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Gene: FAM127B |
Gene summary for FAM127B |
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Gene information | Species | Human | Gene symbol | FAM127B | Gene ID | 26071 |
Gene name | retrotransposon Gag like 8A | |
Gene Alias | CXX1b | |
Cytomap | Xq26.3 | |
Gene Type | protein-coding | GO ID | GO:0005575 | UniProtAcc | Q9BWD3 |
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Malignant transformation analysis |
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Entrez ID | Symbol | Replicates | Species | Organ | Tissue | Adj P-value | Log2FC | Malignancy |
26071 | FAM127B | P26T-E | Human | Esophagus | ESCC | 7.66e-107 | 2.05e+00 | 0.1276 |
26071 | FAM127B | P27T-E | Human | Esophagus | ESCC | 1.76e-47 | 9.63e-01 | 0.1055 |
26071 | FAM127B | P28T-E | Human | Esophagus | ESCC | 2.34e-44 | 9.42e-01 | 0.1149 |
26071 | FAM127B | P30T-E | Human | Esophagus | ESCC | 1.74e-35 | 1.68e+00 | 0.137 |
26071 | FAM127B | P31T-E | Human | Esophagus | ESCC | 2.18e-76 | 1.24e+00 | 0.1251 |
26071 | FAM127B | P32T-E | Human | Esophagus | ESCC | 2.06e-89 | 1.86e+00 | 0.1666 |
26071 | FAM127B | P36T-E | Human | Esophagus | ESCC | 3.27e-26 | 1.06e+00 | 0.1187 |
26071 | FAM127B | P37T-E | Human | Esophagus | ESCC | 1.26e-43 | 1.21e+00 | 0.1371 |
26071 | FAM127B | P38T-E | Human | Esophagus | ESCC | 9.18e-14 | 1.01e+00 | 0.127 |
26071 | FAM127B | P39T-E | Human | Esophagus | ESCC | 7.43e-46 | 8.40e-01 | 0.0894 |
26071 | FAM127B | P40T-E | Human | Esophagus | ESCC | 6.86e-32 | 1.25e+00 | 0.109 |
26071 | FAM127B | P42T-E | Human | Esophagus | ESCC | 2.62e-34 | 1.19e+00 | 0.1175 |
26071 | FAM127B | P44T-E | Human | Esophagus | ESCC | 3.93e-16 | 6.94e-01 | 0.1096 |
26071 | FAM127B | P47T-E | Human | Esophagus | ESCC | 3.42e-54 | 1.15e+00 | 0.1067 |
26071 | FAM127B | P48T-E | Human | Esophagus | ESCC | 8.87e-45 | 8.27e-01 | 0.0959 |
26071 | FAM127B | P49T-E | Human | Esophagus | ESCC | 1.06e-20 | 2.70e+00 | 0.1768 |
26071 | FAM127B | P52T-E | Human | Esophagus | ESCC | 1.98e-48 | 1.33e+00 | 0.1555 |
26071 | FAM127B | P54T-E | Human | Esophagus | ESCC | 2.83e-29 | 8.46e-01 | 0.0975 |
26071 | FAM127B | P56T-E | Human | Esophagus | ESCC | 1.18e-10 | 1.56e+00 | 0.1613 |
26071 | FAM127B | P57T-E | Human | Esophagus | ESCC | 1.49e-33 | 8.87e-01 | 0.0926 |
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∗log2FC in expression of this searched gene in stem-like cells from each diseased tissue sample relative to stem-like cells in normal samples in each tissue plotted against the malignancy continuum. Samples are colored based on if they are from different disease stage. |
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Malignant transformation related pathway analysis |
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Tissue | Disease Stage | Enriched GO biological Processes |
Colorectum | AD | ![]() |
Colorectum | SER | ![]() |
Colorectum | MSS | ![]() |
Colorectum | MSI-H | ![]() |
Colorectum | FAP | ![]() |
∗Top 15 enriched GO BP terms are showed in the bar plot of each disease state in each tissue. Each row represents a significant GO biological process which is colored according to the -log10(p.adjust). |
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GO ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | Count |
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Pathway ID | Tissue | Disease Stage | Description | Gene Ratio | Bg Ratio | pvalue | p.adjust | qvalue | Count |
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Cell-cell communication analysis |
