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Gene: GID4 |
Gene summary for GID4 |
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Gene information | Species | Human | Gene symbol | GID4 | Gene ID | 79018 |
Gene name | GID complex subunit 4 homolog | |
Gene Alias | C17orf39 | |
Cytomap | 17p11.2 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | B3KXL6 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
79018 | GID4 | P30T-E | Human | Esophagus | ESCC | 1.86e-13 | 3.60e-01 | 0.137 |
79018 | GID4 | P31T-E | Human | Esophagus | ESCC | 2.81e-07 | 1.44e-01 | 0.1251 |
79018 | GID4 | P32T-E | Human | Esophagus | ESCC | 1.93e-19 | 4.15e-01 | 0.1666 |
79018 | GID4 | P36T-E | Human | Esophagus | ESCC | 5.06e-13 | 2.40e-01 | 0.1187 |
79018 | GID4 | P37T-E | Human | Esophagus | ESCC | 3.38e-11 | 1.66e-01 | 0.1371 |
79018 | GID4 | P38T-E | Human | Esophagus | ESCC | 2.67e-04 | 2.48e-01 | 0.127 |
79018 | GID4 | P39T-E | Human | Esophagus | ESCC | 4.36e-03 | 5.17e-02 | 0.0894 |
79018 | GID4 | P40T-E | Human | Esophagus | ESCC | 1.11e-03 | 6.71e-02 | 0.109 |
79018 | GID4 | P42T-E | Human | Esophagus | ESCC | 1.84e-04 | 5.71e-02 | 0.1175 |
79018 | GID4 | P44T-E | Human | Esophagus | ESCC | 1.14e-06 | 8.65e-02 | 0.1096 |
79018 | GID4 | P47T-E | Human | Esophagus | ESCC | 1.03e-08 | 8.79e-02 | 0.1067 |
79018 | GID4 | P48T-E | Human | Esophagus | ESCC | 3.27e-07 | 8.09e-02 | 0.0959 |
79018 | GID4 | P49T-E | Human | Esophagus | ESCC | 2.06e-07 | 7.25e-01 | 0.1768 |
79018 | GID4 | P52T-E | Human | Esophagus | ESCC | 1.26e-07 | 9.69e-02 | 0.1555 |
79018 | GID4 | P54T-E | Human | Esophagus | ESCC | 5.38e-07 | 8.68e-02 | 0.0975 |
79018 | GID4 | P57T-E | Human | Esophagus | ESCC | 1.25e-05 | 4.12e-02 | 0.0926 |
79018 | GID4 | P61T-E | Human | Esophagus | ESCC | 1.24e-11 | 1.74e-01 | 0.099 |
79018 | GID4 | P62T-E | Human | Esophagus | ESCC | 4.47e-15 | 1.69e-01 | 0.1302 |
79018 | GID4 | P65T-E | Human | Esophagus | ESCC | 1.25e-05 | 3.14e-02 | 0.0978 |
79018 | GID4 | P74T-E | Human | Esophagus | ESCC | 4.70e-08 | 2.61e-01 | 0.1479 |
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Tissue | Expression Dynamics | Abbreviation |
Esophagus | ![]() | ESCC: Esophageal squamous cell carcinoma |
HGIN: High-grade intraepithelial neoplasias | ||
LGIN: Low-grade intraepithelial neoplasias |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GID4 | SNV | Missense_Mutation | c.353N>T | p.Ala118Val | p.A118V | Q8IVV7 | protein_coding | tolerated(0.26) | benign(0.007) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
GID4 | SNV | Missense_Mutation | c.631T>C | p.Tyr211His | p.Y211H | Q8IVV7 | protein_coding | deleterious(0.03) | probably_damaging(0.987) | TCGA-F4-6570-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GID4 | insertion | Frame_Shift_Ins | novel | c.404_405insG | p.Asn137GlufsTer26 | p.N137Efs*26 | Q8IVV7 | protein_coding | TCGA-A6-A565-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unspecific | 5FU | PD | ||
GID4 | SNV | Missense_Mutation | novel | c.565N>T | p.Arg189Cys | p.R189C | Q8IVV7 | protein_coding | deleterious(0) | probably_damaging(0.999) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
GID4 | SNV | Missense_Mutation | c.632N>G | p.Tyr211Cys | p.Y211C | Q8IVV7 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-AP-A054-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | PD | |
GID4 | SNV | Missense_Mutation | c.827N>A | p.Arg276Lys | p.R276K | Q8IVV7 | protein_coding | tolerated(0.19) | benign(0.137) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GID4 | SNV | Missense_Mutation | rs750112471 | c.442G>A | p.Val148Met | p.V148M | Q8IVV7 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-AP-A0LM-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | cisplatin | SD |
GID4 | SNV | Missense_Mutation | novel | c.493N>G | p.Thr165Ala | p.T165A | Q8IVV7 | protein_coding | deleterious(0.02) | probably_damaging(0.999) | TCGA-AX-A2HJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
GID4 | SNV | Missense_Mutation | novel | c.736A>G | p.Ile246Val | p.I246V | Q8IVV7 | protein_coding | tolerated(0.99) | benign(0.336) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
GID4 | SNV | Missense_Mutation | novel | c.760T>G | p.Phe254Val | p.F254V | Q8IVV7 | protein_coding | deleterious(0) | possibly_damaging(0.905) | TCGA-EO-A22U-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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