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Gene: FBXO3 |
Gene summary for FBXO3 |
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Gene information | Species | Human | Gene symbol | FBXO3 | Gene ID | 26273 |
Gene name | F-box protein 3 | |
Gene Alias | FBA | |
Cytomap | 11p13 | |
Gene Type | protein-coding | GO ID | GO:0006464 | UniProtAcc | Q49AF1 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26273 | FBXO3 | P22T-E | Human | Esophagus | ESCC | 9.18e-21 | 3.99e-01 | 0.1236 |
26273 | FBXO3 | P23T-E | Human | Esophagus | ESCC | 5.52e-11 | 3.60e-01 | 0.108 |
26273 | FBXO3 | P24T-E | Human | Esophagus | ESCC | 1.24e-12 | 1.57e-01 | 0.1287 |
26273 | FBXO3 | P26T-E | Human | Esophagus | ESCC | 1.27e-23 | 3.12e-01 | 0.1276 |
26273 | FBXO3 | P27T-E | Human | Esophagus | ESCC | 6.87e-15 | 2.64e-01 | 0.1055 |
26273 | FBXO3 | P28T-E | Human | Esophagus | ESCC | 5.76e-18 | 4.30e-01 | 0.1149 |
26273 | FBXO3 | P30T-E | Human | Esophagus | ESCC | 1.51e-14 | 6.60e-01 | 0.137 |
26273 | FBXO3 | P31T-E | Human | Esophagus | ESCC | 5.23e-15 | 2.16e-01 | 0.1251 |
26273 | FBXO3 | P32T-E | Human | Esophagus | ESCC | 2.50e-24 | 5.16e-01 | 0.1666 |
26273 | FBXO3 | P36T-E | Human | Esophagus | ESCC | 9.51e-16 | 4.20e-01 | 0.1187 |
26273 | FBXO3 | P37T-E | Human | Esophagus | ESCC | 3.94e-06 | 1.01e-01 | 0.1371 |
26273 | FBXO3 | P39T-E | Human | Esophagus | ESCC | 1.75e-13 | 1.01e-01 | 0.0894 |
26273 | FBXO3 | P40T-E | Human | Esophagus | ESCC | 1.26e-08 | 1.68e-01 | 0.109 |
26273 | FBXO3 | P42T-E | Human | Esophagus | ESCC | 6.76e-09 | 2.48e-01 | 0.1175 |
26273 | FBXO3 | P44T-E | Human | Esophagus | ESCC | 1.60e-05 | 1.17e-01 | 0.1096 |
26273 | FBXO3 | P47T-E | Human | Esophagus | ESCC | 1.50e-07 | 1.35e-01 | 0.1067 |
26273 | FBXO3 | P48T-E | Human | Esophagus | ESCC | 2.07e-15 | 1.77e-01 | 0.0959 |
26273 | FBXO3 | P49T-E | Human | Esophagus | ESCC | 5.04e-07 | 5.90e-01 | 0.1768 |
26273 | FBXO3 | P52T-E | Human | Esophagus | ESCC | 2.53e-15 | 3.54e-01 | 0.1555 |
26273 | FBXO3 | P54T-E | Human | Esophagus | ESCC | 4.24e-11 | 1.62e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
Page: 1 2 3 4 5 6 7 8 9 |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:00485459 | Breast | Precancer | response to steroid hormone | 53/1080 | 339/18723 | 3.07e-11 | 3.66e-09 | 53 |
GO:00319608 | Breast | Precancer | response to corticosteroid | 30/1080 | 167/18723 | 2.50e-08 | 1.65e-06 | 30 |
GO:00513848 | Breast | Precancer | response to glucocorticoid | 26/1080 | 148/18723 | 3.32e-07 | 1.57e-05 | 26 |
GO:00713838 | Breast | Precancer | cellular response to steroid hormone stimulus | 28/1080 | 204/18723 | 1.78e-05 | 4.26e-04 | 28 |
GO:00713846 | Breast | Precancer | cellular response to corticosteroid stimulus | 11/1080 | 61/18723 | 6.54e-04 | 8.01e-03 | 11 |
GO:00713856 | Breast | Precancer | cellular response to glucocorticoid stimulus | 10/1080 | 56/18723 | 1.23e-03 | 1.32e-02 | 10 |
GO:19016549 | Breast | Precancer | response to ketone | 22/1080 | 194/18723 | 1.89e-03 | 1.84e-02 | 22 |
GO:004854514 | Breast | IDC | response to steroid hormone | 70/1434 | 339/18723 | 1.34e-14 | 4.23e-12 | 70 |
GO:003196013 | Breast | IDC | response to corticosteroid | 37/1434 | 167/18723 | 3.10e-09 | 2.63e-07 | 37 |
GO:005138413 | Breast | IDC | response to glucocorticoid | 32/1434 | 148/18723 | 6.52e-08 | 4.07e-06 | 32 |
GO:007138314 | Breast | IDC | cellular response to steroid hormone stimulus | 35/1434 | 204/18723 | 5.29e-06 | 1.75e-04 | 35 |
