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Gene: GADD45B |
Gene summary for GADD45B |
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Gene information | Species | Human | Gene symbol | GADD45B | Gene ID | 4616 |
Gene name | growth arrest and DNA damage inducible beta | |
Gene Alias | GADD45BETA | |
Cytomap | 19p13.3 | |
Gene Type | protein-coding | GO ID | GO:0000165 | UniProtAcc | O75293 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
4616 | GADD45B | GSM4909316 | Human | Breast | IDC | 1.24e-10 | -8.32e-01 | 0.21 |
4616 | GADD45B | GSM4909319 | Human | Breast | IDC | 6.79e-30 | -5.97e-01 | 0.1563 |
4616 | GADD45B | GSM4909321 | Human | Breast | IDC | 1.57e-13 | 3.88e-01 | 0.1559 |
4616 | GADD45B | brca2 | Human | Breast | Precancer | 4.99e-10 | -6.65e-01 | -0.024 |
4616 | GADD45B | brca3 | Human | Breast | Precancer | 4.49e-02 | -2.72e-01 | -0.0263 |
4616 | GADD45B | M1 | Human | Breast | IDC | 6.56e-16 | -8.20e-01 | 0.1577 |
4616 | GADD45B | M2 | Human | Breast | IDC | 3.46e-10 | -9.64e-01 | 0.21 |
4616 | GADD45B | M5 | Human | Breast | IDC | 1.37e-10 | -1.08e+00 | 0.1598 |
4616 | GADD45B | NCCBC11 | Human | Breast | DCIS | 3.13e-05 | -7.58e-01 | 0.1232 |
4616 | GADD45B | NCCBC14 | Human | Breast | DCIS | 8.80e-36 | -9.72e-01 | 0.2021 |
4616 | GADD45B | NCCBC2 | Human | Breast | DCIS | 8.49e-08 | -9.41e-01 | 0.1554 |
4616 | GADD45B | NCCBC3 | Human | Breast | DCIS | 1.66e-37 | -1.02e+00 | 0.1198 |
4616 | GADD45B | NCCBC5 | Human | Breast | DCIS | 1.39e-28 | -8.81e-01 | 0.2046 |
4616 | GADD45B | NCCBC6 | Human | Breast | DCIS | 6.20e-05 | -8.38e-01 | 0.2095 |
4616 | GADD45B | P1 | Human | Breast | IDC | 1.23e-29 | -8.35e-01 | 0.1527 |
4616 | GADD45B | P2 | Human | Breast | IDC | 1.21e-30 | -1.06e+00 | 0.21 |
4616 | GADD45B | DCIS2 | Human | Breast | DCIS | 2.33e-18 | -1.67e-01 | 0.0085 |
4616 | GADD45B | HSIL_HPV_2 | Human | Cervix | HSIL_HPV | 2.84e-10 | -5.32e-01 | 0.0208 |
4616 | GADD45B | CCI_1 | Human | Cervix | CC | 5.88e-09 | -7.68e-01 | 0.528 |
4616 | GADD45B | CCI_2 | Human | Cervix | CC | 1.70e-03 | -6.82e-01 | 0.5249 |
Page: 1 2 3 4 5 6 7 8 9 10 11 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00513489 | Breast | Precancer | negative regulation of transferase activity | 27/1080 | 268/18723 | 3.49e-03 | 2.90e-02 | 27 |
GO:005134814 | Breast | IDC | negative regulation of transferase activity | 39/1434 | 268/18723 | 7.89e-05 | 1.56e-03 | 39 |
GO:00459369 | Breast | IDC | negative regulation of phosphate metabolic process | 53/1434 | 441/18723 | 7.21e-04 | 8.79e-03 | 53 |
GO:00105639 | Breast | IDC | negative regulation of phosphorus metabolic process | 53/1434 | 442/18723 | 7.60e-04 | 9.25e-03 | 53 |
GO:00064699 | Breast | IDC | negative regulation of protein kinase activity | 27/1434 | 212/18723 | 6.30e-03 | 4.47e-02 | 27 |
GO:005134824 | Breast | DCIS | negative regulation of transferase activity | 39/1390 | 268/18723 | 4.02e-05 | 8.60e-04 | 39 |
GO:004593614 | Breast | DCIS | negative regulation of phosphate metabolic process | 53/1390 | 441/18723 | 3.48e-04 | 4.96e-03 | 53 |
GO:001056314 | Breast | DCIS | negative regulation of phosphorus metabolic process | 53/1390 | 442/18723 | 3.68e-04 | 5.18e-03 | 53 |
GO:000646913 | Breast | DCIS | negative regulation of protein kinase activity | 27/1390 | 212/18723 | 4.18e-03 | 3.30e-02 | 27 |
GO:00423269 | Breast | DCIS | negative regulation of phosphorylation | 43/1390 | 385/18723 | 4.78e-03 | 3.62e-02 | 43 |
GO:00019339 | Breast | DCIS | negative regulation of protein phosphorylation | 39/1390 | 342/18723 | 4.94e-03 | 3.71e-02 | 39 |
GO:00336738 | Breast | DCIS | negative regulation of kinase activity | 29/1390 | 237/18723 | 5.44e-03 | 3.99e-02 | 29 |
GO:00310988 | Cervix | CC | stress-activated protein kinase signaling cascade | 58/2311 | 247/18723 | 8.02e-07 | 2.89e-05 | 58 |
