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Gene: FARSA |
Gene summary for FARSA |
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Gene information | Species | Human | Gene symbol | FARSA | Gene ID | 2193 |
Gene name | phenylalanyl-tRNA synthetase subunit alpha | |
Gene Alias | CML33 | |
Cytomap | 19p13.13 | |
Gene Type | protein-coding | GO ID | GO:0006082 | UniProtAcc | Q6IBR2 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
2193 | FARSA | LZE4T | Human | Esophagus | ESCC | 4.96e-08 | 3.33e-01 | 0.0811 |
2193 | FARSA | LZE7T | Human | Esophagus | ESCC | 1.36e-11 | 9.05e-01 | 0.0667 |
2193 | FARSA | LZE20T | Human | Esophagus | ESCC | 5.29e-05 | 1.86e-01 | 0.0662 |
2193 | FARSA | LZE22D1 | Human | Esophagus | HGIN | 8.44e-05 | 1.40e-01 | 0.0595 |
2193 | FARSA | LZE24T | Human | Esophagus | ESCC | 3.35e-22 | 6.81e-01 | 0.0596 |
2193 | FARSA | LZE21T | Human | Esophagus | ESCC | 6.88e-06 | 5.76e-01 | 0.0655 |
2193 | FARSA | LZE6T | Human | Esophagus | ESCC | 3.03e-05 | 5.46e-01 | 0.0845 |
2193 | FARSA | P1T-E | Human | Esophagus | ESCC | 5.95e-14 | 4.98e-01 | 0.0875 |
2193 | FARSA | P2T-E | Human | Esophagus | ESCC | 2.53e-16 | 3.78e-01 | 0.1177 |
2193 | FARSA | P4T-E | Human | Esophagus | ESCC | 5.49e-32 | 7.67e-01 | 0.1323 |
2193 | FARSA | P5T-E | Human | Esophagus | ESCC | 5.11e-42 | 8.53e-01 | 0.1327 |
2193 | FARSA | P8T-E | Human | Esophagus | ESCC | 4.79e-38 | 7.00e-01 | 0.0889 |
2193 | FARSA | P9T-E | Human | Esophagus | ESCC | 2.52e-30 | 7.83e-01 | 0.1131 |
2193 | FARSA | P10T-E | Human | Esophagus | ESCC | 1.34e-32 | 6.33e-01 | 0.116 |
2193 | FARSA | P11T-E | Human | Esophagus | ESCC | 4.02e-11 | 7.40e-01 | 0.1426 |
2193 | FARSA | P12T-E | Human | Esophagus | ESCC | 4.20e-40 | 7.92e-01 | 0.1122 |
2193 | FARSA | P15T-E | Human | Esophagus | ESCC | 1.37e-25 | 5.13e-01 | 0.1149 |
2193 | FARSA | P16T-E | Human | Esophagus | ESCC | 5.44e-27 | 4.76e-01 | 0.1153 |
2193 | FARSA | P17T-E | Human | Esophagus | ESCC | 2.53e-19 | 1.08e+00 | 0.1278 |
2193 | FARSA | P19T-E | Human | Esophagus | ESCC | 2.26e-08 | 1.12e+00 | 0.1662 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
GO:0006418 | Colorectum | AD | tRNA aminoacylation for protein translation | 19/3918 | 41/18723 | 2.37e-04 | 3.03e-03 | 19 |
GO:0043039 | Colorectum | AD | tRNA aminoacylation | 19/3918 | 44/18723 | 7.13e-04 | 7.21e-03 | 19 |
GO:0043038 | Colorectum | AD | amino acid activation | 19/3918 | 45/18723 | 9.94e-04 | 9.28e-03 | 19 |
GO:0006520 | Colorectum | AD | cellular amino acid metabolic process | 81/3918 | 284/18723 | 1.37e-03 | 1.19e-02 | 81 |
GO:00064181 | Colorectum | SER | tRNA aminoacylation for protein translation | 17/2897 | 41/18723 | 5.75e-05 | 1.35e-03 | 17 |
GO:00430391 | Colorectum | SER | tRNA aminoacylation | 17/2897 | 44/18723 | 1.64e-04 | 3.12e-03 | 17 |
GO:00430381 | Colorectum | SER | amino acid activation | 17/2897 | 45/18723 | 2.25e-04 | 3.91e-03 | 17 |
GO:00065201 | Colorectum | SER | cellular amino acid metabolic process | 61/2897 | 284/18723 | 4.20e-03 | 3.41e-02 | 61 |
GO:00346606 | Esophagus | HGIN | ncRNA metabolic process | 104/2587 | 485/18723 | 2.26e-06 | 8.23e-05 | 104 |
GO:003466012 | Esophagus | ESCC | ncRNA metabolic process | 346/8552 | 485/18723 | 4.35e-31 | 2.51e-28 | 346 |