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Ligand | Receptor | LRpair | Pathway | Tissue | Disease Stage |
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Single-cell gene regulatory network inference analysis |
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TF | Cell Type | Tissue | Disease Stage | Target Gene | RSS | Regulon Activity |
∗The dot plots of a searched regulon are shown for all cell subpopulations in each disease state of each tissue based on the regulon specific score inferred using pySCENIC and by calculating the average expression. |
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Somatic mutation of malignant transformation related genes |
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Hugo Symbol | Variant Class | Variant Classification | dbSNP RS | HGVSc | HGVSp | HGVSp Short | SWISSPROT | BIOTYPE | SIFT | PolyPhen | Tumor Sample Barcode | Tissue | Histology | Sex | Age | Stage | Therapy Types | Drugs | Outcome |
FAM127B | SNV | Missense_Mutation | c.24N>A | p.Met8Ile | p.M8I | Q9BWD3 | protein_coding | tolerated(1) | benign(0) | TCGA-AC-A23H-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM127B | SNV | Missense_Mutation | c.62N>A | p.Arg21His | p.R21H | Q9BWD3 | protein_coding | deleterious(0.02) | possibly_damaging(0.796) | TCGA-B6-A0IJ-01 | Breast | breast invasive carcinoma | Female | <65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | c.331N>A | p.Glu111Lys | p.E111K | Q9BWD3 | protein_coding | tolerated_low_confidence(0.11) | benign(0.003) | TCGA-GM-A2D9-01 | Breast | breast invasive carcinoma | Female | >=65 | I/II | Hormone Therapy | arimidex | SD | |
FAM127B | SNV | Missense_Mutation | c.65N>A | p.Arg22His | p.R22H | Q9BWD3 | protein_coding | tolerated(0.05) | probably_damaging(0.991) | TCGA-2W-A8YY-01 | Cervix | cervical & endocervical cancer | Female | <65 | I/II | Chemotherapy | cisplatin | CR | |
FAM127B | SNV | Missense_Mutation | novel | c.10C>T | p.Arg4Trp | p.R4W | Q9BWD3 | protein_coding | deleterious(0) | possibly_damaging(0.779) | TCGA-VS-A8EK-01 | Cervix | cervical & endocervical cancer | Female | >=65 | I/II | Chemotherapy | cisplatin | PD |
FAM127B | SNV | Missense_Mutation | novel | c.263N>A | p.Ser88Asn | p.S88N | Q9BWD3 | protein_coding | deleterious(0.03) | probably_damaging(0.999) | TCGA-5M-AAT6-01 | Colorectum | colon adenocarcinoma | Female | <65 | III/IV | Unknown | Unknown | PD |
FAM127B | SNV | Missense_Mutation | c.211N>T | p.Arg71Cys | p.R71C | Q9BWD3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-A6-5665-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | PD | |
FAM127B | SNV | Missense_Mutation | c.211C>T | p.Arg71Cys | p.R71C | Q9BWD3 | protein_coding | deleterious(0) | probably_damaging(0.991) | TCGA-AA-3815-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | c.18G>C | p.Gln6His | p.Q6H | Q9BWD3 | protein_coding | tolerated(0.06) | benign(0.264) | TCGA-AA-3866-01 | Colorectum | colon adenocarcinoma | Female | >=65 | I/II | Unknown | Unknown | SD | |
FAM127B | SNV | Missense_Mutation | c.56N>T | p.Ala19Val | p.A19V | Q9BWD3 | protein_coding | tolerated(0.29) | benign(0.074) | TCGA-AA-3949-01 | Colorectum | colon adenocarcinoma | Female | >=65 | III/IV | Unknown | Unknown | SD |
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Related drugs of malignant transformation related genes |
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(DGIdb 4.0) |
Entrez ID | Symbol | Category | Interaction Types | Drug Claim Name | Drug Name | PMIDs |
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