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Gene: FAM195A |
Gene summary for FAM195A |
Gene summary. |
Gene information | Species | Human | Gene symbol | FAM195A | Gene ID | 84331 |
Gene name | MAPK regulated corepressor interacting protein 2 | |
Gene Alias | C16orf14 | |
Cytomap | 16p13.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BUT9 |
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Malignant transformation analysis |
Identification of the aberrant gene expression in precancerous and cancerous lesions by comparing the gene expression of stem-like cells in diseased tissues with normal stem cells |
Malignant transformation involving gene list. |
Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
84331 | FAM195A | P28T-E | Human | Esophagus | ESCC | 4.19e-82 | 1.29e+00 | 0.1149 |
84331 | FAM195A | P30T-E | Human | Esophagus | ESCC | 2.42e-52 | 1.43e+00 | 0.137 |
84331 | FAM195A | P31T-E | Human | Esophagus | ESCC | 9.74e-22 | 3.52e-01 | 0.1251 |
84331 | FAM195A | P32T-E | Human | Esophagus | ESCC | 2.49e-44 | 8.03e-01 | 0.1666 |
84331 | FAM195A | P36T-E | Human | Esophagus | ESCC | 1.26e-29 | 9.77e-01 | 0.1187 |
84331 | FAM195A | P37T-E | Human | Esophagus | ESCC | 5.97e-32 | 5.83e-01 | 0.1371 |
84331 | FAM195A | P38T-E | Human | Esophagus | ESCC | 7.90e-12 | 4.23e-01 | 0.127 |
84331 | FAM195A | P39T-E | Human | Esophagus | ESCC | 1.46e-28 | 4.87e-01 | 0.0894 |
84331 | FAM195A | P40T-E | Human | Esophagus | ESCC | 5.73e-13 | 3.27e-01 | 0.109 |
84331 | FAM195A | P42T-E | Human | Esophagus | ESCC | 2.19e-28 | 6.56e-01 | 0.1175 |
84331 | FAM195A | P44T-E | Human | Esophagus | ESCC | 5.44e-13 | 3.58e-01 | 0.1096 |
84331 | FAM195A | P47T-E | Human | Esophagus | ESCC | 3.02e-26 | 4.12e-01 | 0.1067 |
84331 | FAM195A | P48T-E | Human | Esophagus | ESCC | 2.28e-35 | 6.24e-01 | 0.0959 |
84331 | FAM195A | P49T-E | Human | Esophagus | ESCC | 6.13e-19 | 1.50e+00 | 0.1768 |
84331 | FAM195A | P52T-E | Human | Esophagus | ESCC | 9.14e-50 | 9.27e-01 | 0.1555 |
84331 | FAM195A | P54T-E | Human | Esophagus | ESCC | 2.77e-40 | 8.70e-01 | 0.0975 |
84331 | FAM195A | P56T-E | Human | Esophagus | ESCC | 1.26e-12 | 9.18e-01 | 0.1613 |
84331 | FAM195A | P57T-E | Human | Esophagus | ESCC | 4.19e-25 | 5.04e-01 | 0.0926 |
84331 | FAM195A | P61T-E | Human | Esophagus | ESCC | 5.13e-24 | 4.98e-01 | 0.099 |
84331 | FAM195A | P62T-E | Human | Esophagus | ESCC | 3.22e-70 | 1.15e+00 | 0.1302 |
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Transcriptomic changes along malignancy continuum. |
∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
Find out the enriched GO biological processes and KEGG pathways involved in transition from healthy to precancer to cancer |
Figure of enriched GO biological processes. |
Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | |
Colorectum | SER | |
Colorectum | MSS | |
Colorectum | MSI-H | |
Colorectum | FAP |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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Enriched GO biological processes. |
GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Enriched KEGG pathways. |
Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
Identification of potential cell-cell interactions between two cell types and their ligand-receptor pairs for different disease states |
Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
Find out the significant the regulons (TFs) and the target genes of each regulon across cell types for different disease states |
TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
Annotation of somatic variants for genes involved in malignant transformation |
Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
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Related drugs of malignant transformation related genes |
Identification of chemicals and drugs interact with genes involved in malignant transfromation |
(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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