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Gene: FAM206A |
Gene summary for FAM206A |
 Gene summary. |
| Gene information | Species | Human | Gene symbol | FAM206A | Gene ID | 54942 |
| Gene name | actin binding transcription modulator | |
| Gene Alias | C9orf6 | |
| Cytomap | 9q31.3 | |
| Gene Type | protein-coding | GO ID | GO:0000902 | UniProtAcc | Q9NX38 |
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Malignant transformation analysis |
| Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
| Malignant transformation involving gene list. |
| Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
| 54942 | FAM206A | P28T-E | Human | Esophagus | ESCC | 6.02e-15 | 2.84e-01 | 0.1149 |
| 54942 | FAM206A | P30T-E | Human | Esophagus | ESCC | 1.85e-11 | 4.25e-01 | 0.137 |
| 54942 | FAM206A | P31T-E | Human | Esophagus | ESCC | 2.04e-17 | 2.90e-01 | 0.1251 |
| 54942 | FAM206A | P32T-E | Human | Esophagus | ESCC | 7.63e-25 | 4.92e-01 | 0.1666 |
| 54942 | FAM206A | P36T-E | Human | Esophagus | ESCC | 9.42e-10 | 3.84e-01 | 0.1187 |
| 54942 | FAM206A | P37T-E | Human | Esophagus | ESCC | 8.57e-12 | 3.19e-01 | 0.1371 |
| 54942 | FAM206A | P38T-E | Human | Esophagus | ESCC | 7.78e-10 | 5.10e-01 | 0.127 |
| 54942 | FAM206A | P39T-E | Human | Esophagus | ESCC | 1.76e-14 | 2.00e-01 | 0.0894 |
| 54942 | FAM206A | P40T-E | Human | Esophagus | ESCC | 1.17e-08 | 1.23e-01 | 0.109 |
| 54942 | FAM206A | P42T-E | Human | Esophagus | ESCC | 8.16e-09 | 3.63e-01 | 0.1175 |
| 54942 | FAM206A | P47T-E | Human | Esophagus | ESCC | 4.19e-14 | 2.18e-01 | 0.1067 |
| 54942 | FAM206A | P48T-E | Human | Esophagus | ESCC | 3.39e-10 | 1.56e-01 | 0.0959 |
| 54942 | FAM206A | P49T-E | Human | Esophagus | ESCC | 2.50e-09 | 5.43e-01 | 0.1768 |
| 54942 | FAM206A | P52T-E | Human | Esophagus | ESCC | 7.21e-21 | 4.50e-01 | 0.1555 |
| 54942 | FAM206A | P54T-E | Human | Esophagus | ESCC | 1.23e-12 | 1.50e-01 | 0.0975 |
| 54942 | FAM206A | P57T-E | Human | Esophagus | ESCC | 7.32e-04 | 8.75e-02 | 0.0926 |
| 54942 | FAM206A | P61T-E | Human | Esophagus | ESCC | 1.01e-06 | 2.06e-01 | 0.099 |
| 54942 | FAM206A | P62T-E | Human | Esophagus | ESCC | 2.48e-29 | 4.88e-01 | 0.1302 |
| 54942 | FAM206A | P65T-E | Human | Esophagus | ESCC | 3.62e-09 | 7.52e-02 | 0.0978 |
| 54942 | FAM206A | P74T-E | Human | Esophagus | ESCC | 2.26e-29 | 8.33e-01 | 0.1479 |
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| Transcriptomic changes along malignancy continuum. |
| Tissue | Expression Dynamics | Abbreviation |
| Esophagus |  | ESCC: Esophageal squamous cell carcinoma |
| HGIN: High-grade intraepithelial neoplasias | ||
| LGIN: Low-grade intraepithelial neoplasias | ||
| Liver |  | HCC: Hepatocellular carcinoma |
| NAFLD: Non-alcoholic fatty liver disease |
| ∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
| Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
| Figure of enriched GO biological processes. |
| Tissue | Disease Stage | Enriched GO biological Processes |
| Colorectum | AD |  |
| Colorectum | SER |  |
| Colorectum | MSS |  |
| Colorectum | MSI-H |  |
| Colorectum | FAP |  |
| ∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
| Page: 1 2 3 4 5 6 7 8 9 |
| Enriched GO biological processes. |
| GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
| Page: 1 |
| Enriched KEGG pathways. |
| Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
| Page: 1 |
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Cell-cell communication analysis |
| Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
| Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
| Page: 1 |
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Single-cell gene regulatory network inference analysis |
| Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
| TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
| ∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
| Page: 1 |
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Somatic mutation of malignant transformation related genes |
| Annotation of somatic variants for genes involved in malignant transformation |
| Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
| FAM206A | SNV | Missense_Mutation | c.357G>C | p.Leu119Phe | p.L119F | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.996) | TCGA-LP-A5U2-01 | Cervix | cervical & endocervical cancer | Female | <65 | III/IV | Unknown | Unknown | SD | |
| FAM206A | insertion | Frame_Shift_Ins | novel | c.221_222insTA | p.Ser75IlefsTer19 | p.S75Ifs*19 | Q9NX38 | protein_coding | TCGA-AG-A00C-01 | Colorectum | rectum adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fluorouracil | CR | ||
| FAM206A | SNV | Missense_Mutation | novel | c.353N>A | p.Arg118His | p.R118H | Q9NX38 | protein_coding | deleterious(0.02) | probably_damaging(0.938) | TCGA-AP-A1DK-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FAM206A | SNV | Missense_Mutation | novel | c.265N>A | p.Ala89Thr | p.A89T | Q9NX38 | protein_coding | deleterious(0) | possibly_damaging(0.773) | TCGA-AX-A06F-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | SD |
| FAM206A | SNV | Missense_Mutation | c.20C>T | p.Ala7Val | p.A7V | Q9NX38 | protein_coding | tolerated_low_confidence(0.31) | benign(0) | TCGA-D1-A103-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
| FAM206A | SNV | Missense_Mutation | novel | c.56A>G | p.Tyr19Cys | p.Y19C | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.972) | TCGA-D1-A175-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Chemotherapy | paclitaxel | SD |
| FAM206A | SNV | Missense_Mutation | novel | c.137N>A | p.Cys46Tyr | p.C46Y | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.968) | TCGA-FI-A2D0-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | I/II | Unknown | Unknown | SD |
| FAM206A | SNV | Missense_Mutation | novel | c.217N>G | p.Asn73Asp | p.N73D | Q9NX38 | protein_coding | tolerated(0.29) | benign(0.139) | TCGA-FI-A2D5-01 | Endometrium | uterine corpus endometrioid carcinoma | Female | <65 | III/IV | Chemotherapy | carboplatinum | PD |
| FAM206A | SNV | Missense_Mutation | novel | c.313N>C | p.Asp105His | p.D105H | Q9NX38 | protein_coding | deleterious(0) | probably_damaging(0.995) | TCGA-05-4398-01 | Lung | lung adenocarcinoma | Female | <65 | III/IV | Chemotherapy | carboplatin | CR |
| FAM206A | SNV | Missense_Mutation | novel | c.151N>A | p.Ala51Thr | p.A51T | Q9NX38 | protein_coding | deleterious(0.02) | benign(0.29) | TCGA-D7-A6EY-01 | Stomach | stomach adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | PD |
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Related drugs of malignant transformation related genes |
| Identification of chemicals and drugs interact with genes involved in malignant transfromation |
| (DGIdb 4.0) |
| Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
| Page: 1 |
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