5 | P39T-E | Human | Esophagus | ESCC | 1.57e-12 | 2.04e-01 | 0.0894 |
9950 | GOLGA5 | P40T-E | Human | Esophagus | ESCC | 5.53e-10 | 3.05e-01 | 0.109 |
9950 | GOLGA5 | P42T-E | Human | Esophagus | ESCC | 3.46e-18 | 4.75e-01 | 0.1175 |
9950 | GOLGA5 | P44T-E | Human | Esophagus | ESCC | 5.36e-15 | 3.90e-01 | 0.1096 |
9950 | GOLGA5 | P47T-E | Human | Esophagus | ESCC | 2.06e-12 | 3.22e-01 | 0.1067 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:004819318 | Esophagus | ESCC | Golgi vesicle transport | 231/8552 | 296/18723 | 1.82e-30 | 9.63e-28 | 231 |
GO:00070308 | Esophagus | ESCC | Golgi organization | 101/8552 | 157/18723 | 1.78e-06 | 2.10e-05 | 101 |
GO:00068914 | Esophagus | ESCC | intra-Golgi vesicle-mediated transport | 26/8552 | 33/18723 | 1.06e-04 | 7.43e-04 | 26 |
GO:004819321 | Liver | HCC | Golgi vesicle transport | 217/7958 | 296/18723 | 2.58e-27 | 1.02e-24 | 217 |
GO:00070302 | Liver | HCC | Golgi organization | 99/7958 | 157/18723 | 1.54e-07 | 2.85e-06 | 99 |
GO:0006891 | Liver | HCC | intra-Golgi vesicle-mediated transport | 22/7958 | 33/18723 | 4.38e-03 | 1.90e-02 | 22 |
GO:004819315 | Oral cavity | OSCC | Golgi vesicle transport | 209/7305 | 296/18723 | 1.39e-28 | 6.30e-26 | 209 |
GO:00070307 | Oral cavity | OSCC | Golgi organization | 92/7305 | 157/18723 | 4.96e-07 | 7.27e-06 | 92 |
GO:00068913 | Oral cavity | OSCC | intra-Golgi vesicle-mediated transport | 23/7305 | 33/18723 | 3.47e-04 | 2.12e-03 | 23 |
GO:004819316 | Oral cavity | LP | Golgi vesicle transport | 141/4623 | 296/18723 | 6.11e-18 | 1.06e-15 | 141 |
GO:000689111 | Oral cavity | LP | intra-Golgi vesicle-mediated transport | 16/4623 | 33/18723 | 2.59e-03 | 1.83e-02 | 16 |
GO:0048193110 | Skin | cSCC | Golgi vesicle transport | 153/4864 | 296/18723 | 1.85e-21 | 3.41e-19 | 153 |
GO:00070309 | Skin | cSCC | Golgi organization | 64/4864 | 157/18723 | 3.53e-05 | 3.83e-04 | 64 |
GO:000689112 | Skin | cSCC | intra-Golgi vesicle-mediated transport | 18/4864 | 33/18723 | 4.45e-04 | 3.42e-03 | 18 |
GO:004819320 | Thyroid | PTC | Golgi vesicle transport | 186/5968 | 296/18723 | 3.09e-28 | 1.22e-25 | 186 |
GO:000703010 | Thyroid | PTC | Golgi organization | 79/5968 | 157/18723 | 1.11e-06 | 1.64e-05 | 79 |
GO:00068916 | Thyroid | PTC | intra-Golgi vesicle-mediated transport | 20/5968 | 33/18723 | 6.26e-04 | 3.96e-03 | 20 |
GO:0048193111 | Thyroid | ATC | Golgi vesicle transport | 189/6293 | 296/18723 | 9.58e-27 | 5.05e-24 | 189 |
GO:000703015 | Thyroid | ATC | Golgi organization | 79/6293 | 157/18723 | 1.07e-05 | 1.05e-04 | 79 |
GO:000689113 | Thyroid | ATC | intra-Golgi vesicle-mediated transport | 20/6293 | 33/18723 | 1.33e-03 | 6.96e-03 | 20 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GOLGA5 | SNV | Missense_Mutation | novel | c.803N>G | p.Lys268Arg | p.K268R | Q8TBA6 | protein_coding | tolerated(0.35) | benign(0.047) | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD |
GOLGA5 | SNV | Missense_Mutation | c.604G>T | p.Val202Leu | p.V202L | Q8TBA6 | protein_coding | tolerated(0.33) | benign(0.003) | TCGA-A8-A06Y-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | anastrozole | PD | |
GOLGA5 | SNV | Missense_Mutation | c.1081N>G | p.Leu361Val | p.L361V | Q8TBA6 | protein_coding | tolerated(0.09) | benign(0.442) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
GOLGA5 | SNV | Missense_Mutation | c.804G>C | p.Lys268Asn | p.K268N | Q8TBA6 | protein_coding | tolerated(0.13) | benign(0.084) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
GOLGA5 | insertion | Frame_Shift_Ins | novel | c.801_802insTTTTGTTCTTACT | p.Lys268PhefsTer5 | p.K268Ffs*5 | Q8TBA6 | protein_coding | TCGA-A2-A0EY-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | ||
GOLGA5 | SNV | Missense_Mutation | c.667G>A | p.Glu223Lys | p.E223K | Q8TBA6 | protein_coding | tolerated(0.58) | benign(0.014) | TCGA-DS-A1OC-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | gemcitabine | SD | |
GOLGA5 | SNV | Missense_Mutation | c.389N>T | p.Ser130Leu | p.S130L | Q8TBA6 | protein_coding | deleterious(0.01) | possibly_damaging(0.844) | TCGA-EA-A3HT-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
GOLGA5 | SNV | Missense_Mutation | rs762876362 | c.1189N>A | p.Glu397Lys | p.E397K | Q8TBA6 | protein_coding | deleterious(0) | possibly_damaging(0.851) | TCGA-AA-3510-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
GOLGA5 | SNV | Missense_Mutation | c.982G>A | p.Glu328Lys | p.E328K | Q8TBA6 | protein_coding | deleterious(0) | probably_damaging(0.989) | TCGA-AA-3662-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Chemotherapy | capecitabine | PR | |
GOLGA5 | SNV | Missense_Mutation | c.343A>C | p.Lys115Gln | p.K115Q | Q8TBA6 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-AA-3851-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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