GO:190165414 | Breast | IDC | response to ketone | 33/1434 | 194/18723 | 1.17e-05 | 3.13e-04 | 33 |
GO:007138413 | Breast | IDC | cellular response to corticosteroid stimulus | 12/1434 | 61/18723 | 2.01e-03 | 1.90e-02 | 12 |
GO:007138513 | Breast | IDC | cellular response to glucocorticoid stimulus | 11/1434 | 56/18723 | 3.08e-03 | 2.61e-02 | 11 |
GO:00030125 | Breast | IDC | muscle system process | 50/1434 | 452/18723 | 5.52e-03 | 4.05e-02 | 50 |
GO:004854524 | Breast | DCIS | response to steroid hormone | 67/1390 | 339/18723 | 1.02e-13 | 2.76e-11 | 67 |
GO:003196022 | Breast | DCIS | response to corticosteroid | 35/1390 | 167/18723 | 1.69e-08 | 1.18e-06 | 35 |
GO:005138422 | Breast | DCIS | response to glucocorticoid | 31/1390 | 148/18723 | 1.11e-07 | 5.93e-06 | 31 |
GO:007138324 | Breast | DCIS | cellular response to steroid hormone stimulus | 34/1390 | 204/18723 | 7.04e-06 | 1.95e-04 | 34 |
GO:190165423 | Breast | DCIS | response to ketone | 30/1390 | 194/18723 | 9.98e-05 | 1.82e-03 | 30 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FBXO3 | SNV | Missense_Mutation | c.85G>A | p.Asp29Asn | p.D29N | Q9UK99 | protein_coding | tolerated(0.29) | benign(0.137) | TCGA-A2-A0YG-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | cytoxan | SD | |
FBXO3 | SNV | Missense_Mutation | rs757358495 | c.251C>G | p.Ser84Cys | p.S84C | Q9UK99 | protein_coding | tolerated(0.08) | benign(0.339) | TCGA-AN-A0XW-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Unknown | Unknown | SD |
FBXO3 | SNV | Missense_Mutation | c.55N>A | p.Asp19Asn | p.D19N | Q9UK99 | protein_coding | deleterious(0.01) | probably_damaging(0.96) | TCGA-D8-A1JA-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | PD | |
FBXO3 | SNV | Missense_Mutation | c.1269G>T | p.Met423Ile | p.M423I | Q9UK99 | protein_coding | tolerated_low_confidence(0.45) | benign(0) | TCGA-C5-A1BM-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Unknown | Unknown | SD | |
FBXO3 | SNV | Missense_Mutation | novel | c.1062N>G | p.Ile354Met | p.I354M | Q9UK99 | protein_coding | deleterious(0.01) | possibly_damaging(0.837) | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD |
FBXO3 | insertion | Nonsense_Mutation | novel | c.1062_1063insTAA | p.Ile354_Ile355insTer | p.I354_I355ins* | Q9UK99 | protein_coding | TCGA-DS-A1OA-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | carboplatin | PD | ||
FBXO3 | SNV | Missense_Mutation | rs138194845 | c.1406N>A | p.Arg469His | p.R469H | Q9UK99 | protein_coding | deleterious_low_confidence(0) | benign(0.001) | TCGA-AA-3672-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
FBXO3 | SNV | Missense_Mutation | c.312G>T | p.Lys104Asn | p.K104N | Q9UK99 | protein_coding | deleterious(0.03) | benign(0.15) | TCGA-AA-3977-01 | Colorectum | colon adenocarcinoma | Male | >=65 | I/II | Unknown | Unknown | SD | |
FBXO3 | SNV | Missense_Mutation | novel | c.276N>G | p.His92Gln | p.H92Q | Q9UK99 | protein_coding | tolerated(0.29) | benign(0.129) | TCGA-CA-6717-01 | Colorectum | colon adenocarcinoma | Male | <65 | I/II | Chemotherapy | oxaliplatin | CR |
FBXO3 | SNV | Missense_Mutation | c.509G>A | p.Arg170His | p.R170H | Q9UK99 | protein_coding | deleterious(0.01) | possibly_damaging(0.869) | TCGA-AG-A025-01 | Colorectum | rectum adenocarcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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