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Gene: FAM189B |
Gene summary for FAM189B |
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Gene information | Species | Human | Gene symbol | FAM189B | Gene ID | 10712 |
Gene name | family with sequence similarity 189 member B | |
Gene Alias | C1orf2 | |
Cytomap | 1q22 | |
Gene Type | protein-coding | GO ID | GO:0008150 | UniProtAcc | P81408 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
10712 | FAM189B | P23T-E | Human | Esophagus | ESCC | 1.25e-17 | 5.56e-01 | 0.108 |
10712 | FAM189B | P24T-E | Human | Esophagus | ESCC | 3.46e-28 | 6.90e-01 | 0.1287 |
10712 | FAM189B | P26T-E | Human | Esophagus | ESCC | 6.26e-37 | 5.59e-01 | 0.1276 |
10712 | FAM189B | P27T-E | Human | Esophagus | ESCC | 9.34e-19 | 3.44e-01 | 0.1055 |
10712 | FAM189B | P28T-E | Human | Esophagus | ESCC | 1.11e-34 | 6.07e-01 | 0.1149 |
10712 | FAM189B | P30T-E | Human | Esophagus | ESCC | 1.27e-28 | 9.44e-01 | 0.137 |
10712 | FAM189B | P31T-E | Human | Esophagus | ESCC | 2.32e-20 | 3.21e-01 | 0.1251 |
10712 | FAM189B | P32T-E | Human | Esophagus | ESCC | 5.86e-21 | 3.53e-01 | 0.1666 |
10712 | FAM189B | P36T-E | Human | Esophagus | ESCC | 8.54e-21 | 6.50e-01 | 0.1187 |
10712 | FAM189B | P37T-E | Human | Esophagus | ESCC | 7.20e-15 | 3.24e-01 | 0.1371 |
10712 | FAM189B | P38T-E | Human | Esophagus | ESCC | 2.27e-09 | 3.66e-01 | 0.127 |
10712 | FAM189B | P39T-E | Human | Esophagus | ESCC | 1.22e-08 | 2.05e-01 | 0.0894 |
10712 | FAM189B | P40T-E | Human | Esophagus | ESCC | 2.19e-02 | 2.10e-01 | 0.109 |
10712 | FAM189B | P42T-E | Human | Esophagus | ESCC | 1.63e-17 | 5.56e-01 | 0.1175 |
10712 | FAM189B | P44T-E | Human | Esophagus | ESCC | 2.92e-04 | 1.92e-01 | 0.1096 |
10712 | FAM189B | P47T-E | Human | Esophagus | ESCC | 6.56e-14 | 2.90e-01 | 0.1067 |
10712 | FAM189B | P48T-E | Human | Esophagus | ESCC | 1.07e-11 | 2.66e-01 | 0.0959 |
10712 | FAM189B | P49T-E | Human | Esophagus | ESCC | 6.45e-18 | 1.44e+00 | 0.1768 |
10712 | FAM189B | P52T-E | Human | Esophagus | ESCC | 1.86e-22 | 4.98e-01 | 0.1555 |
10712 | FAM189B | P54T-E | Human | Esophagus | ESCC | 9.64e-15 | 3.79e-01 | 0.0975 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM189B | SNV | Missense_Mutation | c.153N>G | p.Phe51Leu | p.F51L | P81408 | protein_coding | tolerated(0.25) | benign(0.246) | TCGA-A1-A0SI-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM189B | SNV | Missense_Mutation | rs764162205 | c.214N>A | p.Ala72Thr | p.A72T | P81408 | protein_coding | deleterious(0.01) | benign(0.391) | TCGA-A8-A09Z-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | SD |
FAM189B | SNV | Missense_Mutation | novel | c.314G>T | p.Cys105Phe | p.C105F | P81408 | protein_coding | deleterious(0) | probably_damaging(0.987) | TCGA-S3-A6ZH-01 | Breast | breast invasive carcinoma | Female | <65 | III/IV | Chemotherapy | adriamycin | CR |
FAM189B | insertion | In_Frame_Ins | novel | c.365_366insATG | p.Leu122_Ala123insTrp | p.L122_A123insW | P81408 | protein_coding | TCGA-AC-A3QQ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAM189B | insertion | Nonsense_Mutation | novel | c.108_109insGTGGGGTCTTGCTGGGGGAGCTAAGGAAGGGGA | p.Thr36_Leu37insValGlySerCysTrpGlySerTerGlyArgGly | p.T36_L37insVGSCWGS*GRG | P81408 | protein_coding | TCGA-AN-A0FX-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | ||
FAM189B | SNV | Missense_Mutation | rs566720731 | c.964G>A | p.Val322Met | p.V322M | P81408 | protein_coding | deleterious(0) | probably_damaging(0.981) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR |
FAM189B | SNV | Missense_Mutation | c.1646N>A | p.Arg549Gln | p.R549Q | P81408 | protein_coding | tolerated(0.39) | benign(0.037) | TCGA-A6-5657-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Ancillary | leucovorin | SD | |
FAM189B | SNV | Missense_Mutation | c.223N>A | p.Ser75Thr | p.S75T | P81408 | protein_coding | tolerated(0.2) | benign(0.02) | TCGA-AD-6895-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Unknown | Unknown | SD | |
FAM189B | SNV | Missense_Mutation | rs774269913 | c.450N>T | p.Glu150Asp | p.E150D | P81408 | protein_coding | tolerated(0.25) | benign(0.003) | TCGA-AY-4070-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Chemotherapy | 5-fu | PD |
FAM189B | SNV | Missense_Mutation | c.97N>A | p.Ala33Thr | p.A33T | P81408 | protein_coding | tolerated(0.14) | possibly_damaging(0.624) | TCGA-G4-6320-01 | Colorectum | colon adenocarcinoma | Male | >=65 | III/IV | Chemotherapy | oxaliplatin | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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