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Gene: FBXO32 |
Gene summary for FBXO32 |
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Gene information | Species | Human | Gene symbol | FBXO32 | Gene ID | 114907 |
Gene name | F-box protein 32 | |
Gene Alias | Fbx32 | |
Cytomap | 8q24.13 | |
Gene Type | protein-coding | GO ID | GO:0003008 | UniProtAcc | Q969P5 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
114907 | FBXO32 | brca3 | Human | Breast | Precancer | 1.45e-03 | 1.85e-01 | -0.0263 |
114907 | FBXO32 | M1 | Human | Breast | IDC | 7.45e-12 | -5.34e-01 | 0.1577 |
114907 | FBXO32 | NCCBC14 | Human | Breast | DCIS | 1.42e-17 | -4.70e-01 | 0.2021 |
114907 | FBXO32 | NCCBC2 | Human | Breast | DCIS | 4.41e-04 | -5.62e-01 | 0.1554 |
114907 | FBXO32 | NCCBC3 | Human | Breast | DCIS | 1.90e-06 | -4.59e-01 | 0.1198 |
114907 | FBXO32 | NCCBC5 | Human | Breast | DCIS | 6.44e-14 | -4.55e-01 | 0.2046 |
114907 | FBXO32 | P1 | Human | Breast | IDC | 7.59e-20 | -5.30e-01 | 0.1527 |
114907 | FBXO32 | P2 | Human | Breast | IDC | 3.05e-09 | -4.84e-01 | 0.21 |
114907 | FBXO32 | DCIS2 | Human | Breast | DCIS | 2.00e-17 | 3.48e-01 | 0.0085 |
114907 | FBXO32 | HTA11_2487_2000001011 | Human | Colorectum | SER | 4.36e-02 | 3.01e-01 | -0.1808 |
114907 | FBXO32 | HTA11_1938_2000001011 | Human | Colorectum | AD | 3.08e-02 | 2.55e-01 | -0.0811 |
114907 | FBXO32 | HTA11_78_2000001011 | Human | Colorectum | AD | 2.23e-02 | 2.70e-01 | -0.1088 |
114907 | FBXO32 | HTA11_347_2000001011 | Human | Colorectum | AD | 2.08e-07 | 4.52e-01 | -0.1954 |
114907 | FBXO32 | HTA11_411_2000001011 | Human | Colorectum | SER | 1.31e-03 | 1.36e+00 | -0.2602 |
114907 | FBXO32 | HTA11_2112_2000001011 | Human | Colorectum | SER | 1.29e-03 | 1.14e+00 | -0.2196 |
114907 | FBXO32 | HTA11_1391_2000001011 | Human | Colorectum | AD | 3.09e-02 | 2.68e-01 | -0.059 |
114907 | FBXO32 | HTA11_8622_2000001021 | Human | Colorectum | SER | 2.89e-03 | 2.56e-01 | 0.0528 |
114907 | FBXO32 | HTA11_99999965104_69814 | Human | Colorectum | MSS | 2.25e-05 | 2.81e-01 | 0.281 |
114907 | FBXO32 | HTA11_99999971662_82457 | Human | Colorectum | MSS | 2.41e-05 | 3.80e-01 | 0.3859 |
114907 | FBXO32 | A015-C-005 | Human | Colorectum | FAP | 4.38e-03 | 3.98e-01 | -0.0336 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:00713846 | Breast | Precancer | cellular response to corticosteroid stimulus | 11/1080 | 61/18723 | 6.54e-04 | 8.01e-03 | 11 |
GO:00713856 | Breast | Precancer | cellular response to glucocorticoid stimulus | 10/1080 | 56/18723 | 1.23e-03 | 1.32e-02 | 10 |
GO:19016549 | Breast | Precancer | response to ketone | 22/1080 | 194/18723 | 1.89e-03 | 1.84e-02 | 22 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
GO:003196013 | Breast | IDC | response to corticosteroid | 37/1434 | 167/18723 | 3.10e-09 | 2.63e-07 | 37 |
GO:005138413 | Breast | IDC | response to glucocorticoid | 32/1434 | 148/18723 | 6.52e-08 | 4.07e-06 | 32 |
GO:007138314 | Breast | IDC | cellular response to steroid hormone stimulus | 35/1434 | 204/18723 | 5.29e-06 | 1.75e-04 | 35 |
GO:190165414 | Breast | IDC | response to ketone | 33/1434 | 194/18723 | 1.17e-05 | 3.13e-04 | 33 |
GO:007138413 | Breast | IDC | cellular response to corticosteroid stimulus | 12/1434 | 61/18723 | 2.01e-03 | 1.90e-02 | 12 |
GO:007138513 | Breast | IDC | cellular response to glucocorticoid stimulus | 11/1434 | 56/18723 | 3.08e-03 | 2.61e-02 | 11 |
GO:00030125 | Breast | IDC | muscle system process | 50/1434 | 452/18723 | 5.52e-03 | 4.05e-02 | 50 |
GO:004854524 | Breast | DCIS | response to steroid hormone | 67/1390 | 339/18723 | 1.02e-13 | 2.76e-11 | 67 |
