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Gene: FKBP3 |
Gene summary for FKBP3 |
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Gene information | Species | Human | Gene symbol | FKBP3 | Gene ID | 2287 |
Gene name | FKBP prolyl isomerase 3 | |
Gene Alias | FKBP-25 | |
Cytomap | 14q21.2 | |
Gene Type | protein-coding | GO ID | GO:0000413 | UniProtAcc | Q00688 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2287 | FKBP3 | LZE4T | Human | Esophagus | ESCC | 2.14e-25 | 9.29e-01 | 0.0811 |
2287 | FKBP3 | LZE5T | Human | Esophagus | ESCC | 2.65e-09 | 1.12e+00 | 0.0514 |
2287 | FKBP3 | LZE7T | Human | Esophagus | ESCC | 1.07e-10 | 5.72e-01 | 0.0667 |
2287 | FKBP3 | LZE8T | Human | Esophagus | ESCC | 2.30e-14 | 4.16e-01 | 0.067 |
2287 | FKBP3 | LZE20T | Human | Esophagus | ESCC | 2.97e-16 | 7.34e-01 | 0.0662 |
2287 | FKBP3 | LZE22T | Human | Esophagus | ESCC | 4.36e-07 | 1.13e+00 | 0.068 |
2287 | FKBP3 | LZE24T | Human | Esophagus | ESCC | 1.32e-21 | 6.44e-01 | 0.0596 |
2287 | FKBP3 | LZE21T | Human | Esophagus | ESCC | 3.91e-03 | 5.57e-01 | 0.0655 |
2287 | FKBP3 | LZE6T | Human | Esophagus | ESCC | 6.20e-11 | 7.70e-01 | 0.0845 |
2287 | FKBP3 | P1T-E | Human | Esophagus | ESCC | 1.57e-11 | 5.61e-01 | 0.0875 |
2287 | FKBP3 | P2T-E | Human | Esophagus | ESCC | 3.98e-41 | 9.51e-01 | 0.1177 |
2287 | FKBP3 | P4T-E | Human | Esophagus | ESCC | 6.07e-56 | 1.23e+00 | 0.1323 |
2287 | FKBP3 | P5T-E | Human | Esophagus | ESCC | 1.06e-76 | 1.65e+00 | 0.1327 |
2287 | FKBP3 | P8T-E | Human | Esophagus | ESCC | 7.39e-50 | 1.15e+00 | 0.0889 |
2287 | FKBP3 | P9T-E | Human | Esophagus | ESCC | 4.81e-33 | 8.64e-01 | 0.1131 |
2287 | FKBP3 | P10T-E | Human | Esophagus | ESCC | 3.93e-66 | 1.38e+00 | 0.116 |
2287 | FKBP3 | P11T-E | Human | Esophagus | ESCC | 7.83e-20 | 9.91e-01 | 0.1426 |
2287 | FKBP3 | P12T-E | Human | Esophagus | ESCC | 3.85e-74 | 1.75e+00 | 0.1122 |
2287 | FKBP3 | P15T-E | Human | Esophagus | ESCC | 1.54e-71 | 1.81e+00 | 0.1149 |
2287 | FKBP3 | P16T-E | Human | Esophagus | ESCC | 1.08e-32 | 5.74e-01 | 0.1153 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00004133 | Endometrium | AEH | protein peptidyl-prolyl isomerization | 13/2100 | 42/18723 | 4.74e-04 | 4.91e-03 | 13 |
GO:00182086 | Endometrium | AEH | peptidyl-proline modification | 16/2100 | 58/18723 | 4.75e-04 | 4.91e-03 | 16 |
GO:000041311 | Endometrium | EEC | protein peptidyl-prolyl isomerization | 14/2168 | 42/18723 | 1.69e-04 | 2.10e-03 | 14 |
GO:001820813 | Endometrium | EEC | peptidyl-proline modification | 17/2168 | 58/18723 | 2.11e-04 | 2.54e-03 | 17 |
GO:001820816 | Esophagus | ESCC | peptidyl-proline modification | 46/8552 | 58/18723 | 1.59e-07 | 2.51e-06 | 46 |
GO:000041313 | Esophagus | ESCC | protein peptidyl-prolyl isomerization | 32/8552 | 42/18723 | 5.52e-05 | 4.27e-04 | 32 |
GO:00182084 | Liver | Cirrhotic | peptidyl-proline modification | 26/4634 | 58/18723 | 6.65e-04 | 5.04e-03 | 26 |
GO:00004132 | Liver | Cirrhotic | protein peptidyl-prolyl isomerization | 19/4634 | 42/18723 | 3.00e-03 | 1.71e-02 | 19 |
GO:001820811 | Liver | HCC | peptidyl-proline modification | 42/7958 | 58/18723 | 3.73e-06 | 4.85e-05 | 42 |
GO:00004131 | Liver | HCC | protein peptidyl-prolyl isomerization | 31/7958 | 42/18723 | 3.83e-05 | 3.80e-04 | 31 |
GO:00182088 | Oral cavity | OSCC | peptidyl-proline modification | 42/7305 | 58/18723 | 2.49e-07 | 3.92e-06 | 42 |