GO:005134810 | Cervix | CC | negative regulation of transferase activity | 60/2311 | 268/18723 | 2.77e-06 | 8.02e-05 | 60 |
GO:004593610 | Cervix | CC | negative regulation of phosphate metabolic process | 88/2311 | 441/18723 | 2.92e-06 | 8.27e-05 | 88 |
GO:00514038 | Cervix | CC | stress-activated MAPK cascade | 55/2311 | 239/18723 | 2.96e-06 | 8.31e-05 | 55 |
GO:001056310 | Cervix | CC | negative regulation of phosphorus metabolic process | 88/2311 | 442/18723 | 3.21e-06 | 8.77e-05 | 88 |
GO:00703027 | Cervix | CC | regulation of stress-activated protein kinase signaling cascade | 46/2311 | 195/18723 | 9.35e-06 | 2.11e-04 | 46 |
GO:004232610 | Cervix | CC | negative regulation of phosphorylation | 77/2311 | 385/18723 | 1.09e-05 | 2.38e-04 | 77 |
GO:000193310 | Cervix | CC | negative regulation of protein phosphorylation | 69/2311 | 342/18723 | 2.29e-05 | 4.01e-04 | 69 |
Page: 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa0516918 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa042189 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa042108 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0516919 | Breast | Precancer | Epstein-Barr virus infection | 35/684 | 202/8465 | 1.15e-05 | 1.26e-04 | 9.64e-05 | 35 |
hsa0421814 | Breast | Precancer | Cellular senescence | 29/684 | 156/8465 | 1.66e-05 | 1.69e-04 | 1.30e-04 | 29 |
hsa0421013 | Breast | Precancer | Apoptosis | 25/684 | 136/8465 | 7.61e-05 | 6.87e-04 | 5.26e-04 | 25 |
hsa0516922 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa0421824 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0421022 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa041157 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa052147 | Breast | IDC | Glioma | 16/867 | 75/8465 | 3.30e-03 | 2.10e-02 | 1.57e-02 | 16 |
hsa052109 | Breast | IDC | Colorectal cancer | 17/867 | 86/8465 | 5.70e-03 | 3.13e-02 | 2.34e-02 | 17 |
hsa0522010 | Breast | IDC | Chronic myeloid leukemia | 15/867 | 76/8465 | 9.24e-03 | 4.37e-02 | 3.27e-02 | 15 |
hsa052169 | Breast | IDC | Thyroid cancer | 9/867 | 37/8465 | 1.06e-02 | 4.92e-02 | 3.68e-02 | 9 |
hsa0516932 | Breast | IDC | Epstein-Barr virus infection | 45/867 | 202/8465 | 3.16e-07 | 6.05e-06 | 4.52e-06 | 45 |
hsa0421834 | Breast | IDC | Cellular senescence | 35/867 | 156/8465 | 5.49e-06 | 7.43e-05 | 5.56e-05 | 35 |
hsa0421032 | Breast | IDC | Apoptosis | 31/867 | 136/8465 | 1.34e-05 | 1.61e-04 | 1.20e-04 | 31 |
hsa0411512 | Breast | IDC | p53 signaling pathway | 16/867 | 74/8465 | 2.86e-03 | 1.86e-02 | 1.39e-02 | 16 |
hsa0521413 | Breast | IDC | Glioma | 16/867 | 75/8465 | 3.30e-03 | 2.10e-02 | 1.57e-02 | 16 |
hsa0521014 | Breast | IDC | Colorectal cancer | 17/867 | 86/8465 | 5.70e-03 | 3.13e-02 | 2.34e-02 | 17 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
GADD45B | SNV | Missense_Mutation | c.103N>T | p.Arg35Cys | p.R35C | O75293 | protein_coding | tolerated(0.66) | benign(0.003) | TCGA-DS-A0VK-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | carboplatin | PD | |
GADD45B | SNV | Missense_Mutation | c.187N>A | p.Glu63Lys | p.E63K | O75293 | protein_coding | tolerated(0.07) | benign(0.102) | TCGA-93-A4JP-01 | Lung | lung adenocarcinoma | Male | <65 | III/IV | Chemotherapy | carboplatin | PD | |
GADD45B | SNV | Missense_Mutation | c.376N>T | p.His126Tyr | p.H126Y | O75293 | protein_coding | tolerated(0.53) | benign(0.057) | TCGA-34-5929-01 | Lung | lung squamous cell carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
GADD45B | SNV | Missense_Mutation | c.189N>C | p.Glu63Asp | p.E63D | O75293 | protein_coding | tolerated(0.1) | benign(0.015) | TCGA-D7-A4YY-01 | Stomach | stomach adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5-fluorouracil | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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