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Gene: FOSL2 |
Gene summary for FOSL2 |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FOSL2 | Gene ID | 2355 |
| Gene name | FOS like 2, AP-1 transcription factor subunit | |
| Gene Alias | FRA2 | |
| Cytomap | 2p23.2 | |
| Gene Type | protein-coding | GO ID | GO:0002064 | UniProtAcc | P15408 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 2355 | FOSL2 | P20T-E | Human | Esophagus | ESCC | 5.71e-12 | 5.54e-01 | 0.1124 |
| 2355 | FOSL2 | P21T-E | Human | Esophagus | ESCC | 1.79e-12 | 1.70e-01 | 0.1617 |
| 2355 | FOSL2 | P22T-E | Human | Esophagus | ESCC | 1.29e-11 | 1.02e-01 | 0.1236 |
| 2355 | FOSL2 | P23T-E | Human | Esophagus | ESCC | 1.05e-16 | 7.59e-01 | 0.108 |
| 2355 | FOSL2 | P24T-E | Human | Esophagus | ESCC | 4.95e-08 | 6.73e-02 | 0.1287 |
| 2355 | FOSL2 | P26T-E | Human | Esophagus | ESCC | 5.95e-24 | 5.39e-01 | 0.1276 |
| 2355 | FOSL2 | P27T-E | Human | Esophagus | ESCC | 4.30e-15 | 4.23e-01 | 0.1055 |
| 2355 | FOSL2 | P28T-E | Human | Esophagus | ESCC | 1.68e-50 | 1.41e+00 | 0.1149 |
| 2355 | FOSL2 | P30T-E | Human | Esophagus | ESCC | 1.03e-16 | 1.27e+00 | 0.137 |
| 2355 | FOSL2 | P31T-E | Human | Esophagus | ESCC | 9.62e-17 | 3.21e-01 | 0.1251 |
| 2355 | FOSL2 | P32T-E | Human | Esophagus | ESCC | 1.43e-11 | 2.78e-01 | 0.1666 |
| 2355 | FOSL2 | P36T-E | Human | Esophagus | ESCC | 6.74e-10 | 4.17e-01 | 0.1187 |
| 2355 | FOSL2 | P37T-E | Human | Esophagus | ESCC | 1.65e-12 | 2.49e-01 | 0.1371 |
| 2355 | FOSL2 | P39T-E | Human | Esophagus | ESCC | 3.44e-22 | 5.66e-01 | 0.0894 |
| 2355 | FOSL2 | P40T-E | Human | Esophagus | ESCC | 1.28e-09 | 3.33e-01 | 0.109 |
| 2355 | FOSL2 | P42T-E | Human | Esophagus | ESCC | 3.90e-11 | 5.92e-01 | 0.1175 |
| 2355 | FOSL2 | P44T-E | Human | Esophagus | ESCC | 8.62e-12 | 4.52e-02 | 0.1096 |
| 2355 | FOSL2 | P47T-E | Human | Esophagus | ESCC | 6.67e-25 | 5.93e-01 | 0.1067 |
| 2355 | FOSL2 | P48T-E | Human | Esophagus | ESCC | 1.00e-15 | 4.79e-01 | 0.0959 |
| 2355 | FOSL2 | P49T-E | Human | Esophagus | ESCC | 2.39e-08 | 1.61e+00 | 0.1768 |
| Page: 1 2 3 4 5 6 |
| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease | ||
| Oral Cavity |  | EOLP: Erosive Oral lichen planus |
| LP: leukoplakia | ||
| NEOLP: Non-erosive oral lichen planus | ||
| OSCC: Oral squamous cell carcinoma | ||
| Skin |  | AK: Actinic keratosis |
| cSCC: Cutaneous squamous cell carcinoma | ||
| SCCIS:squamous cell carcinoma in situ | ||
| Thyroid |  | ATC: Anaplastic thyroid cancer |
| HT: Hashimoto's thyroiditis | ||
| PTC: Papillary thyroid cancer |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| GO:00481458 | Esophagus | HGIN | regulation of fibroblast proliferation | 23/2587 | 80/18723 | 3.71e-04 | 5.77e-03 | 23 |
| GO:00481447 | Esophagus | HGIN | fibroblast proliferation | 23/2587 | 81/18723 | 4.52e-04 | 6.62e-03 | 23 |
| GO:00435888 | Esophagus | ESCC | skin development | 163/8552 | 263/18723 | 6.48e-08 | 1.14e-06 | 163 |
| GO:000854410 | Esophagus | ESCC | epidermis development | 193/8552 | 324/18723 | 2.87e-07 | 4.19e-06 | 193 |
| GO:000206420 | Esophagus | ESCC | epithelial cell development | 136/8552 | 220/18723 | 9.50e-07 | 1.21e-05 | 136 |
| GO:004814414 | Esophagus | ESCC | fibroblast proliferation | 57/8552 | 81/18723 | 5.83e-06 | 6.03e-05 | 57 |
| GO:004814514 | Esophagus | ESCC | regulation of fibroblast proliferation | 56/8552 | 80/18723 | 9.08e-06 | 8.71e-05 | 56 |
| GO:000991310 | Esophagus | ESCC | epidermal cell differentiation | 122/8552 | 202/18723 | 1.69e-05 | 1.51e-04 | 122 |
| GO:00302167 | Esophagus | ESCC | keratinocyte differentiation | 86/8552 | 139/18723 | 8.53e-05 | 6.19e-04 | 86 |
| GO:00481464 | Esophagus | ESCC | positive regulation of fibroblast proliferation | 32/8552 | 48/18723 | 2.70e-03 | 1.14e-02 | 32 |
| GO:000206412 | Liver | Cirrhotic | epithelial cell development | 80/4634 | 220/18723 | 7.63e-05 | 8.44e-04 | 80 |
| GO:0048145 | Liver | Cirrhotic | regulation of fibroblast proliferation | 33/4634 | 80/18723 | 8.46e-04 | 6.12e-03 | 33 |
