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Gene: GMEB1 |
Gene summary for GMEB1 |
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Gene information | Species | Human | Gene symbol | GMEB1 | Gene ID | 10691 |
Gene name | glucocorticoid modulatory element binding protein 1 | |
Gene Alias | P96PIF | |
Cytomap | 1p35.3 | |
Gene Type | protein-coding | GO ID | GO:0006139 | UniProtAcc | B1AT47 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10691 | GMEB1 | P28T-E | Human | Esophagus | ESCC | 2.95e-06 | 1.19e-01 | 0.1149 |
10691 | GMEB1 | P30T-E | Human | Esophagus | ESCC | 8.64e-06 | 2.75e-01 | 0.137 |
10691 | GMEB1 | P31T-E | Human | Esophagus | ESCC | 9.21e-10 | 2.24e-01 | 0.1251 |
10691 | GMEB1 | P32T-E | Human | Esophagus | ESCC | 7.93e-15 | 2.39e-01 | 0.1666 |
10691 | GMEB1 | P36T-E | Human | Esophagus | ESCC | 4.55e-03 | 2.40e-01 | 0.1187 |
10691 | GMEB1 | P37T-E | Human | Esophagus | ESCC | 4.01e-11 | 1.89e-01 | 0.1371 |
10691 | GMEB1 | P39T-E | Human | Esophagus | ESCC | 1.55e-06 | 1.71e-01 | 0.0894 |
10691 | GMEB1 | P40T-E | Human | Esophagus | ESCC | 9.06e-05 | 1.79e-01 | 0.109 |
10691 | GMEB1 | P42T-E | Human | Esophagus | ESCC | 1.54e-02 | 9.97e-02 | 0.1175 |
10691 | GMEB1 | P47T-E | Human | Esophagus | ESCC | 1.63e-03 | 2.61e-02 | 0.1067 |
10691 | GMEB1 | P48T-E | Human | Esophagus | ESCC | 1.03e-08 | 8.30e-02 | 0.0959 |
10691 | GMEB1 | P49T-E | Human | Esophagus | ESCC | 9.52e-03 | 3.32e-01 | 0.1768 |
10691 | GMEB1 | P52T-E | Human | Esophagus | ESCC | 1.01e-07 | 1.60e-01 | 0.1555 |
10691 | GMEB1 | P54T-E | Human | Esophagus | ESCC | 1.08e-06 | 2.37e-01 | 0.0975 |
10691 | GMEB1 | P56T-E | Human | Esophagus | ESCC | 2.68e-04 | 5.94e-01 | 0.1613 |
10691 | GMEB1 | P57T-E | Human | Esophagus | ESCC | 1.26e-16 | 1.09e-01 | 0.0926 |
10691 | GMEB1 | P61T-E | Human | Esophagus | ESCC | 3.11e-03 | 7.75e-02 | 0.099 |
10691 | GMEB1 | P62T-E | Human | Esophagus | ESCC | 3.60e-17 | 2.60e-01 | 0.1302 |
10691 | GMEB1 | P74T-E | Human | Esophagus | ESCC | 3.73e-10 | 3.66e-01 | 0.1479 |
10691 | GMEB1 | P75T-E | Human | Esophagus | ESCC | 2.27e-17 | 2.63e-01 | 0.1125 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GMEB1 | SNV | Missense_Mutation | novel | c.164N>G | p.Tyr55Cys | p.Y55C | Q9Y692 | protein_coding | tolerated(0.19) | probably_damaging(0.99) | TCGA-3C-AALJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD |
GMEB1 | SNV | Missense_Mutation | c.206A>T | p.Glu69Val | p.E69V | Q9Y692 | protein_coding | deleterious(0.01) | probably_damaging(0.981) | TCGA-A1-A0SK-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
GMEB1 | SNV | Missense_Mutation | c.1517C>T | p.Ser506Leu | p.S506L | Q9Y692 | protein_coding | tolerated(0.2) | benign(0.013) | TCGA-A8-A07W-01 | Breast | breast invasive carcinoma | Female | >=65 | III/IV | Hormone Therapy | exemestane | SD | |
GMEB1 | SNV | Missense_Mutation | novel | c.1718N>T | p.Asp573Val | p.D573V | Q9Y692 | protein_coding | deleterious_low_confidence(0) | probably_damaging(0.987) | TCGA-AR-A2LN-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | letrozole | SD |
GMEB1 | SNV | Missense_Mutation | novel | c.1330N>G | p.Gln444Glu | p.Q444E | Q9Y692 | protein_coding | deleterious(0.02) | possibly_damaging(0.857) | TCGA-BH-A0E7-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD |
GMEB1 | SNV | Missense_Mutation | c.347T>A | p.Ile116Lys | p.I116K | Q9Y692 | protein_coding | deleterious(0.01) | probably_damaging(0.995) | TCGA-D8-A1JK-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GMEB1 | SNV | Missense_Mutation | c.477N>A | p.Met159Ile | p.M159I | Q9Y692 | protein_coding | tolerated(0.59) | probably_damaging(0.932) | TCGA-E2-A14Z-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | arimidex | PD | |
GMEB1 | SNV | Missense_Mutation | novel | c.1398N>G | p.His466Gln | p.H466Q | Q9Y692 | protein_coding | tolerated(0.09) | probably_damaging(0.969) | TCGA-E2-A1B6-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unspecific | Adriamycin | SD |
GMEB1 | insertion | Frame_Shift_Ins | novel | c.82_83insTC | p.Asp28ValfsTer7 | p.D28Vfs*7 | Q9Y692 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD | ||
GMEB1 | insertion | Frame_Shift_Ins | novel | c.83_84insTCTTCCCCTTCCCATGCAGCTCAGTTCAGTCTCCCTC | p.Thr29LeufsTer14 | p.T29Lfs*14 | Q9Y692 | protein_coding | TCGA-A2-A0D1-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Chemotherapy | taxotere | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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