GO:003196022 | Breast | DCIS | response to corticosteroid | 35/1390 | 167/18723 | 1.69e-08 | 1.18e-06 | 35 |
GO:005138422 | Breast | DCIS | response to glucocorticoid | 31/1390 | 148/18723 | 1.11e-07 | 5.93e-06 | 31 |
GO:007138324 | Breast | DCIS | cellular response to steroid hormone stimulus | 34/1390 | 204/18723 | 7.04e-06 | 1.95e-04 | 34 |
GO:190165423 | Breast | DCIS | response to ketone | 30/1390 | 194/18723 | 9.98e-05 | 1.82e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
hsa040689 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa0406814 | Esophagus | ESCC | FoxO signaling pathway | 89/4205 | 131/8465 | 1.56e-05 | 7.98e-05 | 4.09e-05 | 89 |
hsa040684 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa040685 | Liver | HCC | FoxO signaling pathway | 85/4020 | 131/8465 | 3.99e-05 | 2.16e-04 | 1.20e-04 | 85 |
hsa040688 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
hsa0406813 | Oral cavity | OSCC | FoxO signaling pathway | 85/3704 | 131/8465 | 7.50e-07 | 4.33e-06 | 2.21e-06 | 85 |
hsa040687 | Prostate | BPH | FoxO signaling pathway | 54/1718 | 131/8465 | 3.05e-08 | 3.59e-07 | 2.22e-07 | 54 |
hsa0406812 | Prostate | BPH | FoxO signaling pathway | 54/1718 | 131/8465 | 3.05e-08 | 3.59e-07 | 2.22e-07 | 54 |
hsa0406822 | Prostate | Tumor | FoxO signaling pathway | 54/1791 | 131/8465 | 1.32e-07 | 1.51e-06 | 9.36e-07 | 54 |
hsa0406832 | Prostate | Tumor | FoxO signaling pathway | 54/1791 | 131/8465 | 1.32e-07 | 1.51e-06 | 9.36e-07 | 54 |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO32 | SNV | Missense_Mutation | c.340N>G | p.Leu114Val | p.L114V | Q969P5 | protein_coding | deleterious(0.05) | benign(0.173) | TCGA-EW-A1J5-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | adriamycin | SD | |
FBXO32 | insertion | Frame_Shift_Ins | novel | c.687_688insGAGTTTTTAAATAGAGATGTTGTGTGTGTGTGTGTTTCAG | p.Leu230GlufsTer113 | p.L230Efs*113 | Q969P5 | protein_coding | TCGA-B6-A0IE-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | PD | ||
FBXO32 | SNV | Missense_Mutation | c.894C>G | p.Phe298Leu | p.F298L | Q969P5 | protein_coding | tolerated(0.06) | benign(0.125) | TCGA-WL-A834-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | paclitaxel | SD | |
FBXO32 | SNV | Missense_Mutation | rs370398489 | c.1024N>A | p.Val342Ile | p.V342I | Q969P5 | protein_coding | tolerated(0.41) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBXO32 | SNV | Missense_Mutation | c.364G>A | p.Val122Met | p.V122M | Q969P5 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-AA-3966-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXO32 | SNV | Missense_Mutation | novel | c.595N>T | p.Arg199Trp | p.R199W | Q969P5 | protein_coding | deleterious(0) | probably_damaging(0.997) | TCGA-AA-3984-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
FBXO32 | SNV | Missense_Mutation | c.610C>A | p.Leu204Ile | p.L204I | Q969P5 | protein_coding | tolerated(0.2) | benign(0.192) | TCGA-AA-A010-01 | Colorectum | colon adenocarcinoma | Female | <65 | I/II | Chemotherapy | folinic | CR | |
FBXO32 | SNV | Missense_Mutation | novel | c.707N>C | p.Ile236Thr | p.I236T | Q969P5 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FBXO32 | SNV | Missense_Mutation | novel | c.853N>A | p.Leu285Met | p.L285M | Q969P5 | protein_coding | tolerated(0.05) | possibly_damaging(0.73) | TCGA-AG-A002-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
FBXO32 | SNV | Missense_Mutation | novel | c.1061N>C | p.Lys354Thr | p.K354T | Q969P5 | protein_coding | deleterious(0.01) | possibly_damaging(0.501) | TCGA-F5-6814-01 | Colorectum | rectum adenocarcinoma | Male | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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