| GO:0048144 | Liver | Cirrhotic | fibroblast proliferation | 33/4634 | 81/18723 | 1.09e-03 | 7.59e-03 | 33 |
| GO:0048146 | Liver | Cirrhotic | positive regulation of fibroblast proliferation | 20/4634 | 48/18723 | 7.37e-03 | 3.52e-02 | 20 |
| GO:000206422 | Liver | HCC | epithelial cell development | 114/7958 | 220/18723 | 3.19e-03 | 1.47e-02 | 114 |
| GO:00435887 | Oral cavity | OSCC | skin development | 143/7305 | 263/18723 | 2.77e-07 | 4.27e-06 | 143 |
| GO:00085449 | Oral cavity | OSCC | epidermis development | 171/7305 | 324/18723 | 2.89e-07 | 4.43e-06 | 171 |
| GO:00302166 | Oral cavity | OSCC | keratinocyte differentiation | 81/7305 | 139/18723 | 3.16e-06 | 3.81e-05 | 81 |
| GO:00099139 | Oral cavity | OSCC | epidermal cell differentiation | 109/7305 | 202/18723 | 1.08e-05 | 1.14e-04 | 109 |
| GO:000206419 | Oral cavity | OSCC | epithelial cell development | 116/7305 | 220/18723 | 2.34e-05 | 2.21e-04 | 116 |
| Page: 1 2 3 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| hsa043806 | Oral cavity | OSCC | Osteoclast differentiation | 73/3704 | 128/8465 | 1.60e-03 | 4.44e-03 | 2.26e-03 | 73 |
| hsa0438011 | Oral cavity | OSCC | Osteoclast differentiation | 73/3704 | 128/8465 | 1.60e-03 | 4.44e-03 | 2.26e-03 | 73 |
| hsa043802 | Oral cavity | EOLP | Osteoclast differentiation | 44/1218 | 128/8465 | 8.92e-09 | 1.37e-07 | 8.10e-08 | 44 |
| hsa043803 | Oral cavity | EOLP | Osteoclast differentiation | 44/1218 | 128/8465 | 8.92e-09 | 1.37e-07 | 8.10e-08 | 44 |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| FOSL2 | MES | Cervix | CC | SLC2A1,WSB1,BHLHE40, etc. | 7.00e-01 |  |
| FOSL2 | MES | Cervix | HSIL_HPV | SLC2A1,WSB1,BHLHE40, etc. | 4.60e-01 |  |
| FOSL2 | IMENT | Colorectum | AD | AQP8,PDK4,PLAAT2, etc. | 1.69e-01 |  |
| FOSL2 | IMENT | Colorectum | SER | AQP8,PDK4,PLAAT2, etc. | 1.96e-01 |  |
| FOSL2 | PANIN | Pancreas | Healthy | UGCG,CCL14,PTPN1, etc. | 2.34e-01 |  |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FOSL2 | SNV | Missense_Mutation | novel | c.128C>T | p.Ser43Leu | p.S43L | P15408 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| FOSL2 | SNV | Missense_Mutation | c.439N>C | p.Glu147Gln | p.E147Q | P15408 | protein_coding | deleterious(0) | probably_damaging(0.99) | TCGA-E2-A15L-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
| FOSL2 | insertion | Frame_Shift_Ins | novel | c.911_912insGCAATCT | p.His304GlnfsTer8 | p.H304Qfs*8 | P15408 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
| FOSL2 | SNV | Missense_Mutation | novel | c.534G>T | p.Glu178Asp | p.E178D | P15408 | protein_coding | tolerated(0.16) | benign(0.018) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
| FOSL2 | SNV | Missense_Mutation | c.58N>G | p.Pro20Ala | p.P20A | P15408 | protein_coding | deleterious(0.01) | possibly_damaging(0.757) | TCGA-EK-A2RJ-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Unknown | Unknown | SD | |
| FOSL2 | SNV | Missense_Mutation | rs143327177 | c.596N>A | p.Arg199Gln | p.R199Q | P15408 | protein_coding | tolerated(0.65) | benign(0.003) | TCGA-AZ-4315-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| FOSL2 | SNV | Missense_Mutation | rs199613963 | c.248N>T | p.Ser83Ile | p.S83I | P15408 | protein_coding | deleterious(0.03) | possibly_damaging(0.758) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
| FOSL2 | SNV | Missense_Mutation | novel | c.908N>T | p.Ala303Val | p.A303V | P15408 | protein_coding | tolerated(0.06) | probably_damaging(0.986) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
| FOSL2 | SNV | Missense_Mutation | novel | c.331N>T | p.Gly111Cys | p.G111C | P15408 | protein_coding | deleterious(0.01) | probably_damaging(0.927) | TCGA-AJ-A3OJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | carboplatin | CR |
| FOSL2 | SNV | Missense_Mutation | c.383G>A | p.Arg128His | p.R128H | P15408 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AP-A059-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
| Page: 1 2 3 4 5 |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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