GO:00004134 | Oral cavity | OSCC | protein peptidyl-prolyl isomerization | 28/7305 | 42/18723 | 2.61e-04 | 1.67e-03 | 28 |
GO:001820815 | Oral cavity | LP | peptidyl-proline modification | 28/4623 | 58/18723 | 8.35e-05 | 1.07e-03 | 28 |
GO:000041312 | Oral cavity | LP | protein peptidyl-prolyl isomerization | 22/4623 | 42/18723 | 1.04e-04 | 1.26e-03 | 22 |
GO:00182087 | Prostate | BPH | peptidyl-proline modification | 18/3107 | 58/18723 | 4.75e-03 | 2.27e-02 | 18 |
GO:001820814 | Prostate | Tumor | peptidyl-proline modification | 18/3246 | 58/18723 | 7.57e-03 | 3.37e-02 | 18 |
GO:001820810 | Skin | cSCC | peptidyl-proline modification | 37/4864 | 58/18723 | 1.53e-09 | 5.82e-08 | 37 |
GO:00004136 | Skin | cSCC | protein peptidyl-prolyl isomerization | 26/4864 | 42/18723 | 9.92e-07 | 1.78e-05 | 26 |
GO:001820817 | Thyroid | PTC | peptidyl-proline modification | 42/5968 | 58/18723 | 2.71e-10 | 8.91e-09 | 42 |
GO:00004137 | Thyroid | PTC | protein peptidyl-prolyl isomerization | 30/5968 | 42/18723 | 1.65e-07 | 3.13e-06 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FKBP3 | SNV | Missense_Mutation | c.259A>C | p.Asn87His | p.N87H | Q00688 | protein_coding | deleterious(0.05) | benign(0.078) | TCGA-D8-A1JG-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | doxorubicin | SD | |
FKBP3 | SNV | Missense_Mutation | c.79N>G | p.Lys27Glu | p.K27E | Q00688 | protein_coding | tolerated(0.26) | benign(0.018) | TCGA-CM-4743-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Chemotherapy | capecitabine | SD | |
FKBP3 | SNV | Missense_Mutation | c.479N>G | p.Lys160Arg | p.K160R | Q00688 | protein_coding | tolerated(0.14) | benign(0.301) | TCGA-G4-6304-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Chemotherapy | fluorouracil | PD | |
FKBP3 | SNV | Missense_Mutation | novel | c.341C>A | p.Ser114Tyr | p.S114Y | Q00688 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FKBP3 | SNV | Missense_Mutation | novel | c.112C>A | p.Leu38Ile | p.L38I | Q00688 | protein_coding | deleterious(0) | probably_damaging(0.994) | TCGA-EI-6917-01 | Colorectum | rectum adenocarcinoma | Male | <65 | III/IV | Chemotherapy | 5fluorouracil+oxaciplatina+l-folinian | SD |
FKBP3 | SNV | Missense_Mutation | novel | c.644C>A | p.Thr215Asn | p.T215N | Q00688 | protein_coding | deleterious(0.03) | benign(0.001) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FKBP3 | SNV | Missense_Mutation | rs760527701 | c.211N>T | p.Arg71Cys | p.R71C | Q00688 | protein_coding | deleterious(0.02) | benign(0.007) | TCGA-AX-A2HD-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FKBP3 | SNV | Missense_Mutation | novel | c.403N>C | p.Tyr135His | p.Y135H | Q00688 | protein_coding | deleterious(0.02) | benign(0.262) | TCGA-B5-A1MR-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FKBP3 | SNV | Missense_Mutation | c.4N>A | p.Ala2Thr | p.A2T | Q00688 | protein_coding | deleterious_low_confidence(0) | benign(0.053) | TCGA-D1-A176-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FKBP3 | SNV | Missense_Mutation | novel | c.341N>T | p.Ser114Phe | p.S114F | Q00688 | protein_coding | deleterious(0) | possibly_damaging(0.646) | TCGA-EO-A22X-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unspecific | Carboplatin | Complete Response |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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