![]() |
|||||
|
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() | |
![]() |
Gene: FBXO6 |
Gene summary for FBXO6 |
![]() |
Gene information | Species | Human | Gene symbol | FBXO6 | Gene ID | 26270 |
Gene name | F-box protein 6 | |
Gene Alias | FBG2 | |
Cytomap | 1p36.22 | |
Gene Type | protein-coding | GO ID | GO:0000075 | UniProtAcc | Q9NRD1 |
Top |
Malignant transformation analysis |
![]() |
![]() |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26270 | FBXO6 | P27T-E | Human | Esophagus | ESCC | 3.45e-10 | 2.32e-01 | 0.1055 |
26270 | FBXO6 | P28T-E | Human | Esophagus | ESCC | 7.76e-19 | 3.82e-01 | 0.1149 |
26270 | FBXO6 | P30T-E | Human | Esophagus | ESCC | 1.87e-03 | 1.87e-01 | 0.137 |
26270 | FBXO6 | P31T-E | Human | Esophagus | ESCC | 1.09e-14 | 3.18e-01 | 0.1251 |
26270 | FBXO6 | P36T-E | Human | Esophagus | ESCC | 4.29e-12 | 4.20e-01 | 0.1187 |
26270 | FBXO6 | P37T-E | Human | Esophagus | ESCC | 1.59e-07 | 1.71e-01 | 0.1371 |
26270 | FBXO6 | P38T-E | Human | Esophagus | ESCC | 1.26e-07 | 3.04e-01 | 0.127 |
26270 | FBXO6 | P40T-E | Human | Esophagus | ESCC | 1.58e-10 | 4.12e-01 | 0.109 |
26270 | FBXO6 | P42T-E | Human | Esophagus | ESCC | 5.59e-05 | 1.15e-01 | 0.1175 |
26270 | FBXO6 | P47T-E | Human | Esophagus | ESCC | 1.52e-05 | 1.24e-01 | 0.1067 |
26270 | FBXO6 | P48T-E | Human | Esophagus | ESCC | 1.62e-08 | 2.02e-01 | 0.0959 |
26270 | FBXO6 | P52T-E | Human | Esophagus | ESCC | 2.73e-18 | 4.53e-01 | 0.1555 |
26270 | FBXO6 | P54T-E | Human | Esophagus | ESCC | 7.90e-04 | 1.89e-01 | 0.0975 |
26270 | FBXO6 | P56T-E | Human | Esophagus | ESCC | 1.79e-03 | 7.40e-01 | 0.1613 |
26270 | FBXO6 | P57T-E | Human | Esophagus | ESCC | 7.26e-08 | 2.01e-01 | 0.0926 |
26270 | FBXO6 | P61T-E | Human | Esophagus | ESCC | 1.05e-10 | 2.10e-01 | 0.099 |
26270 | FBXO6 | P62T-E | Human | Esophagus | ESCC | 5.45e-15 | 3.58e-01 | 0.1302 |
26270 | FBXO6 | P65T-E | Human | Esophagus | ESCC | 2.08e-07 | 1.27e-01 | 0.0978 |
26270 | FBXO6 | P74T-E | Human | Esophagus | ESCC | 6.16e-18 | 4.72e-01 | 0.1479 |
26270 | FBXO6 | P75T-E | Human | Esophagus | ESCC | 1.18e-49 | 1.06e+00 | 0.1125 |
Page: 1 2 3 4 |
![]() |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
Top |
Malignant transformation related pathway analysis |
![]() |
![]() |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
![]() |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0010498111 | Esophagus | ESCC | proteasomal protein catabolic process | 369/8552 | 490/18723 | 1.13e-41 | 1.80e-38 | 369 |
GO:0043161111 | Esophagus | ESCC | proteasome-mediated ubiquitin-dependent protein catabolic process | 312/8552 | 412/18723 | 3.53e-36 | 4.48e-33 | 312 |
GO:0034976111 | Esophagus | ESCC | response to endoplasmic reticulum stress | 192/8552 | 256/18723 | 7.15e-22 | 1.30e-19 | 192 |
GO:0035966111 | Esophagus | ESCC | response to topologically incorrect protein | 125/8552 | 159/18723 | 1.44e-17 | 1.27e-15 | 125 |
GO:0006986111 | Esophagus | ESCC | response to unfolded protein | 107/8552 | 137/18723 | 7.01e-15 | 3.87e-13 | 107 |
GO:190198713 | Esophagus | ESCC | regulation of cell cycle phase transition | 242/8552 | 390/18723 | 3.86e-11 | 1.26e-09 | 242 |
GO:003650315 | Esophagus | ESCC | ERAD pathway | 82/8552 | 107/18723 | 5.80e-11 | 1.84e-09 | 82 |
GO:00457865 | Esophagus | ESCC | negative regulation of cell cycle | 236/8552 | 385/18723 | 3.62e-10 | 9.93e-09 | 236 |
GO:00000754 | Esophagus | ESCC | cell cycle checkpoint | 117/8552 | 169/18723 | 4.47e-10 | 1.17e-08 | 117 |
GO:003043314 | Esophagus | ESCC | ubiquitin-dependent ERAD pathway | 66/8552 | 85/18723 | 1.64e-09 | 3.78e-08 | 66 |
GO:004277014 | Esophagus | ESCC | signal transduction in response to DNA damage | 117/8552 | 172/18723 | 2.38e-09 | 5.32e-08 | 117 |
GO:00091002 | Esophagus | ESCC | glycoprotein metabolic process | 226/8552 | 387/18723 | 2.64e-07 | 3.94e-06 | 226 |
GO:00109484 | Esophagus | ESCC | negative regulation of cell cycle process | 177/8552 | 294/18723 | 3.26e-07 | 4.59e-06 | 177 |