GO:00063992 | Esophagus | ESCC | tRNA metabolic process | 122/8552 | 179/18723 | 9.03e-10 | 2.19e-08 | 122 |
GO:00512623 | Esophagus | ESCC | protein tetramerization | 54/8552 | 87/18723 | 1.50e-03 | 7.06e-03 | 54 |
GO:00512592 | Esophagus | ESCC | protein complex oligomerization | 130/8552 | 238/18723 | 3.29e-03 | 1.36e-02 | 130 |
GO:00346603 | Liver | Cirrhotic | ncRNA metabolic process | 173/4634 | 485/18723 | 3.64e-08 | 1.21e-06 | 173 |
GO:000652011 | Liver | Cirrhotic | cellular amino acid metabolic process | 103/4634 | 284/18723 | 8.88e-06 | 1.30e-04 | 103 |
GO:00346601 | Liver | HCC | ncRNA metabolic process | 332/7958 | 485/18723 | 1.48e-31 | 7.80e-29 | 332 |
GO:00065202 | Liver | HCC | cellular amino acid metabolic process | 167/7958 | 284/18723 | 1.91e-08 | 4.56e-07 | 167 |
GO:0006399 | Liver | HCC | tRNA metabolic process | 108/7958 | 179/18723 | 1.07e-06 | 1.59e-05 | 108 |
GO:0051262 | Liver | HCC | protein tetramerization | 50/7958 | 87/18723 | 3.42e-03 | 1.55e-02 | 50 |
GO:0051290 | Liver | HCC | protein heterotetramerization | 12/7958 | 15/18723 | 3.56e-03 | 1.59e-02 | 12 |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FARSA | SNV | Missense_Mutation | c.205N>A | p.Glu69Lys | p.E69K | Q9Y285 | protein_coding | tolerated(0.57) | benign(0.006) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FARSA | SNV | Missense_Mutation | c.388N>C | p.Asp130His | p.D130H | Q9Y285 | protein_coding | deleterious(0.02) | benign(0.192) | TCGA-BH-A18P-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | PD | |
FARSA | SNV | Missense_Mutation | c.1113N>G | p.His371Gln | p.H371Q | Q9Y285 | protein_coding | deleterious(0.02) | possibly_damaging(0.905) | TCGA-C8-A134-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | 5-fluorouracil | CR | |
FARSA | insertion | Frame_Shift_Ins | rs777211508 | c.437_438insG | p.Gln147ThrfsTer3 | p.Q147Tfs*3 | Q9Y285 | protein_coding | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | ||
FARSA | insertion | Frame_Shift_Ins | novel | c.1404_1405insATAAAAAAATTAGGGCTGGGAA | p.Tyr469IlefsTer28 | p.Y469Ifs*28 | Q9Y285 | protein_coding | TCGA-AO-A0JJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Chemotherapy | cyclophospamide | SD | ||
FARSA | insertion | Nonsense_Mutation | novel | c.1049_1050insGGGAGGGCTAAGGCAACTACGTGGTCAGTGAAGGC | p.Tyr350Ter | p.Y350* | Q9Y285 | protein_coding | TCGA-BH-A0HF-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | ||
FARSA | deletion | Frame_Shift_Del | novel | c.174delN | p.Lys59SerfsTer101 | p.K59Sfs*101 | Q9Y285 | protein_coding | TCGA-D8-A27V-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Hormone Therapy | tamoxiphen | SD | ||
FARSA | SNV | Missense_Mutation | rs758130016 | c.1387N>T | p.Arg463Cys | p.R463C | Q9Y285 | protein_coding | deleterious(0) | probably_damaging(1) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FARSA | SNV | Missense_Mutation | rs145305261 | c.371N>A | p.Arg124Gln | p.R124Q | Q9Y285 | protein_coding | tolerated(0.44) | benign(0.01) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FARSA | SNV | Missense_Mutation | c.1417N>T | p.Asn473Tyr | p.N473Y | Q9Y285 | protein_coding | deleterious(0) | probably_damaging(0.998) | TCGA-AA-3492-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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