GO:00315705 | Esophagus | ESCC | DNA integrity checkpoint | 83/8552 | 123/18723 | 8.17e-07 | 1.06e-05 | 83 |
GO:00000775 | Esophagus | ESCC | DNA damage checkpoint | 78/8552 | 115/18723 | 1.27e-06 | 1.56e-05 | 78 |
GO:19019883 | Esophagus | ESCC | negative regulation of cell cycle phase transition | 151/8552 | 249/18723 | 1.28e-06 | 1.57e-05 | 151 |
GO:19011362 | Esophagus | ESCC | carbohydrate derivative catabolic process | 99/8552 | 172/18723 | 1.11e-03 | 5.54e-03 | 99 |
GO:00311461 | Esophagus | ESCC | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process | 33/8552 | 49/18723 | 1.80e-03 | 8.26e-03 | 33 |
GO:0006516 | Esophagus | ESCC | glycoprotein catabolic process | 19/8552 | 28/18723 | 1.49e-02 | 4.84e-02 | 19 |
GO:001049822 | Liver | HCC | proteasomal protein catabolic process | 351/7958 | 490/18723 | 6.92e-40 | 1.46e-36 | 351 |
Page: 1 2 3 |
![]() |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa04141211 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa04141310 | Esophagus | ESCC | Protein processing in endoplasmic reticulum | 147/4205 | 174/8465 | 3.29e-22 | 1.10e-19 | 5.64e-20 | 147 |
hsa0414122 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414132 | Liver | HCC | Protein processing in endoplasmic reticulum | 146/4020 | 174/8465 | 7.34e-24 | 2.46e-21 | 1.37e-21 | 146 |
hsa0414130 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
hsa04141113 | Oral cavity | OSCC | Protein processing in endoplasmic reticulum | 143/3704 | 174/8465 | 6.82e-26 | 2.28e-23 | 1.16e-23 | 143 |
Page: 1 |
Top |
Cell-cell communication analysis |
![]() |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
Page: 1 |
Top |
Single-cell gene regulatory network inference analysis |
![]() |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
Page: 1 |
Top |
Somatic mutation of malignant transformation related genes |
![]() |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO6 | SNV | Missense_Mutation | novel | c.797C>T | p.Ala266Val | p.A266V | Q9NRD1 | protein_coding | deleterious_low_confidence(0.05) | benign(0.003) | TCGA-AN-A0FN-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | rs746354058 | c.88N>A | p.Ala30Thr | p.A30T | Q9NRD1 | protein_coding | deleterious(0.01) | probably_damaging(0.994) | TCGA-AA-3663-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | rs566510540 | c.412G>A | p.Glu138Lys | p.E138K | Q9NRD1 | protein_coding | tolerated(0.29) | benign(0.086) | TCGA-AZ-6601-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | PD |
FBXO6 | SNV | Missense_Mutation | c.512T>C | p.Phe171Ser | p.F171S | Q9NRD1 | protein_coding | deleterious(0) | possibly_damaging(0.787) | TCGA-CM-5861-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FBXO6 | SNV | Missense_Mutation | c.167G>A | p.Arg56His | p.R56H | Q9NRD1 | protein_coding | tolerated(0.11) | benign(0.189) | TCGA-AG-3892-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FBXO6 | SNV | Missense_Mutation | novel | c.265N>A | p.Leu89Met | p.L89M | Q9NRD1 | protein_coding | deleterious(0.01) | probably_damaging(0.996) | TCGA-A5-A0G1-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | novel | c.683N>A | p.Arg228His | p.R228H | Q9NRD1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A0G2-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | rs200760899 | c.682C>T | p.Arg228Cys | p.R228C | Q9NRD1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A1OF-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | novel | c.133N>T | p.Arg45Trp | p.R45W | Q9NRD1 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-A5-A7WJ-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO6 | SNV | Missense_Mutation | c.715N>G | p.Thr239Ala | p.T239A | Q9NRD1 | protein_coding | deleterious(0.03) | probably_damaging(0.958) | TCGA-AX-A063-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
Page: 1 2 3 |
Top |
Related drugs of malignant transformation related genes |
![]() |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
Page: 1 |